Vessel repair after balloon angioplasty: Morphological appearance and prostacyclin synthesising capacity

Mattsson, Erney; Brunkwall, Jan; Fält, K; Bergqvist, David

doi:10.1016/s0950-821x(05)80832-1

Cited by 10 publications

(3 citation statements)

References 21 publications

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“…One explanation for the contrasting observations is that the luminal cells were SMCs, which had achieved some characteristics similar to endothelial cells. 25 A hybrid cell of this kind has so far not been described in humans. We are currently looking at graft explants to see if such a cell exists in man.…”

Section: Discussionmentioning

confidence: 99%

Healing of PTFE Grafts in a Pig Model Recruit Neointimal Cells from Different Sources and Do Not Endothelialize

Mellander¹,

Fogelstrand²,

Enocson

et al. 2005

European Journal of Vascular and Endovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Healing of PTFE Grafts in a Pig Model Recruit Neointimal Cells from Different Sources and Do Not Endothelialize

Mellander¹,

Fogelstrand²,

Enocson

et al. 2005

European Journal of Vascular and Endovascular Surgery

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“…They reported that endothelium dependent responses of the injured arteries remained impaired for 10 weeks after injury, although re-endothelialization was complete by 2 weeks. Balloon injury was associated with an early reduction in the release of prostacyclin and thromboxane, although this was not sustained (Mattsson et al 1992(Mattsson et al , 1993b. The early vasospasm often associated with angioplasty did not appear to be due to endothelin (Mattsson et al 1993a).…”

Section: Re-endothelializationmentioning

confidence: 99%

The mechanisms of coronary restenosis: insights from experimental models

Ferns

Avades

2000

Int J Experimental Path

119

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Since its introduction into clinical practice, more than 20 years ago, percutaneous transluminal coronary angioplasty (PTCA) has proven to be an effective, minimally invasive alternative to coronary artery bypass grafting (CABG). During this time there have been great improvements in the design of balloon catheters, operative procedures and adjuvant drug therapy, and this has resulted in low rates of primary failure and short-term complications. However, the potential benefits of angioplasty are diminished by the high rate of recurrent disease. Up to 40% of patients undergoing angioplasty develop clinically significant restenosis within a year of the procedure. Although the deployment of endovascular stents at the time of angioplasty improves the short-term outcome, 'in-stent' stenosis remains an enduring problem. In order to gain an insight into the mechanisms of restenosis, several experimental models of angioplasty have been developed. These have been used together with the tools provided by recent advances in molecular biology and catheter design to investigate restenosis in detail. It is now possible to deliver highly specific molecular antagonists, such as antisense gene sequences, to the site of injury. The knowledge provided by these studies may ultimately lead to novel forms of intervention. The present review is a synopsis of our current understanding of the pathological mechanisms of restenosis.

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“…Luminal SMCs can adopt an endothelial-like cell function [28]. One potential explanation is that the luminal SMCs in this study lost the α-actin epitope during such a functional transformation.…”

Section: Discussionmentioning

confidence: 90%

External Collar Inhibits Balloon-Induced Intimal Hyperplasia in Rabbits

Fogelstrand

Risberg²,

Mattsson³

2002

J Vasc Res

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Intimal hyperplasia is a common complication following vascular interventions. To understand the underlying pathophysiology, the focus has mainly been on the intima and media. The adventitia has been less investigated, although adventitial hyperplasia is seen together with intimal hyperplasia. If the adventitial response is an important part of the process, the adventitia might be a target to inhibit intimal hyperplasia. In the present study we investigated whether an external collar attenuating the adventitial thickness could inhibit a balloon-induced intimal hyperplasia. The common carotid artery was injured in rabbits (n = 6) with a 3-french balloon catheter. The mid portion of the injured artery was encircled with a silicone collar (diameter = 2.0 mm). After 14 days the balloon-induced neointima was reduced by 54 ± 6.3% underneath the collar. The adventitial and medial thickenings were also attenuated (36 ± 8.7 and 44 ± 4.3%, respectively). This study demonstrates that intimal hyperplasia following balloon injury can be inhibited with an external collar. This supports the idea of the adventitia as a potential target to inhibit intimal hyperplasia.

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Vessel repair after balloon angioplasty: Morphological appearance and prostacyclin synthesising capacity

Cited by 10 publications

References 21 publications

Healing of PTFE Grafts in a Pig Model Recruit Neointimal Cells from Different Sources and Do Not Endothelialize

Healing of PTFE Grafts in a Pig Model Recruit Neointimal Cells from Different Sources and Do Not Endothelialize

The mechanisms of coronary restenosis: insights from experimental models

External Collar Inhibits Balloon-Induced Intimal Hyperplasia in Rabbits

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