Very advanced maternal age: Pregnancy after age 45

Dildy, Gary A.; Jackson, G. Marc; Fowers, G K; Oshiro, Bryan T.; Varner, Michael W.; Clark, Steven L.

doi:10.1053/ob.1996.v175.a74402

Cited by 130 publications

(130 citation statements)

References 18 publications

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“…La exhaustiva vigilancia del estado materno-fetal durante el parto hace que no haya diferencias en el estado de los recién nacidos entre ambos grupos, resultados coincidentes con los de otros autores 27 . Sin embargo, el porcentaje de neonatos que requirieron ingreso en la Unidad de Cuidados Intensivos Neonatales (UCINN) fue superior en el grupo de estudio.…”

Section: Discussionunclassified

La edad materna como factor de riesgo obstétrico. Resultados perinatales en gestantes de edad avanzada

Pérez

Tejedor

Cepeda

et al. 2011

Progresos de Obstetricia y Ginecología

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Section: Discussionunclassified

La edad materna como factor de riesgo obstétrico. Resultados perinatales en gestantes de edad avanzada

Pérez

Tejedor

Cepeda

et al. 2011

Progresos de Obstetricia y Ginecología

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“…It is one of the most consistent epidemiological findings that the rate of the obstetric complications is greatly increased in women of advanced maternal age [163][164][165][166][167][168][169][170][171][172][173][174][175][176]. Both antepartum and intrapartum complications are increased quite significantly with increasing maternal age.…”

Section: Impact Of Maternal Age On Obstetric Complicationsmentioning

confidence: 99%

“…Increased risk of caesarean section is almost universally confirmed to be associated with increased maternal age [171][172][173][174][175][176]. Both patients' and care providers' anxiety undoubtedly contributes to the higher rate of caesarean section in older women.…”

Section: Impact Of Maternal Age On Obstetric Complicationsmentioning

confidence: 99%

Reproductive ageing in women

Djahanbakhch

Ezzati

Zosmer

2007

The Journal of Pathology

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The traditional view in respect to female reproduction is that the number of oocytes at birth is fixed and continuously declines towards the point when no more oocytes are available after menopause. In this review we briefly discuss the embryonic development of female germ cells and ovarian follicles. The ontogeny of the hypothalamic-pituitary-gonadal axis is then discussed, with a focus on pubertal transition and normal ovulatory menstrual cycles during female adult life. Biochemical markers of menopausal transition are briefly examined. We also examine the effects of age on female fertility, the contribution of chromosomal abnormalities of the oocyte to the observed decline in female fertility with age and the possible biological basis for the occurrence of such abnormalities. Finally, we consider the effects of maternal age on obstetric complications and perinatal outcome. New data that have the potential to revolutionize our understanding of mammalian oogenesis and follicular formation, and of the female reproductive ageing process, are also briefly considered.

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“…The mechanism for this is unlikely to be low birth weight as this has not been consistently linked to advanced maternal age. [14][15][16] There may be a stronger association between advanced age and low birth weight in studies from less developed countries, where the mothers having children at older ages are doing so for different reasons than women in the UK at present. In the relatively healthy, wealthy population of older mothers in this cohort, the influence of age on outcome may be less important.…”

Section: Biological Plausibilitymentioning

confidence: 99%

“…Advanced maternal age is associated with various adverse perinatal outcomes. Older mothers are at a higher risk of gestational diabetes and hypertension, [14][15][16] instrumental deliveries, caesarean section and genetic anomalies. 14,16 Further, in some studies higher maternal age is related to lower birth weight, prematurity and intrauterine growth retardation.…”

Section: Introductionmentioning

confidence: 99%

Maternal age in pregnancy and offspring blood pressure in childhood in the Avon Longitudinal Study of Parents and Children (ALSPAC)

et al. 2005

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Associations between maternal age in pregnancy and offspring blood pressure (BP) at age 7 1 2 were investigated in 7623 singletons from the Avon Longitudinal Study of Parents and Children (ALSPAC). In models adjusted for age and sex there was an inverse relationship between maternal age and BP in children: b ¼ À0.06 mmHg per year of maternal age (95% CI À0.10 to À0.01, P ¼ 0.02) for systolic BP and b ¼ À0.04 (95% CI À0.07 to À0.01, P ¼ 0.02) for diastolic BP.However, this association disappeared after adjustment for confounding factors: b ¼ À0.02 mmHg per year of maternal age (95% CI À0.07 to 0.04, P ¼ 0.5) for systolic BP and b ¼ À0.03 (95% CI À0.07 to 0.01, P ¼ 0.2) for diastolic BP. We conclude that there is no evidence of a relationship between maternal age in pregnancy and childhood BP in this contemporary birth cohort.

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Very advanced maternal age: Pregnancy after age 45

Cited by 130 publications

References 18 publications

La edad materna como factor de riesgo obstétrico. Resultados perinatales en gestantes de edad avanzada

La edad materna como factor de riesgo obstétrico. Resultados perinatales en gestantes de edad avanzada

Reproductive ageing in women

Maternal age in pregnancy and offspring blood pressure in childhood in the Avon Longitudinal Study of Parents and Children (ALSPAC)

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