Vestibular Function Change in a Vasopressin-Induced Hydrops Model

Kim, Minbum; Kim, Kyu-Sung

doi:10.1097/mao.0000000000001574

Cited by 14 publications

(10 citation statements)

References 20 publications

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“…12 In addition, various animal models of endolymphatic hydrops to date have not been able to reproduce clinical features representative of Ménière's disease, although the latest approach with vasopressin in guinea pigs with surgically induced endolymphatic hydrops has produced more promising results. 13,14 It has even been suggested that endolymphatic hydrops be regarded as an epiphenomenon rather than the underlying aetiology of Ménière's disease. 10 Nevertheless, a meta-analysis of temporal bone studies by Foster and Breeze puts forward a convincing theory that, whilst endolymphatic hydrops probably causes Ménière's disease, it alone is insufficient to cause clinical symptoms and there must be one or more additional cofactors that cause asymptomatic hydrops to become symptomatic Ménière's disease.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre

et al. 2020

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BackgroundRecent developments in magnetic resonance imaging have enabled demonstration of endolymphatic hydrops, and the clinical application of these imaging studies in Ménière's disease is being explored.ObjectiveTo evaluate our centre's experience to date of hydrops magnetic resonance imaging in patients with episodic vertigo.MethodsMagnetic resonance imaging was performed using a high-resolution three-dimensional fluid-attenuated inversion recovery sequence on a 3 Tesla scanner at 4 hours following double-dose gadolinium administration.ResultsThe study included 31 patients, 28 of whom had a clinical diagnosis of Ménière's disease. In unilateral Ménière's disease, magnetic resonance imaging was able to lateralise endolymphatic hydrops to the clinically symptomatic ear in all cases. Mild hydrops was often seen in clinically asymptomatic ears.ConclusionThere is a good correlation between the clinical symptoms and lateralisation of hydropic changes on magnetic resonance imaging. Further refinements of imaging techniques and grading system will likely improve the diagnostic accuracy and clinical utilisation of hydrops magnetic resonance imaging.

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Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre

et al. 2020

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“…Indeed, Egami et al, made clear the role of vasopressin in the endolymph homeostasis and its close contact with inner ear function; administration of desmopressin (a VP type 2 receptor agonist) can exacerbate EH because of acute V2 (vasopressin type 2 receptor)-mediated effects, and, when combined with ES dysfunction, can cause temporary vestibular abnormalities that are similar to the vertiginous attacks in patients with MD [6]. Recently, Kim et al also confirmed that this application of the vasopressin type 2 receptor agonist in experimentally-induced EH produced asymmetric vestibular dysfunction in bidirectional sinusoidal harmonic acceleration test, similar to bidirectional nystagmus in MD [165].…”

Section: Vertiginous or Dizzy Attackmentioning

confidence: 93%

A possible mechanism of the formation of endolymphatic hydrops and its associated inner ear disorders

Takeda

Takeda²,

Kakigi

2020

Auris Nasus Larynx

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“…Vasopressin type 2 receptors are also found in other sites besides the kidney such as the inner ear and vascular endothelium (35). The use of desmopressin may be associated with a worsening of endolymphatic hydrops in the inner ear through the presence of VR2 in the endolymphatic sac (36)(37)(38)(39). These receptors are also associated with increased levels of clotting factor VIII, von Willebrand factor, and tissue plasminogen activator in endothelial cells (35).…”

Section: Hormonesmentioning

confidence: 99%

Otorhinolaryngological adverse effects of urological drugs

2021

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Purpose: To describe the otorhinolaryngological adverse effects of the main drugs used in urological practice. Materials and Methods: A review of the scientifi c literature was performed using a combination of specifi c descriptors (side effect, adverse effect, scopolamine, sildenafi l, tadalafi l, vardenafi l, oxybutynin, tolterodine, spironolactone, furosemide, hydrochlorothiazide, doxazosin, alfuzosin, terazosin, prazosin, tamsulosin, desmopressin) contained in publications until April 2020. Manuscripts written in English, Portuguese, and Spanish were manually selected from the title and abstract. The main drugs used in Urology were divided into fi ve groups to describe their possible adverse effects: alpha-blockers, anticholinergics, diuretics, hormones, and phosphodiesterase inhibitors. Results: The main drugs used in Urology may cause several otorhinolaryngological adverse effects. Dizziness was most common, but dry mouth, rhinitis, nasal congestion, epistaxis, hearing loss, tinnitus, and rhinorrhea were also reported and varies among drug classes. Conclusions: Most of the drugs used in urological practice have otorhinolaryngological adverse effects. Dizziness was most common, but dry mouth, rhinitis, nasal congestion, epistaxis, hearing loss, tinnitus, and rhinorrhea were also reported. Therefore, doctors must be aware of these adverse effects to improve adherence to the treatment and to minimize damage to the health of patients.

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Vestibular Function Change in a Vasopressin-Induced Hydrops Model

Abstract: VP can transiently induce an acute exacerbation of hydrops and asymmetric vestibular dysfunction in guinea pigs. This model could help in studying new treatments for acute hydrops and in explaining the mechanism of bidirectional nystagmus in MD.

Cited by 14 publications

References 20 publications

Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre

Magnetic resonance imaging of Ménière's disease: early clinical experience in a UK centre

A possible mechanism of the formation of endolymphatic hydrops and its associated inner ear disorders

Otorhinolaryngological adverse effects of urological drugs

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