Vertical human immunodeficiency virus-1 infection: Involvement of the central nervous system and treatment

Exhenry, C.; Nadal, David

doi:10.1007/bf02282832

Cited by 21 publications

(10 citation statements)

References 128 publications

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“…Similar to other authors, [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] we identified two distinct groups in our cohort of long-surviving vertically HIV-1-infected: symptomatic (23 patients) and asymptomatic (6 patients). Until the age of 5 years all of our long-survivors had a similar clinical picture characterized by mild or moderate symptoms (with the exception of one case of PCP at 6 months of age); some of them subsequently progressed and presented with more serious symptoms, generally after the appearance of immunodeficiency.…”

Section: Discussionsupporting

confidence: 89%

“…5,[12][13][14][15][16][17][18] Three patients presented with dilated cardiomyopathy but, unlike other authors who described a clear connection between cardiomyopathy and antiretroviral therapy, 19 our small number of children preclude any conclusions about this association.…”

Section: Salvini Et Al 60mentioning

confidence: 90%

“…The evaluation of immunologic compromise over time confirmed the highly predictive value of CD4 1 T lymphocyte counts in terms of disease progression. [11][12][13][14][15][16][17][18][19][20][21][22][23] Among other clinical signs of progression, HIV-related encephalopathy occurred in long- survivors quite frequently, with an apparent age-dependent clinical pattern of presentation. In contrast to the stereotyped features of the early form of progressive encephalopathy, 24 the later form showed a polymorphic picture combining eye movement alterations, pyramidal signs and symptoms, and mental deterioration.…”

Section: Discussionmentioning

confidence: 99%

“…AIDS diagnoses included severe bacterial lung infections, extrapulmonary cryptococcosis, Pneumocystis carinii pneumonia (PCP), and, in two cases, HIV-related encephalopathy, diagnosed according to the accepted criteria. 16 In one child, neurologic disease started with eye movement alterations,…”

Section: Clinical and Immunologic Evaluation Of Long Survivors Until mentioning

confidence: 99%

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Follow-Up of Vertically HIV-1–Infected Long-Surviving Children

Salvini

Scarlatti

Bossi

et al. 2001

AIDS Patient Care and STDs

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This study describes the clinical, immunologic, and virological characteristics of 30 vertically human immunodeficiency virus type 1 (HIV-1)-infected children older than 8 years of age (long-survivors) before the introduction of protease inhibitors therapy. All of them were followed from birth. At the age of 8 years, 7 children presented no HIV-1-associated signs or only mild ones and only 5 had severe clinical manifestations (acquired immune deficiency virus [AIDS]). The remaining 18 children presented moderate signs with some immunodeficiency. The follow-up from 8 years of age (3.5 years on the average) showed that 6 children remained asymptomatic and were therefore defined as long-survivors nonprogressors (average, 13 years) and only 4 children developed AIDS. Progressive encephalopathy was the most striking clinical manifestation at follow-up and occurred in 6 children (always after immunodeficiency) with a polymorphic picture combining eye movement alterations, pyramidal signs and symptoms and mental deterioration. The majority of our long-survivors carried a virus with nonsyncytia-inducing phenotype, thus confirming its association with long survival. A switch to syncytia-inducing phenotype was observed only in 2 cases during the follow-up, but their clinical status did not change at follow-up.

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Section: Discussionsupporting

confidence: 89%

Section: Salvini Et Al 60mentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Clinical and Immunologic Evaluation Of Long Survivors Until mentioning

confidence: 99%

See 2 more Smart Citations

Follow-Up of Vertically HIV-1–Infected Long-Surviving Children

Salvini

Scarlatti

Bossi

et al. 2001

AIDS Patient Care and STDs

View full text Add to dashboard Cite

show abstract

“…Involvement of the central nervous system (CNS) contributes substantially to morbidity and mortality of infection with the human immunodeficiency virus (HIV) [5]. The main neurological condition related to HIV infection in childhood is HIV-associated progressive encephalopathy, which may be the initial presenting condition for AIDS in 18% of cases.…”

Section: Introductionmentioning

confidence: 99%