“…The porous structure of this hydrogel and its high affinity for contaminants can effectively enhance the adsorption of trace carcinogens PAH (BaP and coronene). [70] Moreover, DNA hydrogels can also act as a 3D shelter for catalytically active nanozymes to produce catalytically active hydrogels. [71] Wang et al have developed a catalytically active DNA hydrogel based on metal-organic framework (MOFzyme) and hyaluronic acid (HA) for sensitive and accurate quantification of zearalenone.…”
Section: Constructing Dna Hydrogels With Antibacterial Propertiesmentioning
With the extensive attention of DNA hydrogels in biomedicine, biomaterial, and other research fields, more and more functional DNA hydrogels have emerged to match the various needs. Incorporating nanomaterials into the hydrogel network is an emerging strategy for functional DNA hydrogel construction. Surprisingly, nanomaterials‐based DNA hydrogels can be engineered to possess favorable properties, such as dynamic mechanical properties, excellent optical properties, particular electrical properties, perfect encapsulation properties, improved magnetic properties, and enhanced antibacterial properties. Herein, the preparation strategies of nanomaterials‐based DNA hydrogels are first highlighted and then different nanomaterial designs are used to demonstrate the functional regulation of DNA hydrogels to achieve specific properties. Subsequently, representative applications in biosensing, drug delivery, cell culture, and environmental protection are introduced with some selected examples. Finally, the current challenges and prospects are elaborated. The study envisions that this review will provide an insightful perspective for the further development of functional DNA hydrogels.
“…The porous structure of this hydrogel and its high affinity for contaminants can effectively enhance the adsorption of trace carcinogens PAH (BaP and coronene). [70] Moreover, DNA hydrogels can also act as a 3D shelter for catalytically active nanozymes to produce catalytically active hydrogels. [71] Wang et al have developed a catalytically active DNA hydrogel based on metal-organic framework (MOFzyme) and hyaluronic acid (HA) for sensitive and accurate quantification of zearalenone.…”
Section: Constructing Dna Hydrogels With Antibacterial Propertiesmentioning
With the extensive attention of DNA hydrogels in biomedicine, biomaterial, and other research fields, more and more functional DNA hydrogels have emerged to match the various needs. Incorporating nanomaterials into the hydrogel network is an emerging strategy for functional DNA hydrogel construction. Surprisingly, nanomaterials‐based DNA hydrogels can be engineered to possess favorable properties, such as dynamic mechanical properties, excellent optical properties, particular electrical properties, perfect encapsulation properties, improved magnetic properties, and enhanced antibacterial properties. Herein, the preparation strategies of nanomaterials‐based DNA hydrogels are first highlighted and then different nanomaterial designs are used to demonstrate the functional regulation of DNA hydrogels to achieve specific properties. Subsequently, representative applications in biosensing, drug delivery, cell culture, and environmental protection are introduced with some selected examples. Finally, the current challenges and prospects are elaborated. The study envisions that this review will provide an insightful perspective for the further development of functional DNA hydrogels.
“…131 Hydrogels based on DNA could be made using pristine DNA or DNA as a chief source material to control the gelation behavior of the hybrid DNA gels. 206,207 Interestingly, the macroscopical hydrogel behavior of DNA can be tuned by rationally controlling the responsive nature of DNA, nanoscale internal architecture, and also other functional motifs of the DNA sequences. 46,208 Taking advantage of these unique features, research has been conducted on various applications of DNA hydrogels such as tissue engineering, cell targeting, drug delivery, and immunotherapy.…”
Section: Current Challenges In Using Dna For Bioprintingmentioning
DNA has excellent features such as the presence of functional and targeted molecular recognition motifs, tailorable, defined material source, multifunctionality, high–precision molecular self–assembly, synthetic preparation, hydrophilicity and outstanding biocompatibility. Due...
“…The method is simple and efficient, which can meet the needs of mass production of DNA-based hydrogels, and has a good application prospect in the field of tissue engineering ( Zinchenko et al, 2015 ). Meanwhile, a similar method was also used to prepare a highly porous DNA/MWCNT hybrid hydrogel ( Ma et al, 2021 ). In this study, oil-in-water Pickering emulsion was first continuously produced inside DNA/MWCNT/EGDE mixture solution under shaking.…”
Section: The Preparation Of Dna-based Hybrid Hydrogelsmentioning
Hydrogels have outstanding research and application prospects in the biomedical field. Among them, the design and preparation of biomedical hydrogels with deoxyribonucleic acid (DNA) as building blocks have attracted increasing research interest. DNA-based hydrogel not only has the skeleton function of hydrogel, but also retains its biological functions, including its excellent selection specificity, structural designability, precise molecular recognition ability, outstanding biocompatibility, and so on. It has shown important application prospects in the biomedical field, such as drug delivery, biosensing, and tissue engineering. In recent years, researchers have made full use of the characteristics of DNA molecules and constructed various pure DNA-based hydrogels with excellent properties through various crosslinking methods. Moreover, via introducing functional molecules or elements, or combining with other functional materials, a variety of multifunctional DNA-based hybrid hydrogels have also been constructed, which expand the breadth and depth of their applications. Here, we described the recent development trend in the area of DNA-based hydrogels and highlighted various preparation methods of DNA-based hydrogels. Representative biomedical applications are also exemplified to show the high performance of DNA-based hydrogels. Meanwhile, the existing problems and prospects are also summarized. This review provided references for the further development of DNA-based hydrogels.
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