Veterinary Dysmorphology

Moura, Enio; Cludia, T.

doi:10.5772/32344

Cited by 4 publications

(7 citation statements)

References 41 publications

(51 reference statements)

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“…), or personal impressions, it has been suggested that maternal exposure to various substances such as hydroxyurea, griseofulvin, anabasine, metronidazole, primidone, sulphonamides, and corticosteroids can cause oral clefts in dogs [30]. Indeed, as the morphogenic processes are highly conserved [35], the same causes of oral dysmorphogenesis known in man can also be found in other species of mammals, including dogs, and vice versa ( Table 2).…”

Section: Etiologymentioning

confidence: 99%

“…Due to its etiology, a cleft lip or palate may be the result of an originally abnormal development process or negative interference in a normal development process, corresponding to the concepts of malformation and disruption, respectively, used in dysmorphology [35].…”

Section: Pathogenesismentioning

confidence: 99%

“…The heterogeneous etiology, in cases of malformation and disruption, assumes varied mechanisms in the development of CL/P. While some mechanisms impair the morphogenesis of various structures in addition to the palate, resulting in syndromic clefts, others act only in the palatogenesis, resulting in nonsyndromic clefts [29,35].…”

Section: Pathogenesismentioning

confidence: 99%

“…As the majority of oral clefts in dogs appear to be multifactorial or recessive, it should be noted that owners of normal dogs who have had affected offspring are not always willing to follow this recommendation, especially when the dogs have characteristics of their breed that are highly valued. Therefore, if the owners/breeders decide to cross them again, and are sure that the cleft lip or palate is genetic in nature, the risk of recurrence should be seriously taken into consideration [35].…”

Section: Genetic Counselingmentioning

confidence: 99%

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Cleft Lip and Palate in the Dog: Medical and Genetic Aspects

Moura¹,

Pimpão²

2017

Designing Strategies for Cleft Lip and Palate Care

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The same types of cleft lip and/or cleft palate (CL/P) that affects humans also naturally affect dogs. Therefore, the dog has become an important spontaneous animal model for the study of human oral clefts. In order to provide an overview of CL/P in dogs to people with an interest in this area, we present in this chapter the main medical aspects, ranging from the etiology to the prevention, and also the main genetic aspects, including inheritance mechanisms and highlighting the homology between the two species, and the most recent molecular findings.

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Section: Etiologymentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Section: Genetic Counselingmentioning

confidence: 99%

See 2 more Smart Citations

Cleft Lip and Palate in the Dog: Medical and Genetic Aspects

Moura¹,

Pimpão²

2017

Designing Strategies for Cleft Lip and Palate Care

Self Cite

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“…(c) Gastroschisis in a newborn Siberian husky. From Veterinary Dysmorphology (Moura & Pimpão, ) under CC BY 3.0 license…”

Section: Postulated Developmental Biology Of Gastroschisismentioning

confidence: 99%

An evolutionary and developmental biology approach to gastroschisis

Opitz

Feldkamp

Botto

2019

Birth Defects Research

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Recent advances have now made it possible to speak of gastroschisis narrowly in morphogenetic terms invoking the Rittler-Beaudoin (R-B) model. This proceeds from the appreciation of gastroschisis as a congenital intestinal herniation (without cover or liver) within the primordial umbilical ring, mostly to the right side of a normally formed umbilical cord. Presently, it is unresolved whether this visceral prolapse represents failure of ring closure before return of the physiological hernia into the abdomen or rupture of the delicate amniotic/peritoneal membrane at the ring's edge to the right of the cord. Animal observations and experiments will be required to address this question effectively. If gastroschisis is, in fact, a primary malformation with the primordial umbilical ring as the developmental field involved, then homology implies potential gastroschisis in all amniotes with corresponding nourishment from yolk sac (aka omphalomesenteric) vessels going into the embryo and excretory products out via the ancient umbilical connection. It also implies homology of corresponding morphogenetic signal transduction cascades. We review the history of gastroschisis, its presumed pathogenesis, and the developmental biology of the amniotic umbilical ring from this perspective. Therefore, based on the animal and human evidence to date, we propose that gastroschisis is a primary midline malformation that involves the umbilical canal from amniotic to peritoneal space and its primordial umbilical ring, either through nonclosure or rupture of the membrane covering the area, mostly to the right, between the cord and the edge of the ring.

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Prenatal diagnosis of foetal hydrocephalus and suspected X-linked recessive inheritance of cleft lip in a Chihuahua

Sananmuang

Mankong

Jeeratanyasakul

et al. 2020

The Journal of Veterinary Medical Science

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A 3.5-year-old, 2.9 kg, multiparous Chihuahua presented with abdominal distension; pregnancy was diagnosed. On Day 7 before parturition, prenatal sonograms showed anechoic bilateral dilated cerebral lateral ventricles, suggesting fluid-filled regions (ventriculomegaly) in one foetus. A Caesarean section was performed and the male newborn had an abnormally enlarged dome-shaped head and a cleft lip, and died 6 days after birth. According to the family pedigree, the X-linked recessive inheritance of an orofacial cleft from the unaffected mother was suggested. This report clearly demonstrates that canine foetal ventriculomegaly (hydrocephalus) can be diagnosed in utero. For dog breeds predisposed to congenital ventriculomegaly, early detection is important for the prediction of perinatal survival and adequate supportive care can be applied at delivery.

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Veterinary Dysmorphology

Cited by 4 publications

References 41 publications

Cleft Lip and Palate in the Dog: Medical and Genetic Aspects

Cleft Lip and Palate in the Dog: Medical and Genetic Aspects

An evolutionary and developmental biology approach to gastroschisis

Prenatal diagnosis of foetal hydrocephalus and suspected X-linked recessive inheritance of cleft lip in a Chihuahua

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