Vertebral fractures and bone mineral density in patients with idiopathic hypoparathyroidism on long term follow-up

Abstract

Despite increased BMD, prevalence of vertebral-fractures is greater in patients with IH, especially in postmenopausal women and those on anticonvulsant therapy.

Incidence of parathyroid disorders in Indian adult male population: A 25‐year follow‐up study

“…Our patients were operated on at different places by different surgeons, which could have contributed to the high rate of hypoparathyroidism. The median age of presentation of PHPT and SIHP was similar to other published reports from India . PHPT is reported to be more common in females; however, our data pertain to male subjects only, precluding any comparison .…”

“…Previous published reports from major academic institutes show data pertaining to a few hundred patients with parathyroid disorders over a long‐term follow‐up . This suggests the presence of a huge burden of undiagnosed disease in the community, and there is an urgent requirement of identifying them to prevent morbidity and mortality.…”

Diagnosis and treatment of hypoparathyroidism: a position statement from the Brazilian Society of Endocrinology and Metabolism

“…The risk of fractures, in general, has been described as comparable to that in control populations (34,145). A pioneer prospective study with radiological assessment of vertebral fractures has shown increased morphometric fractures in women with postsurgical hypoparathyroidism (B) (153), a finding confirmed by other authors (154). Monitoring of bone mass using dual-energy X-ray absorptiometry (DXA) has little value during long-term follow-up of patients with hypoparathyroidism, noting that the BMD tends to increase with the duration of the disease (155).…”

A paternally inherited non‐sense variant c.424G>T (p.G142*) in the first exon of XLαs in an adult patient with hypophosphatemia and osteopetrosis

“…It is well known that primary hyperparathyroidism causes increased bone turnover and reduced BMD, especially at the cortical bone . On the contrary, idiopathic hypoparathyroidism (IHP) cases often have reduced bone turnover and increased BMD, mainly at the trabecular, than the general population . Compared with IHP and non‐surgical hypoparathyroidism patients, PHP subjects, especially pseudohypoparathyroidism type 1b (PHP1B), tend to have lower BMD, indicating incomplete skeletal resistance to PTH may exist .…”