Maternal age in pregnancy and offspring blood pressure in childhood in the Avon Longitudinal Study of Parents and Children (ALSPAC)

Roberts, Russel J.; Leary, Sam D; Smith, George Davey; Ness, Andy R

doi:10.1038/sj.jhh.1001915

Cited by 13 publications

(22 citation statements)

References 25 publications

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“…That the effect of infant diet on child BP was barely attenuated by adjustment for both birth weight and current child body size may have indicated that the observed association between diet and BP was unlikely to be explained solely in terms of either fetal growth restriction or catch-up growth. Nor does the effect appear to be dependent on prenatal factors, such as maternal characteristics or sociodemographic factors, which is an observation consistent with other studies (14,41,42). Because the final regression model (4) showed that current body weight influenced systolic BP and attenuated the effect of early diet on BP, our results also highlighted that the tracking of diet might be one mechanisms through which current body weight influences BP.…”

Section: Discussionsupporting

confidence: 85%

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Diet spanning infancy and toddlerhood is associated with child blood pressure at age 7.5 y

Brazionis¹,

Golley²,

Mittinty³

et al. 2013

The American Journal of Clinical Nutrition

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Section: Discussionsupporting

confidence: 85%

“…Birth weight and postnatal weight gain have been associated with later BP in some studies (41). However, the association we observed between the less-healthy transition diet and child BP persisted after adjustment for body size, both at birth and at measurement of BP.…”

Section: Discussioncontrasting

confidence: 48%

Diet spanning infancy and toddlerhood is associated with child blood pressure at age 7.5 y

Brazionis¹,

Golley²,

Mittinty³

et al. 2013

The American Journal of Clinical Nutrition

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“…Two studies reported positive associations between maternal age and offspring BP (27,55). A third reported differing effects for female and male offspring (56) and the fourth study reported an inverse association between maternal age at childbirth and offspring BP that disappeared after adjusting for confounders (57).…”

Section: Maternal Agementioning

confidence: 99%

Modifiable Maternal Exposures and Offspring Blood Pressure: A Review of Epidemiological Studies of Maternal Age, Diet, and Smoking

et al. 2008

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Prenatal programming of adult disease is well established in animals. In humans the impact of common in utero exposures on long-term offspring health is less clear. We reviewed epidemiology studies of modifiable maternal exposures and offspring blood pressure (BP). Three maternal exposures were identified for review and meta-analyzed where possible: smoking during pregnancy, diet, and age at childbirth. Meta-analysis suggested there was a modest association between higher offspring BP and prenatal exposure to smoke (confounder-adjusted ␤ ϭ 0.62 mm Hg, 95% confidence interval: 0.19 -1.05, I 2 ϭ 16.4%). However, the level of confounder adjustment varied between studies, which in some studies attenuated the association to the null. There was no strong evidence that any component of maternal diet during pregnancy (maternal protein, energy, calcium, and various other nutrients) influences offspring BP. The results of studies of maternal age varied and there was strong evidence of heterogeneity in the pooled analysis. The association with maternal age, if present, was modest (confounderadjusted ␤ ϭ 0.09 mm Hg/y, 95% confidence interval: Ϫ0.03 to 0.21, I 2 ϭ 89.8%). In sum, there is little empirical evidence that the maternal exposures reviewed program offspring BP. Other components of offspring health may be more susceptible to effects of programming in utero. (Pediatr Res 63: 593-598, 2008) P rogramming has been defined as to the process by which a stimulus occurring during a sensitive period of development has lasting effects on development or risk of disease (1,2). Evidence for programming is well established in animals (3) and exposures in humans, such as Rubella infection in utero (4) and inadequate periconceptual folate (5) can also result in structural changes (these might be described as teratogenic effects). However, the relevance of less extreme exposures in humans and their ability to induce adaptive responses is less clear.Interest in the role of early life and later chronic disease developed from early ecological studies by Forsdahl (6) linking infant mortality to subsequent cardiovascular disease mortality. Later studies by Barker and colleagues (1), showing that size at birth was related to adult chronic disease, extended this interest to intrauterine programming. Blood pressure (BP) is strongly and directly associated with mortality from cardiovascular disease (7), and the evidence for associations of low birth weight with adverse outcomes in later life is robust for BP (8) [although this has been disputed (9)]. In addition, there are strong cohort effects for secular changes in BP providing evidence for a role of early exposures (10,11). Thus, we have focused on BP in this review.There are various possible explanations for the association between low birth weight and later disease. These include confounding by socioeconomic position (SEP) (12), shared genes (13) and adjustment for later body size that represents programming in infancy or later in development (14). However, the association be...

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“…18 In humans, it is reasonably well established that offspring of older mothers tend to be taller [19][20][21] and have a slightly higher risk of childhood type 1 diabetes (5% per 5-year increase in mother's age, according to a meta-analysis of 30 studies). 22 However, the evidence linking mother's age at delivery with offspring blood pressure, 19,[23][24][25][26] glucose metabolism, 20,27,28 and, especially, body mass index (BMI) [19][20][21][29][30][31][32][33][34] is mixed.…”

mentioning

confidence: 99%

Mother’s age at delivery and daughters’ risk of preeclampsia

Basso

Weinberg

D’Aloisio

et al. 2019

Paediatric Perinatal Epid

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Background Some cardiovascular disease risk factors are associated with both risk of preeclampsia and having been born to a younger or older mother. We examined whether mother's age at delivery predicts a primiparous daughter's risk of preeclampsia. Methods The analysis included 39 803 Sister Study participants (designated as “daughters”) born between 1930 and 1974. Using log‐binomial regression, we estimated relative risks (RR) of preeclampsia in the first pregnancy ending in birth (“primiparous preeclampsia”) associated with mother's age at the daughter’s birth. Models included: number of older full and maternal half‐siblings, income level growing up, daughter's age at delivery, race/ethnicity, and 5‐year birth cohort. We examined self‐reported relative weight at age 10 (heavier than peers versus not) as a potential effect measure modifier. Results Overall, 6.2% of daughters reported preeclampsia. Compared with those who had been born to 20‐24‐year old mothers, daughters of teenage mothers had a relative risk of 1.20 (95% confidence interval (CI) 1.01, 1.43) and daughters of mothers ≥25 had a ~10% lower risk. Relative weight at age 10 modified the association, with an inverse association between mother's age at delivery and preeclampsia seen only among daughters with low/normal childhood relative weight. In this subset, results were consistent across strata of daughter's age at menarche and age at first birth. Conclusions These findings, based on self‐reported data, require replication. Nevertheless, as women increasingly delay childbearing, they provide some reassurance that having been born to an older mother is not, per se, a risk factor for primiparous preeclampsia.

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Maternal age in pregnancy and offspring blood pressure in childhood in the Avon Longitudinal Study of Parents and Children (ALSPAC)

Cited by 13 publications

References 25 publications

Diet spanning infancy and toddlerhood is associated with child blood pressure at age 7.5 y

Diet spanning infancy and toddlerhood is associated with child blood pressure at age 7.5 y

Modifiable Maternal Exposures and Offspring Blood Pressure: A Review of Epidemiological Studies of Maternal Age, Diet, and Smoking

Mother’s age at delivery and daughters’ risk of preeclampsia

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