Viability of randomized skin flaps—an experimental study in rats

Abstract

The use of each substance alone or combined increased flap viability compared with control groups. On the seventh day, PTX exhibited lower viability than HLD, whereas on the 14th day there was no difference between treated groups. PTX alone enhanced the L of blood vessels, whereas PTX-HLD did not. However, PTX-HLD was more effective in decreasing the dermis cellularity and macrophage V than HLD alone.

Benefits of pentoxifylline for skin flap tissue repair in rats

“…The proangiogenic effects of pentoxifylline on ischemic tissues have been observed in several studies. The administration of intradermal hyaluronidase combined with intraperitoneal pentoxifylline for 14 days showed a decrease in the cellularity of macrophages on the dermis, while the administration of pentoxifylline alone stimulated angiogenesis 17 . The biochemical and histopathological findings suggest that low doses of pentoxifylline can effectively improve ischemic damage in the experimental model of skin flaps 30 .…”

“…Other 8,9,11,13,14,[16][17][18][19][28][29][30][31][32] have demonstrated that parenteral administration of pentoxifylline with different schemes and doses ranging from 1 to 50 mg/kg, was able to improve tissue vitality.…”

“…Despite different methodologies, the literature has published researches 1,[11][12][13][14][15][16][17][18]33 showing that pentoxifylline contributed to healing. Many of the cellular events associated with the migration of keratinocytes are induced and regulated by individual growth factors or a combination of growth factors that locally stimulate molecules found close to the injury 1,17,33 .…”

“…Images were obtained out of every 20 fields/slides in areas with a higher concentration of collagen fibers. Pixel densities for the regions occupied by the collagen fibers were selected on the real image for subsequent creation of a binary image for densitometric quantification 11,16,17,27 .…”

“…It plays a role in morphological immunomodulation, decreases the inflammatory action, and has a fibrinogenic action, with decreased collagen synthesis. This potent antioxidant acts by inhibiting the superoxide anion synthesis and may reduce the toxic reperfusion metabolites, with a reduction in those responsible for tissue damage and consequent increase in flap survival 8,9,[11][12][13][14][15][16][17][18] .…”