Versatility of a carbon paste electrode coupled to differential pulse voltammetry for determination of lisinopril with its associations (hydrochlorothiazide and amlodipine)

Abstract

This work describes two analytical methods for the determination of pairs of antihypertensives using a carbon paste electrode coupled with differential pulse voltammetry.

Introduction of AlV3O9/CNT Nanocomposite for Modification of the Electrochemical Sensor in Order the Determination of Amlodipine and Hydrochlorothiazide in Biological and Pharmaceutical Samples

“…According to the results, the change in I pa causes the shift of E p to more positive values by increasing the scan rate values from 10 to 450 mV/s. The linear corrolation between I pa and υ also indicates that the electrochemical behavior of AML and HCTZ at the surface of AlV 3 O 9 /CNT/CPE is affected by the diffusion process. , The resulting linear relation is presented below (Figures c and c): …”

“…To survey the influence of potential scan rate (υ) on the electrochemical behavior of AML and HCTZ at the surface of AlV 3 O 9 /CNT/ CPE, cyclic voltammograms of these two drugs with a concentration of 0.01 M were recorded in phosphate buffer (0.1 M, pH = 7.0) at different values of scan rate of 10, 30, 50, 80, and υ also indicates that the electrochemical behavior of AML and HCTZ at the surface of AlV 3 O 9 /CNT/CPE is affected by the diffusion process. 14,33 The resulting linear relation is presented below (Figures 8c and 9c): In addition, there is a relation between E p and the logarithm of the scan rates (log υ) in both AML and HCTZ, which is described as follows (see Figures 8c and 9c): Linear deviation determined by the error bar is 0.2%. According to the Laviron equation for irreversible electrode processes, the slope value E p versus log υ for the anodic peak is obtained from the relation 2.303RT/(1 − α)nF.…”

“…HCTZ may be used to prevent kidney stones , and treat diabetes insipidus and edema caused by various diseases . A combination of two drugs, AML and HCTZ, can be widely used to reduce or control blood pressure. − …”

Spectrophotometric Determination of Lisinopril Drug by Oxidative Coupling Reaction with 4-aminonaphthalene-1- sulfonic acid Reagent

“…Various analytical methods for determining lisinopril have been reported, including spectrofluorimetry [12], chemiluminescence [13], potentiometric titration [14], capillary zone electrophoresis [15], reverse phase-high-performance liquid chromatography [16] micellar electrokinetic chromatography [17] spectrophotometry [18] differential pulse voltammetry [19], and fluorescence [20]. In this work oxidative coupling method is proposed to determine Lisinopril in Pharmaceutical Preparations by coupling reaction with 4aminonaphthalene-1-sulfonic acid in presence of potassium peroxydisulfate as oxidation agent to form a green color product dissolved in water.…”