Very Low Seroprevalence of HTLV-I/II in Cuba: Antibodies in Blood Donors and in Hematological and Nonhematological Patients

Ramírez, Patricia; Jiménez, Rivero; Santovenia, M.; Leyva, L.; Matutes, E.; Carovsky, Daniel; Yamaguchi, Kazunari; Fukuyoshi, Yoko; Nishimura, Yoko; Kiyokawa, Tetsuyuki; Takatsuki, Kiyoshi

doi:10.1159/000461371

Cited by 5 publications

(4 citation statements)

References 1 publication

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“…Such prevalence was slightly lower than those observed in other Caribbean islands where HTLV-1 antibodies are usually recognised in up to 15% of adults (Blattner et al, 1982;Yoshida, 1999). Low prevalence for, or even lack of infection with HTLV-I was found in other studies conducted on blood donors in Cuba, some of which did not apparently discriminate between HTLV-1 and HTLV-II (Hernandez Ramirez et al, 1991;Silva Cabrera et al, 1997). However, the report of sporadic cases of HTLV-1-associated with tropical spastic paraparesis suggests that both the spread of HTLV-1 and major route of transmission in Cuba need to be better investigated (Estrada et al, 1995).…”

Section: Hhv-8 and Htlv-1 In Cubamentioning

confidence: 80%

Infection with human herpesvirus type 8 and human T-cell leukaemia virus type 1 among individuals participating in a case–control study in Havana City, Cuba

et al. 2002

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Infection with human herpesvirus type 8 and with human T-cell leukaemia virus type-1 shows strong geographic variations. We conducted this study to assess prevalence and risk factors for human herpesvirus type 8 infection in Havana City, Cuba. Information and residual serum samples already collected for a hospital based case -control study were used. A total of 379 individuals (267 males and 112 females; median age=63 years) were evaluated. Antibodies to the lytic antigen of human herpesvirus type 8 were detected by using an immunofluorescence assay, while human T-cell leukaemia virus type-1 serology was performed by means of an ELISA test (alpha Biotech). Overall, 64 subjects (16.9%, 95% confidence interval: 13.1 -20.0) were positive for human herpesvirus type 8 antibodies. Human herpesvirus type 8 seroprevalence significantly increased with age (odds ratio=1.9 for 565 vs 555 years), and was twice as frequent in blacks than in whites. No association emerged with gender, socio-economic indicators, family size, history of sexually transmitted disease, sexual behaviour. Overall, 16 persons had anti-human T-cell leukaemia virus type-1 antibodies (4.2%, 95% confidence interval: 2.2 -6.4). No relationship emerged between human T-cell leukaemia virus type-1 and human herpesvirus type 8 serostatus. The study findings indicate that human herpesvirus type 8 infection is relatively common in Havana City, Cuba, suggesting that Cuba may represent an intermediate endemical area. Sexual transmission does not seem to play a major role in the spread human herpesvirus type 8 infection.

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Section: Hhv-8 and Htlv-1 In Cubamentioning

confidence: 80%

Infection with human herpesvirus type 8 and human T-cell leukaemia virus type 1 among individuals participating in a case–control study in Havana City, Cuba

et al. 2002

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“…There are several studies from Cuba and Dominican Republic that tried to confirm that high endemicity and morbidity. Surprisingly, three sero-epidemiological studies carried on Cuban blood donors found 0.25%, 0.27% and 0.99% HTLV positivity, even though they included a significant number of black Cubans [214][215][216]. Dominican Republic and Puerto Rico report 2.5% and 0.2% positivity in blood donors, respectively [217][218][219].…”

Section: Htlv Prevalence and Morbidity In Latin Americamentioning

confidence: 99%

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

Chabay

Lens

Hassan

et al. 2020

Cancers

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The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations.

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“…Thisfigure of 3,7% amongst multiply transfused patransfusion is one of the main vehicles of transmission of HTLV-1. Efforts are on the way to institute mass screening of blood do-nOm for HTLV-1 at our Transfusion Centre in spite of its prohibitive costs; since reports in the recent literature confirm transfusion-acquired HTLV-1 spastic paresis [6, (1) and haemophilia (2). ed blood.…”

Section: Htlv-1 In Multiply Transfusedmentioning

confidence: 99%

HTLV‐1 in Multiply Transfused Patients in Trinidad and Tobago, West Indies

Daisley

Charles²,

Landeau

et al. 1993

Vox Sanguinis

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Very Low Seroprevalence of HTLV-I/II in Cuba: Antibodies in Blood Donors and in Hematological and Nonhematological Patients

Cited by 5 publications

References 1 publication

Infection with human herpesvirus type 8 and human T-cell leukaemia virus type 1 among individuals participating in a case–control study in Havana City, Cuba

Infection with human herpesvirus type 8 and human T-cell leukaemia virus type 1 among individuals participating in a case–control study in Havana City, Cuba

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED

HTLV‐1 in Multiply Transfused Patients in Trinidad and Tobago, West Indies

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