Very early onset inflammatory bowel disease in a South Asian country where inflammatory bowel disease is emerging: a distinct clinical phenotype from later onset disease

Banerjee, Rupa; Pal, Partha; Nabi, Zaheer; Shava, Upender; Girish, Gandikota; Reddy, D. Nageshwar

doi:10.5217/ir.2020.00107

Cited by 11 publications

(10 citation statements)

References 47 publications

(55 reference statements)

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“…The prevalence of pediatric-onset IBD is increasing [25,26]. Pediatric cases have been reported to account for up to 25% of all IBD cases in Western countries.…”

Section: Age At Onsetmentioning

confidence: 99%

Inflammatory bowel disease in Korea: epidemiology and pathophysiology

Lee

Eun

2022

Korean J Intern Med

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Inflammatory bowel disease (IBD) refers to a group of disorders, including Crohn's disease and ulcerative colitis, that exhibit similar but distinct manifestations. These diseases are characterized by refractory and chronic inflammation of the bowel. IBD is usually accompanied by severe symptoms. When a patient presents with suspected IBD, physicians encounter various challenges in terms of diagnosis and treatment. In addition, given such characteristics, the associated medical expenses gradually increase. Although IBD was formerly known as a disease of Western countries, the incidence and prevalence are increasing in Korea. Korean investigators have accumulated a great deal of knowledge about the regional characteristics and epidemiology of the disease, especially via well-organized, joint cohort studies. Against this background, this article describes the epidemiology of IBD in Korea compared to that in the West. In addition, an overview of the pathophysiology of the disease is provided, focusing on the latest results.

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“…The prevalence of pediatric-onset IBD is increasing [25,26]. Pediatric cases have been reported to account for up to 25% of all IBD cases in Western countries.…”

Section: Age At Onsetmentioning

confidence: 99%

Inflammatory bowel disease in Korea: epidemiology and pathophysiology

Lee

Eun

2022

Korean J Intern Med

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“…10,11 VEO-IBD, often defined as IBD diagnosed before 6 years of age, is associated with a different clinical phenotype, treatment response, and outcomes relative to children diagnosed at older ages. [12][13][14] Previous systematic reviews on the incidence and prevalence of pediatric-onset IBD have not explicitly described the epidemiology of VEO-IBD.…”

mentioning

confidence: 99%

Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review

Kuenzig¹,

Fung²,

Marderfeld³

et al. 2022

Gastroenterology

272

154

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“…More recent Indian studies, which included perianal disease developed both at diagnosis and subsequent follow-up, however, have found even lower rates than other Asian cohorts. Banerjee et al [ 40 ] reported 7.4% perianal involvement amongst CD patients and a multicentre paediatric study in India reported 10.9% of CD patients with perianal disease(fistula or abscess). These findings suggest South Asian CD patients in their native countries do not experience disproportionately high rates of perianal disease.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network

Huang¹,

Wong²,

Chew³

et al. 2022

WJG

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BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease (PIBD). AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform. METHODS Clinical, endoscopic and radiologic data at diagnosis from the registry were extracted between 1 st January 1995 to 31 st December 2019. Disease phenotypic characteristics were classified as per the Paris classification system. RESULTS There was a distinct rise in new PIBD cases: Nearly half (48.6%) of the cohort was diagnosed in the most recent 5 years (2015-2019). The ratio of Crohn’s disease (CD):Ulcerative colitis (UC):IBD-Unclassified was 55.9%:38.3%:5.8%. The mean age was 9.07 years with a high proportion of very early onset IBD (VEO-IBD) (29.3%) and EO-IBD (52.7%). An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort (6.8%-9.0% Indians in census). Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease ( P = 0.003). CD patients presented with significantly more constitutional symptoms (fever, anorexia, malaise/fatigue and muscle-wasting) than UC and higher inflammatory indices (higher C-reactive protein and lower albumin levels). CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity. South Asian CD patients were more likely to have symptomatic perianal disease.

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Very early onset inflammatory bowel disease in a South Asian country where inflammatory bowel disease is emerging: a distinct clinical phenotype from later onset disease

Cited by 11 publications

References 47 publications

Inflammatory bowel disease in Korea: epidemiology and pathophysiology

Inflammatory bowel disease in Korea: epidemiology and pathophysiology

Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review

Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network

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