Vesicular Lesions in Secondary Syphilis

DEXTER, HELEN L. T.

doi:10.1001/archderm.1952.01530240107018

Cited by 2 publications

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“…These have been thought to occur commonly in debilitated patients but this view has been contradicted by many reports. [4][5][6][7] We considered drug rash as the first possibility since morphology was consistent with the diagnosis and the patient reported sudden onset of lesions after drug intake. Therefore, a short course of oral steroids was prescribed.…”

Section: Discussionmentioning

confidence: 99%

“…2 However, no case of vesicular syphilid was reported in the study. Few cases of vesicular 3–6 or pustular 2,7 syphilids are reported in the literature. These have been thought to occur commonly in debilitated patients but this view has been contradicted by many reports.…”

Section: Discussionmentioning

confidence: 99%

“…These have been thought to occur commonly in debilitated patients but this view has been contradicted by many reports. 4–7…”

Section: Discussionmentioning

confidence: 99%

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Vesicular syphilid in a seropositive patient

2013

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Syphilis is a sexually transmitted infection with various stages of evolution and a myriad of presentations. To avoid a delay in diagnosis, it is important to recognize secondary syphilis presenting with vesicular lesions. A patient presented with maculopapular rash of recent onset with several vesicles and related the eruption to paracetamol taken one day before. The differential diagnoses considered were drug eruption, pityriasis lichenoides et varioliformis acuta, pityriasis rosea and secondary syphilis. HIV, VDRL (1:256) and TPHA tests were positive and histopathology revealed lymphohistiocytic infiltrate and plasma cells. Thus, a diagnosis of secondary syphilis coexisting with HIV was confirmed. The patient was administered benzathine penicillin and anti-retroviral therapy was started. He responded very well to treatment. We report this case because of the rarity of vesicular eruption in secondary syphilis.

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Section: Discussionmentioning

confidence: 99%