Vertical transmission of antibodies in infants born from mothers with positive serology to COVID-19 pneumonia

Vendola, Nicoletta; Stampini, Viviana; Amadori, Roberta; Gerbino, Martina; Curatolo, Annalisa; Surico, Daniela

doi:10.1016/j.ejogrb.2020.08.023

Cited by 13 publications

(9 citation statements)

References 4 publications

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“…7 Although harm has not been demonstrated due to the transfer of maternal IgG antibodies to SARS-CoV-2 infection, [3][4][5]7 from anecdotal experience in older children, antibody dependent enhancement responses have been implicated in induced immune injury where low-titer neutralizing antibodies may accentuate viral triggered immune responses causing the cascade of inflammatory cytokines. [8][9][10] In our case, the transfer of maternal antibodies transplacentally and through EBM may have led to a hyperinflammatory state with cytokine storm and may have been responsible for the MIS-C like presentation.…”

Section: Discussionmentioning

confidence: 79%

COVID-19-Related Potential Multisystem Inflammatory Syndrome in Childhood in a Neonate Presenting as Persistent Pulmonary Hypertension of the Newborn

Borkotoky

Barua

Paul

et al. 2021

Pediatric Infectious Disease Journal

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Section: Discussionmentioning

confidence: 79%

COVID-19-Related Potential Multisystem Inflammatory Syndrome in Childhood in a Neonate Presenting as Persistent Pulmonary Hypertension of the Newborn

Borkotoky

Barua

Paul

et al. 2021

Pediatric Infectious Disease Journal

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“…This case spotlights the value of regular COVID-19 screening of pregnant women for specific and nonspecific symptoms of the disease prior delivery to account all required precautions and ensure safety of mothers, newborns, as well as medical staff. On the other hand, some case reports confirmed the possibility of vertical transmission due to elevated concentration of SARS-COV-2 specific antibody (IgG or IgM) in the neonatal blood serum similar to that in the infected maternal blood despite that respiratory specimens were negative 34 , 35 . This can be justified by transplacental transmission of SARS-CoV-2 IgG antibodies from mother to fetus that are inactively induced by the presumed neonatal infection 31 , 35 .…”

Section: Discussionmentioning

confidence: 99%

Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Dileep¹,

ZainAlAbdin

AbuRuz

2022

Sci Rep

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Pregnant women with COVID-19 require special attention and care, since the infection does not only affect the mother, but also her neonate and adversely affects pregnancy outcomes. The main goal of this retrospective cohort study is to investigate association between the maternal COVID-19 severity and risk of developing adverse neonatal outcomes. Patients were stratified into asymptomatic/mild and moderate to severe COVID-19. The following neonatal outcomes were assessed: gestational age at the time of delivery, birth weight, neonatal infection, neonatal intensive care unit (NICU) admission. The average age of patients was 28.5 ± 1.4 years old and majority were multigravida (74.0%, n = 148). Of total 200 pregnant women with COVID-19, 26.5% (n = 53) had moderate/severe disease and presented with higher incidence of preterm delivery and low birth weight (88.7%, n = 47; p < 0.001). In addition, more than half of the newborns delivered by mothers with severe disease were infected by SARS-COV-2 (58.5%, n = 31) and majority were admitted to the NICU (95.0%, n = 52). Based on the multivariate logistic regression analysis, pregnant women with moderate to severe COVID-19 were at much higher risk of preterm delivery, lower birth weight, neonatal infection, as well as neonatal ICU admission (p < 0.001). In addition, multigravida women were at higher risk for preterm delivery and lower birth weight (p = 0.017 and p = 0.02; respectively). Appropriate protective measures and early detection of suspected COVID-19 should be addressed for more favorable obstetric outcomes.

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“…For instance, it was reported that Covid19‐positive pregnant women show the presence of viral particles in cord blood but not in the fetuses. Therefore, it is important to deepen our focus to understand the complexity and the dynamics of the immunity of MFI 43–45 . Antibodies such as (IgG) are known to cross the placenta and have a role in providing humoral immunity in fetuses against some infectious diseases 46 .…”

Section: Role Of Fmc In the Fetal‐maternal Immune Responses During In...mentioning

confidence: 99%

Mast cells—fetal mast cells crosstalk with maternal interfaces during pregnancy: Friend or foe?

Msallam¹,

Redegeld

2023

Pediatric Allergy Immunology

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Mast cells (MC) are hematopoietic immune cells that play a major role during allergic reactions in adults by releasing a myriad of vasoactive and inflammatory mediators. MC seed all vascularized tissues and are most prominent in organs with a barrier function such as skin, lungs, and intestines. These secreted molecules cause mild symptoms such as localized itchiness and sneezing to life‐threatening symptoms (i.e., anaphylactic shock). Presently, despite the extensive research on Th2‐mediated immune responses in allergic diseases in adults, we are still unable to determine the mechanisms of the role of MC in developing pediatric allergic (PA) disorders. In this review, we will summarize the most recent findings on the origin of MC and discuss the underappreciated contribution of MC in the sensitization phase to maternal antibodies during pregnancy in allergic reactions and other diseases such as infectious diseases. Then, we will lay out potential MC‐dependent therapeutic strategies to be considered in future investigations to understand the remaining gaps in MC research for a better quality of life for these young patients.

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Vertical transmission of antibodies in infants born from mothers with positive serology to COVID-19 pneumonia

Cited by 13 publications

References 4 publications

COVID-19-Related Potential Multisystem Inflammatory Syndrome in Childhood in a Neonate Presenting as Persistent Pulmonary Hypertension of the Newborn

COVID-19-Related Potential Multisystem Inflammatory Syndrome in Childhood in a Neonate Presenting as Persistent Pulmonary Hypertension of the Newborn

Investigating the association between severity of COVID-19 infection during pregnancy and neonatal outcomes

Mast cells—fetal mast cells crosstalk with maternal interfaces during pregnancy: Friend or foe?

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