Vesicular Nanocarriers: A Potential Platform for Dermal and Transdermal Drug Delivery

Kassem, Ahmed Alaa; El-Alim, Sameh Hosam Abd

doi:10.1007/978-3-030-44921-6_5

Cited by 10 publications

(7 citation statements)

References 321 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The droplet size of the nanoemulsion is typically in the range 20 to 300 nm for an optimized penetration with topical application. The results of the optimized formula showed a globule size of 245 nm which was in agreement with previously published data which indicated that, the globular size for any transdermal and topically applied vesicular drug delivery system is preferred to be less than 300 nm in order to penetrate easily through skin layers [ 42 , 43 ].…”

Section: Resultssupporting

confidence: 89%

See 1 more Smart Citation

Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment

2020

View full text Add to dashboard Cite

Acne vulgaris is a common skin disease that affects everybody at least once in their lives. The treatment is challenging because the stratum corneum contains rigid corneocytes surrounded by intercellular lamellae that are difficult to bypass. In the present study, we intended to formulate an effective nanoemulsion that could deliver isotretinoin (ITT) with enhanced solubility, permeability, and bioavailability across the skin. ITT can have a serious hepatotoxic effect if given too frequently or erratically. Therefore, to overcome the aforesaid limitation, quercetin (QRS), a hepatoprotective agent, was incorporated into the formulation. Initially, the ITT solubility was determined in various surfactants and cosurfactants to select the essential ingredients to be used in the formulation and to optimize a nanoemulsion that could enhance the solubility and permeability of ITT and its antimicrobial activity against Staphyloccocus aureus, which is the main microorganism responsible for acne vulgaris. The mixture design was applied to study the interactions and optimize the independent variables that could match the prerequisites of selected dependent responses. A formulation containing 0.25 g of rosehip oil, 0.45 g of surfactant (Lauroglycol-90), and 0.3 g of cosurfactant (propylene glycol) was chosen as an optimized desirable formulation. The optimized batch was loaded with QRS and evaluated for in vitro and ex vivo permeation. The in vivo hepatotoxicity was assessed through topical administration. Permeability studies confirmed the enhanced permeation percentage of ITT (52.11 ± 2.85%) and QRS (25.44 ± 3.18%) of the optimized formulation, with an enhanced steady-state flux (Jss). The in vivo studies conducted on experimental animals demonstrated superior hepatoprotective activity of the prepared optimized formulation compared with other formulations of drugs and commercially marketed products. We anticipate that this optimized ITT formulation, followed up with good clinical evaluations, can be a breakthrough in the safe treatment of acne vulgaris.

show abstract

Section: Resultssupporting

confidence: 89%

“…The above results showed a higher significant effect of the rosehip oil concentration compared with the other variables. This was due to the antimicrobial properties of the rosehip oil [ 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment

2020

View full text Add to dashboard Cite

show abstract

“…For instance, a clove oil-based NE was developed to combine the anti-inflammatory and antifungal properties of the main oil component, eugenol, with those of the drug cargo, naftifine, used to tackle skin fungal infections [ 39 ]. Lately, other types of liposome-inspired vesicles ( Figure 5 ), such as ethosomes, transfersomes, niosomes, among other, have been advanced [ 1 , 3 , 40 , 41 ]. Lipid-based/inspired nanosystems stem from ancient knowledge on the value of fatty acids and derived hydrolyzable lipids, especially phospholipids, to enhance percutaneous absorption of a variety of substances for both health- and beauty-care.…”

Section: Overview Of Current Methods For Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

“…Lipid-based/inspired nanosystems stem from ancient knowledge on the value of fatty acids and derived hydrolyzable lipids, especially phospholipids, to enhance percutaneous absorption of a variety of substances for both health- and beauty-care. Phospholipid-based emulsions, as well as micellar and liposomal formulations for skin care are all around us, hence it comes as no surprise that lipid-based/inspired nanocarriers have a prominent role in current approaches for DTD of [bio]pharmaceuticals [ 1 , 3 , 40 , 41 , 42 , 43 ]. Still, nanosystems that do not [exclusively] derive from natural lipids have been thoroughly explored for percutaneous permeation of bioactive molecules; organic nanoformulations comprising either natural or synthetic polymers and/or surfactants other than natural lipids can be found in recent literature, covering distinct types of dendrimers, nanoparticles (NPs), nanoemulsions (NEs), micelles, and hydrogels, for diverse purposes.…”

Section: Overview Of Current Methods For Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Gomes

Aguiar

Ferraz

et al. 2021

IJMS

View full text Add to dashboard Cite

Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.

show abstract

“…Propylene glycol, water, ethanol, transcutol P, caprylic acid, and isopropyl alcohol are some of the solvents that can increase drug permeation through a number of different mechanisms, including the disruption of intercellular lipid structures, fluidization of stratum corneum (SC) lipids, modification of cellular proteins, and extraction of intercellular lipids. Polar solvents, such as dimethyl sulfoxide (DMSO) and dimethyl form amide, were shown to enhance the stratum corneum's diffusely (DMFA) (10,11). Minoxidil is the most common drug used to treat hair loss, which is available as a generic medication over-the-counter for treating androgenic alopecia and, a form of hair loss in people with a molecular weight of 209.253 g/mol.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Various Vehicles on the In Vitro Skin Permeability of Minoxidil

Salimi¹,

Moghimipour²,

Kashani³

et al. 2022

J Kermanshah Univ Med Sci

View full text Add to dashboard Cite

Background: This study aimed to examine the uptake of the model therapeutic agent, minoxidil, through the skin, under the influence of different vehicles. Therefore, the effect of different penetration enhancers such as Propylene glycol, water, ethanol, transcutol P, caprylic acid, and Isopropyl alcohol were evaluated on skin permeability of minoxidil through rat skin. Methods: The skin permeability of minoxidil on rat skin was analyzed through a Franz cell by evaluating the parameters, including Jss, ERflux, ERD, and ERp. The enhancement mechanisms were studied by comparing FT-IR peak intensities for asymmetric and symmetric C-H stretching, ester C=O stretching, and Amide peaks. The mean transition temperature (Tm) and their enthalpies (ΔH) were investigated by the DSC technique. Results: Caprylic acid had the highest diffusion coefficient enhancement ratio (ERD), followed by propylene glycol and water. All solvents have ERD flux enhancement ratio. Solubility in the stratum corneum limited partitioning. All carriers enhanced drug permeability from rat skin, according to FTIR and DSC. Conclusions: Caprylic acid is an effective topical vehicle for minoxidil due to greater partitioning and diffusion through rat skin.

show abstract

Vesicular Nanocarriers: A Potential Platform for Dermal and Transdermal Drug Delivery

Cited by 10 publications

References 321 publications

Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment

Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

The Effect of Various Vehicles on the In Vitro Skin Permeability of Minoxidil

Contact Info

Product

Resources

About