Veterinary Drug Residues in Foods

Croubels, Siska; Daeseleire, Els

doi:10.1016/b978-0-08-100674-0.00006-0

Cited by 24 publications

(20 citation statements)

References 205 publications

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“…More than 150 antibiotics are used in the production of livestock products used for human consumption and 90% of them are natural products of bacteria, fungi and semi-synthetic substances obtained as a result of natural products modification or even synthesis (4). The most widely used antimicrobial agents used in treatment of productive animals are β-lactams, tetracyclines, aminoglycosides, lincosa-mides, macrolides, and sulfonamides (5,6). Close to AN-VISA (7).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial susceptability of E. coli strains isolated from raw milk

Ушкалов

Данчук

Ushkalov

et al. 2021

OH&RM

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ntroduction. The processing of most raw milk products can lead to contamination with unwanted microflora due to poor sanitation and hygienic conditions. The inadequate antibiotic use over the past decades has led to the emergence and wide spread of bacterial populations, particularly of Escherichia coli, which developed resistance to antibacterial drugs.Material and methods. Raw milk samples were obtained from clinically healthy cows on farms from Kiev and Poltava regions to identify E . coli, Staphylococcus spp., Enterococcus spp. isolates. Antimicrobial susceptibility testing was performed using the EUCAST disk diffusion method and MU on “Determination of microbial susceptibility to antibacterial drugs”. Results. The examined milk samples revealed the presence of E . coli, Staphylococcus spp. and Enterococcus spp. isolates, which proves poor sanitary and hygienic conditions of milk production process. Escherichia coli isolates were found susceptible to Ampicillin/sulbactam, Cefoxitin (100%), Meropenem, Tobramycin (100%), Netilin, Tigecycline, Nitroxoline (100%), Gatifloxacin, and Nitrofurantoin (100%). The studied E. coli isolates were found resistant to Ampicillin (100%), Imipenem, Tetracycline, and Doxycycline (100%). 41.7% of isolates of Staphylococcus epidermidis, Staphylococcus aureus were found resistant to Oxacillin, of which 90% were resistant to Benzylpenicillin and 20% to Rifampicin. Conclusions.The circulation of antibiotic-resistant Enterobacteriaceae strains among farm animals is a major problem requiring a strategy development aimed to prevent the emergence and spread of antibiotic resistance worldwide.

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Section: Introductionmentioning

confidence: 99%

Antibacterial susceptability of E. coli strains isolated from raw milk

Ушкалов

Данчук

Ushkalov

et al. 2021

OH&RM

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“…On the basis of the scientific assessment of the safety of those substances and to protect public health, the presence of veterinary drug residues in foodstuffs of animal origin is regulated by the European Union (Commission Regulation EC No 2377/90) [ 38 ] with imposed maximum residue limits (MRLs). Based on the lowest acceptable daily intake, together with metabolism and residue depletion studies, the MRLs of the residues are determined for each tissue, expressed in micrograms per kilogram on a fresh-weight basis [ 39 ]. In most of the cases, the MRLs are related to the parent compounds, but they could also be based on single metabolites or a mixture of compounds.…”

Section: Analysis Of Veterinary Drug Residuesmentioning

confidence: 99%

Suitability of High-Resolution Mass Spectrometry for Routine Analysis of Small Molecules in Food, Feed and Water for Safety and Authenticity Purposes: A Review

Gavage

Delahaut

Gillard

2021

Foods

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During the last decade, food, feed and environmental analysis using high-resolution mass spectrometry became increasingly popular. Recent accessibility and technological improvements of this system make it a potential tool for routine laboratory work. However, this kind of instrument is still often considered a research tool. The wide range of potential contaminants and residues that must be monitored, including pesticides, veterinary drugs and natural toxins, is steadily increasing. Thanks to full-scan analysis and the theoretically unlimited number of compounds that can be screened in a single analysis, high-resolution mass spectrometry is particularly well-suited for food, feed and water analysis. This review aims, through a series of relevant selected studies and developed methods dedicated to the different classes of contaminants and residues, to demonstrate that high-resolution mass spectrometry can reach detection levels in compliance with current legislation and is a versatile and appropriate tool for routine testing.

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“…Antibiotics rank third with 16% of sales [5]. The pharmacotoxicology and the patterns of tissue residues of different drugs used in livestock animals, which are beyond the scope of the current work, have been widely described in the literature [6][7][8]. To integrally assess the topic, this comprehensive review article addresses different aspects of drug residues in edible tissues produced as food for human consumption and provides relevant information contributing to rational pharmacotherapy in food-producing animals.…”

Section: Introductionmentioning

confidence: 99%

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

Cantón

Lanusse

Moreno

2021

Animals

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Drugs are used in veterinary medicine to prevent or treat animal diseases. When rationally administered to livestock following Good Veterinary Practices (GVP), they greatly contribute to improving the production of food of animal origin. Since humans can be exposed chronically to veterinary drugs through the diet, residues in food are evaluated for effects following chronic exposures. Parameters such as an acceptable daily intake (ADI), the no-observed-adverse-effect level (NOAEL), maximum residue limits (MRLs), and the withdrawal periods (WPs) are determined for each drug used in livestock. Drug residues in food exceeding the MRLs usually appear when failing the GVP application. Different factors related either to the treated animal or to the type of drug administration, and even the type of cooking can affect the level of residues in edible tissues. Residues above the MRLs can have a diverse negative impact, mainly on the consumer’s health, and favor antimicrobial resistance (AMR). Drug residue monitoring programmes are crucial to ensure that prohibited or authorized substances do not exceed MRLs. This comprehensive review article addresses different aspects of drug residues in edible tissues produced as food for human consumption and provides relevant information contributing to rational pharmacotherapy in food-producing animals.

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Veterinary Drug Residues in Foods

Cited by 24 publications

References 205 publications

Antibacterial susceptability of E. coli strains isolated from raw milk

Antibacterial susceptability of E. coli strains isolated from raw milk

Suitability of High-Resolution Mass Spectrometry for Routine Analysis of Small Molecules in Food, Feed and Water for Safety and Authenticity Purposes: A Review

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

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