Vertebrate extracellular calcium-sensing receptor evolution: Selection in relation to life history and habitat

Herberger, Amanda L.; Loretz, Christopher A.

doi:10.1016/j.cbd.2012.12.004

Cited by 27 publications

(22 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the large repertoire of ligands that can activate CaSR, it is likely that protoCaSR was a pheromone or an odor receptor. Through adaptive evolution, CaSR may have become more specialized to extracellular free calcium (22). When some vertebrates migrated into fresh water and then onto ground during evolution, they needed to adapt to a low calcium milieu (27).…”

Section: Is the Kidney A Calcium-sensing Organ?mentioning

confidence: 99%

“…The length of the intracellular domain (ICD) differs noticeably among the various clades. Only the CaSR analogs of cephalochordates and tetrapods contain sequence insertions (22), whose function is presently unknown. In contrast, the sequences corresponding to calcium-binding sites within the extracellular domain of human CaSR are highly conserved in vertebrates (26).…”

Section: Is the Kidney A Calcium-sensing Organ?mentioning

confidence: 99%

See 1 more Smart Citation

Calcium Sensing in the Renal Tubule

2015

View full text Add to dashboard Cite

show abstract

Section: Is the Kidney A Calcium-sensing Organ?mentioning

confidence: 99%

Section: Is the Kidney A Calcium-sensing Organ?mentioning

confidence: 99%

Calcium Sensing in the Renal Tubule

2015

View full text Add to dashboard Cite

show abstract

“…The strong structural conservation of CaSR throughout evolution is suggested by the high similarity in sequences across all the vertebral classes (58). Birds also express CaSR, as demonstrated by the cloning of a full-length calcium receptor from the chicken parathyroid (37).…”

Section: Primitive Receptor Found In a Variety Of Animals And Fishmentioning

confidence: 99%

“…The length of the ICD differs markedly among the various clades. Only the cephalochordates and the tetrapods CaSR contains insertion sequences (58). By contrast, the sequence of the putative calcium-binding sites within the ECD among the vertebrates remains remarkably conserved (63).…”

Section: Primitive Receptor Found In a Variety Of Animals And Fishmentioning

confidence: 99%

Calcium-sensing receptor 20 years later

Alfadda

Saleh

Houillier

et al. 2014

American Journal of Physiology-Cell Physiology

View full text Add to dashboard Cite

The calcium-sensing receptor (CaSR) has played an important role as a target in the treatment of a variety of disease states over the past 20 plus years. In this review, we give an overview of the receptor at the cellular level and then provide details as to how this receptor has been targeted to modulate cellular ion transport mechanisms. As a member of the G proteincoupled receptor (GPCR) family, it has a high degree of homology with a variety of other members in this class, which could explain why this receptor has been identified in so many different tissues throughout the body. This diversity of locations sets it apart from other members of the family and may explain how the receptor interacts with so many different organ systems in the body to modulate the physiology and pathophysiology. The receptor is unique in that it has two large exofacial lobes that sit in the extracellular environment and sense changes in a wide variety of environmental cues including salinity, pH, amino acid concentration, and polyamines to name just a few. It is for this reason that there has been a great deal of research associated with normal receptor physiology over the past 20 years. With the ongoing research, in more recent years a focus on the pathophysiology has emerged and the effects of receptor mutations on cellular and organ physiology have been identified. We hope that this review will enhance and update the knowledge about the importance of this receptor and stimulate future potential investigations focused around this receptor in cellular, organ, and systemic physiology and pathophysiology.G protein-coupled receptors; calcimimetics; kidney; gastrointestinal tract; divalent ions IT IS NOW 20 YEARS since the initial review on calcium-sensing receptor (CaSR) was published (17). The initial review focused on the preliminary characterization and description of the receptor and how it related to the parathyroid and whole body calcium handling and homeostasis (17). Since that time, not only has there been a great deal of new information concerning CaSR and parathyroid disease come to light, but in addition the receptor has now been identified in many other tissues and organs in the body where it has been shown to have a diverse role in cellular and organismic pathophysiology (1, 2, 24, 28). With the further identification and functional characterization of the receptor in multiple organ systems and at the cellular level (Fig. 1), we felt it was now time to provide an updated overview of the calcium-sensing receptor and its diverse functions throughout the body.Our review will give a brief historical review of the identification of the receptor in the parathyroid and its role as an important target for parathyroid disease. We include a discussion of the initial cloning studies and the ability of this receptor to "sense" divalent and trivalent ions in the extracellular environment. We follow this with a molecular profile of the receptor based on the many years of research into the structure and function of the receptor. In te...

show abstract

“…11 The presence of CaSR is confirmed in all vertebrate classes by the high similarity in nucleotide sequences across all the vertebrate classes. 12 Others tetrapods (e.g., birds, amphibians, mammals, and reptiles) have evolved a CaSR-based fully orchestrated homeostatic system intended to maintain a nearly constant level of the extracellular ionized calcium concentration. 13,14 More unexpected, perhaps, is the expression of a gene homologous to CaSR in animals that do not have parathyroid glands, such as teleost, elasmobranch fish, and dogfish shark.…”

Section: Introductionmentioning

confidence: 99%

Calcium-Sensing Receptor

Ray¹

2015

Progress in Molecular Biology and Translational Science

View full text Add to dashboard Cite

Vertebrate extracellular calcium-sensing receptor evolution: Selection in relation to life history and habitat

Cited by 27 publications

References 46 publications

Calcium Sensing in the Renal Tubule

Calcium Sensing in the Renal Tubule

Calcium-sensing receptor 20 years later

Calcium-Sensing Receptor

Contact Info

Product

Resources

About