Versuche über die Uebertragung der Carcinome von Thier auf Thier

Doutrelepont,

doi:10.1007/bf01923811

Cited by 3 publications

(1 citation statement)

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“…Mention should be made of the studies over a century ago that involved tumor transplantations to humans [423][424][425], with the heroic trial by Senn who inoculated himself with pieces of cancerous lymph nodes [7,425]. Moreover, as reviewed by Triolo [7], transplantation of animal tumors to other animals have also been performed since in 1860s [426][427][428][429][430]. The rationale for this approach is to use tumor cells' behaviors, mainly autonomy, to determine its authenticity.…”

Section: Tissue Culture and Transplantation Were Once Used To Determimentioning

confidence: 99%

Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology

Dou¹,

Tong²,

Huang³

et al. 2020

J. Cancer

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Modern research into carcinogenesis has undergone three phases. Surgeons and pathologists started the first phase roughly 250 years ago, establishing morphological traits of tumors for pathologic diagnosis, and setting immortality and autonomy as indispensable criteria for neoplasms. A century ago, medical doctors, biologists and chemists started to enhance "experimental cancer research" by establishing many animal models of chemical-induced carcinogenesis for studies of cellular mechanisms. In this second phase, the two-hit theory and stepwise carcinogenesis of "initiation-promotion" or "initiation-promotion-progression" were established, with an illustrious finding that outgrowths induced in animals depend on the inducers, and thus are not authentically neoplastic, until late stages. The last 40 years are the third incarnation, molecular biologists have gradually dominated the carcinogenesis research fraternity and have established numerous genetically-modified animal models of carcinogenesis. However, evidence has not been provided for immortality and autonomy of the lesions from most of these models. Probably, many lesions had already been collected from animals for analyses of molecular mechanisms of "cancer" before the lesions became autonomous. We herein review the monumental work of many predecessors to reinforce that evidence for immortality and autonomy is essential for confirming a neoplastic nature. We extrapolate that immortality and autonomy are established early during sporadic human carcinogenesis, unlike the late establishment in most animal models. It is imperative to resume many forerunners' work by determining the genetic bases for initiation, promotion and progression, the genetic bases for immortality and autonomy, and which animal models are, in fact, good for identifying such genetic bases.

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Section: Tissue Culture and Transplantation Were Once Used To Determimentioning

confidence: 99%

Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology

Dou¹,

Tong²,

Huang³

et al. 2020

J. Cancer

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Ueber Psorospermien bei Hautkrankheiten. (Bericht über einen typischen Fall von sog. Darier'scher Psorospermose)

Fabry¹

1894

Arch. f. Dermat.

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Die vor noch nicht so sehr langer Zeit beschriebene Psorospermosis Darier's ist eine derjenigen Dermatonoseno far welche yon einem Theil wenigstens der Autoren Psorospermien als die grankheitserreger aufgefunden und hingestellt wurden; beim ngheren Eingehen auf die Literatur werden wir die Stimmen fiir und gegen diese Theorie hSren.Da wir nun in der gliicklichen Lage waren, einen zweifeltosen Fall yon D arier'scher Krankheit nnter den Patienten des hiesigen stgdtisclien Krankenhauses durch mehrere Jahre his zu dem wegen anderweitiger Erkrankung erfolgten Tode beobachten zu k5nnen und selbstverst~ndlich die klinische Beobachtung durch vielfache histologische Untersuchungen zu completiren, so dfirfte eine ausfiihrliche Berichterstattung fiber den Krankheitsverlauf schon in Anbetracht der Seltenheit dieser Erkrankung angezeigt erscheinen. Unseres Wissens stellt unser Fall den 4. in Deutschland beobachteten, dazu gerechnet ist dabei derSchwimmer'sche Fall, fiber den Neisser aufdem Dermatologen-Congress 1891 berichtete; die Zahl der fiber-:haupt verSffentlichten F~lle diirfte nicht mehr wie ein Dutzend betragen.Aus vielfachen Erwggungen schien es uns zweckm~ssig, aus der Literatur auch diejenigen Affectionen mitzuberiicksich-

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Fall von Leukämie

Reincke¹

1870

Archiv f. pathol. Anat.

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Versuche über die Uebertragung der Carcinome von Thier auf Thier

Cited by 3 publications

References 0 publications

Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology

Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology

Ueber Psorospermien bei Hautkrankheiten. (Bericht über einen typischen Fall von sog. Darier'scher Psorospermose)

Fall von Leukämie

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