Vertical Transmission of Adult T-Cell Leukaemia Virus

Komuro, Atsumi; Hayami, Masanori; Fujii, Hitoshi; Miyahara, Shinobu; Hirayama, Motoaki

doi:10.1016/s0140-6736(83)92613-2

Cited by 66 publications

(19 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the group would appear to have sustained their exposure solely through infection in the household, possibly through maternal transmission. A role for mother to offspring transmission has been supported previously on epidemiologic grounds (13,19) by the isolation of HTLV-I in the cord blood lymphocytes of a child born to an HTLV-I positive mother (20) and by experimental oral transmission of HTLV-I into marmosets (21). If the rate of positivity observed in this study population is at all representative of the efficiency of such transmission, it certainly suggests that this is a major mode of transmission.…”

Section: Resultsmentioning

confidence: 83%

Modes of transmission and evidence for viral latency from studies of human T-cell lymphotrophic virus type I in Japanese migrant populations in Hawaii.

Blattner

Nomura

Clark

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Human T-cell lymphotrophic virus type I (HTLV-I) seroprevalence was 20% among Hawailan Japanese migrants (issei) and their offspring (nisei) from Okinawa compared to 35% in similarly aged men who were lifetime residents of Okinawa. A control group of migrants from a nonendemic area of Japan, Nligata, had low rates of HTLV-I antibodies, suggesting that Hawaiiperse is not an endemic area for HTLV-I. Factors that were significantly associated with

show abstract

Section: Resultsmentioning

confidence: 83%

Modes of transmission and evidence for viral latency from studies of human T-cell lymphotrophic virus type I in Japanese migrant populations in Hawaii.

Blattner

Nomura

Clark

et al. 1986

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…HTLV-I can be transmitted through three major routes: sexual contact (20,21); exposure to contaminated blood products, as through transfusion or needle-sharing (22,23); or mother-tochild, as through breast-feeding and transplacental or perinatal transmission (24,25). In a 5-year prospective follow-up study conducted in Miyazaki, Japan, a total of five seroconverters have been identified among married couples who were anti-HTLV-I antibody-discordant (26).…”

mentioning

confidence: 99%

“…When we examined seroreactivity to Tax among 32 concordant couples (H+,W+) randomly selected from the Miyazaki follow-up study, 24 (75%) of the men were found to be positive. This rate of reactivity is significantly higher than that (27.8%) seen in the group ofH+ ,W-discordant couples, where infected men did not transmit the virus to their wives (P= 0.0012).…”

mentioning

confidence: 99%

Sexual transmission of human T-cell leukemia virus type I associated with the presence of anti-Tax antibody.

Chen

Okayama

Lee

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The tax gene product (Tax protein) of human T-cell leukemia virus type I (EHTLV-I) is a specific transcriptional activator of the viral long terminal repeat sequence and is essential for the replication cycle of the virus. To elucidate the relationship between the presence of anti-Tax antibody and the transmission of the viral infection, annual consecutive serum samples from married couples serologically discordant or concordant for HTLV-I were examined. These included 5 individuals whose spouses seroconverted during this 5-year follow-up study period. The samples were tested by a Western blot assay using a recombinant Tax protein as the antigen. The results showed that 24 of 32 (75%) men in the concordant couples (both husband and wife were HTLV-I carriers) had anti-Tax antibody, while only 5 of 18 (27.8%) men in the discordant couples (husband was carrier and wife was seronegative to HTLV-I) were positive for anti-Tax antibody (P = 0.0012). Furthermore, all spouses of the 5 seroconverters (4 women and 1 man) had anti-Tax antibody, while only 23 of 46 (50%) age-matched randomly selected HTLV-I carriers from the discordant-couple group had anti-Tax antibody. When the data were analyzed by gender, all husbands of the female seroconverters had anti-Tax antibodies, which was signiflcantly higher than the prevalence of anti-Tax antibodies in men who did not transmit the virus to their spouses during the follow-up period (P = 0.017). In addition, antibody reactivity to other HTLV-I antigens (including Env gp46, transmembrane protein gp21, and Gag p19 and p24) were examined. The results indicated no significant difference between the prevalence of antibody reactivity to any of the antigens in the spouses of the seroconverters and the reference group. We conclude that the presence of anti-Tax antibody in men may indicate a high risk of viral transmission to their wives via heterosexual routes.

show abstract

“…A meta-analysis of over 50 randomised studies is in progress and should provide clearer guidance. 14 The risk of leukaemia remains small, and the data suggest that there is a clear benefit for some form of chemotherapy, but as prolonged treatment with alkylating agents has been shown to result in an increasing risk ofleukaemia such treatment should be avoided when possible.…”

Section: Fixed Dose Procedures For Tests On Animalsmentioning

confidence: 99%

Fixed dose procedures for tests on animals.

Dayan¹

1990

BMJ

View full text Add to dashboard Cite

Vertical Transmission of Adult T-Cell Leukaemia Virus

Cited by 66 publications

References 3 publications

Modes of transmission and evidence for viral latency from studies of human T-cell lymphotrophic virus type I in Japanese migrant populations in Hawaii.

Modes of transmission and evidence for viral latency from studies of human T-cell lymphotrophic virus type I in Japanese migrant populations in Hawaii.

Sexual transmission of human T-cell leukemia virus type I associated with the presence of anti-Tax antibody.

Fixed dose procedures for tests on animals.

Contact Info

Product

Resources

About