Veterinary Oral and Maxillofacial Pathology

Murphy, Brian G; Bell, Cynthia M; Soukup, Jason W.

doi:10.1002/9781119221296

Cited by 40 publications

(132 citation statements)

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“…Key diagnostic features include location (gingival mucosa), low magnification architecture (broad anastomosing trabeculae), and the presence of cardinal odontogenic features. Peripheral CAA merges with the gingival epithelium, as it is thought to be derived from the remnant dental lamina, which is an invagination of the surface epithelium in early odontogenesis 1 . Histologically, this neoplasm displayed the cardinal features of odontogenic epithelium: peripheral palisading of cells, antibasilar nuclei, and basilar clearing (basilar clearing was rare and not shown in the histologic image).…”

Section: Discussionmentioning

confidence: 96%

“…The primary gross and histologic differential for CAA is canine oral squamous cell carcinoma (COSCC) 1 . There is substantial morphologic overlap in these two diagnoses.…”

Section: Discussionmentioning

confidence: 99%

“…In COSCC, neoplastic cells tend to have more features of atypia (eg, mitoses and anaplasia), are frequently infiltrated by inflammatory cells, and are invasive. Invasiveness is the most important diagnostic feature of COSCC, as atypia and inflammation could be absent in some CAA cases 1 . Keratinization varies widely in COSCC, is usually absent in the papillary variant of COSCC, and can be present in CAA.…”

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? Gingival mass in a Golden Retriever

Fiddes¹,

Murphy

Hauck³

et al. 2020

Veterinary Clinical Pathol

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Section: Discussionmentioning

confidence: 96%

“…The primary gross and histologic differential for CAA is canine oral squamous cell carcinoma (COSCC) 1 . There is substantial morphologic overlap in these two diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? Gingival mass in a Golden Retriever

Fiddes¹,

Murphy

Hauck³

et al. 2020

Veterinary Clinical Pathol

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“…In addition, the grade of the histological differentiation does not appear to strongly affect predicting the presence or extension of bone involvement (43). Likewise, in cats, oral SCCs can reportedly present as severely aggressive tumours despite being well-differentiated histologically (1). A feline study showed that the lingual location was associated with younger cats, suggesting a possible different pathogenesis, influenced by the epithelial susceptibility to develop SCC (44).…”

Section: Degree Of Keratinizationmentioning

confidence: 99%

“…Oral and sinonasal squamous cell carcinomas (SCCs) are keratinocyte tumours derived from the stratified squamous epithelium of the mucosa (1). SCCs are thought to be the most common nasal and paranasal tumour in horses (2,3) and the most common malignant oral tumour in cats, accounting for 60-70% of all feline malignant oral tumours (4,5).…”

Section: Introductionmentioning

confidence: 99%

Computed Tomographic and Histopathological Characteristics of 13 Equine and 10 Feline Oral and Sinonasal Squamous Cell Carcinomas

2020

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Squamous cell carcinoma (SCC) is the most common equine sinonasal and feline oral tumour. This study aimed to describe the computed tomographic and histopathological characteristics of equine and feline SCC. Thirteen horses and 10 cats that had been histopathologically diagnosed with oral or sinonasal SCC and had undergone computed tomography (CT) of the head were retrospectively included in the study. CT characteristics of the mass and involved structures were noted. Histological examinations were evaluated according to a human malignancy grading system for oral SCC, which considered four grades of increasing aggressiveness. In horses, the masses were at the levels of the paranasal sinuses (n = 8), mandible (n = 3), tongue (n = 1), and nasal cavity (n = 1). In cats, the masses were at the levels of the maxilla (n = 4), mandible (n = 3), tongue (n = 1), and buccal region (n = 1) and were diffusely distributed (facial and cranial bones; n = 1). Masses in the equine paranasal sinuses showed only mild, solid/laminar, periosteal reactions with variable cortical destruction. However, maxillary lesions in cats showed severe cortical destruction and irregular, amorphous/pumice stone-like, periosteal reactions. CT revealed different SCC phenotypes that were unrelated to the histological grade. For morphologic parameters of the tumour cell population, a variability for the degree of keratinization and number of mitotic cells was noted in horses and cats. Concerning the tumour-host relationship a marked, extensive and deep invasion into the bone in the majority of horses and cats was seen. Most cases in both the horses and cats were categorized as histological grade III (n = 8); four horses and one cat were categorized as grade IV, and one horse and one cat were categorized as grade II. In this study, we examined the diagnostic images and corresponding applied human histopathological grading of SCC to further elucidate the correlations between pathology and oral and sinonasal SCC imaging in horses and cats.

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Surgical management and histopathology of wen overgrowth and neoplasia in four oranda goldfish (Carassius auratus)

Mones

Schreeg

Sommer

et al. 2021

Vet Record Case Reports

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The wen is a cap of gelatinous soft tissue that extends over the head and face of many varieties of fancy goldfish (Carassius auratus). Here, we describe the surgical management and histopathology of four fish with proliferative wen lesions. All fish were anesthetized for debulking or biopsy of the affected wen. One fish was diagnosed with wen hyperplasia, one fish was diagnosed with wen hyperplasia with a concurrent spindle cell neoplasm, and two fish were diagnosed with epithelial neoplasms of the wen, including a carcinoma arising within a papilloma and an epidermal papilloma with spindle cell and hyalinized matrix proliferation. This is the first published report of neoplasia in the wen of fancy goldfish. Regular evaluation of the wen during routine physical examinations may allow for biopsy of wen lesions, leading to early diagnosis and treatment interventions.

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Veterinary Oral and Maxillofacial Pathology

Cited by 40 publications

References 0 publications

What is your diagnosis? Gingival mass in a Golden Retriever

What is your diagnosis? Gingival mass in a Golden Retriever

Computed Tomographic and Histopathological Characteristics of 13 Equine and 10 Feline Oral and Sinonasal Squamous Cell Carcinomas

Surgical management and histopathology of wen overgrowth and neoplasia in four oranda goldfish (Carassius auratus)

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