Vesicles Functionalized with a CO-Releasing Molecule for Light-Induced CO Delivery

Abstract

In this paper, a new type of methodology to deliver carbon monoxide (CO) for biological applications has been introduced. An amphiphilic manganese carbonyl complex (1.Mn) incorporated into the 1,2-distearoyl-sn-glycero-3-phosphocholine lipid vesicles has been reported first time for the photoinduced release of CO. The liposomes (Ves-1.Mn) gradually released CO under light at 365 nm over a period of 50 min with a half-time of 26.5 min. The CO-releasing ability of vesicles appended with 1.Mn complexes has been confirmed by myoglobin assay and infrared study. The vesicles appended with 1.Mn have the advantages of biocompatibility, water solubility, and steady and slow CO release. This approach could be a rational approach for applying various water-insoluble photoinduced CO donors in aqueous media by using vesicles as a nanocarrier for CO release.

Metal-free carbon monoxide-releasing micelles undergo tandem photochemical reactions for cutaneous wound healing

“…[7][8][9][10] These CORMs can be roughly categorized into two sorts, namely metal carbonyls and metal-free CORMs. Although metal carbonyls hold great promise in both laboratory and clinical investigations, 9,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] the development of metal-free CORMs has recently been receiveing increasing attention. 27 In this context, boranocarbonates, 28 CO-releasing prodrugs operated in a "click and release" manner, [29][30][31] and photoresponsive organic CORMs such as 3-hydroxyavone (3-HF) derivatives, [32][33][34][35][36][37] xanthene-9-carboxylic acid, 38 BODIPY derivatives, 39 and aromatic a-diketone derivatives 40 have been developed.…”

Vitamin E-facilitated carbon monoxide pro-drug nanomedicine for efficient light-responsive combination cancer therapy

“…CORM was also prepared according to the procedure in Sakla et al 39 . Thin film hydration method was employed to formulate LUCTF lipid nanoparticles, as detailed in Table 1.…”

Multifunctional Carbon Monoxide Prodrug-Loaded Nanoplatforms for Effective Photoacoustic Imaging-Guided Photothermal/Gas Synergistic Therapy

“…14,15 One strategy is to construct biocompatible CO-generating systems that integrate with nanocarriers for stimuli-responsive CO generation. 16,17 For this purpose, many nanomaterials have been designed through conjugating CO-releasing molecules (CORM) on different kinds of nanocarriers, which can be triggered by enzymes, chemical ligands, or light for successful CO release. 18−20 Despite the great potential of controllable COreleasing systems, some limitations are still being considered.…”

“…To date, a majority of efforts have been made to realize the on-demand release of CO to tumor sites for effective cancer therapy with minimal side effects. , One strategy is to construct biocompatible CO-generating systems that integrate with nanocarriers for stimuli-responsive CO generation. , For this purpose, many nanomaterials have been designed through conjugating CO-releasing molecules (CORM) on different kinds of nanocarriers, which can be triggered by enzymes, chemical ligands, or light for successful CO release. − Despite the great potential of controllable CO-releasing systems, some limitations are still being considered. For example, the limited penetrability and the phototoxicity of UV–vis light restrict their practical utility, and the addition of chemical reagents also have some adverse effects on biological systems.…”