Versatile Pectin Grafted Poly (N-isopropylacrylamide); Modulated Targeted Drug Release

Assaf, Shereen M.; Abul‐Haija, Yousef M.; Fares, Mohammad M.

doi:10.1080/10601325.2011.573374

Cited by 20 publications

(8 citation statements)

References 36 publications

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“…Such results clearly demonstrated that pectin is strongly bonded to polycaprolactone in large amounts of crystalline PGP that decomposed at 400°C, and consequently, very small amounts of amorphous PGP exist. In previous works, amorphous or low‐crystalline pectin grafted polymers showed split of decomposition peaks of pectin and other polymers . Such results came in accordance with high percentage of crystallinity of PGP determined in DSC results and also with ATR‐FTIR results.…”

Section: Resultssupporting

confidence: 87%

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π‐Plasmon absorbance films of carboxylic functionalized CNTs coupled with renewable PGP platforms

Fares

2018

Polymers for Advanced Techs

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π‐Plasmon absorbance films of carboxylic functionalized multiwall carbon nanotubes (CNTs) coupled with renewable and recycled polycaprolactone grafted pectin (PGP) platforms as successful alternative for ordinary nondegradable platforms were investigated. Characterization of the synthesized carboxylic functionalized CNTs was performed using 1H NMR and attenuated total reflectance Fourier transform infrared for structural identification, thermogravimetric analysis and derivative thermogravimetric analysis for thermal stability, and X‐ray powder diffraction for crystal structure, whereas the characterization of prepared PGP was done by means of attenuated total reflectance Fourier transform infrared for chemical structure, differential scanning calorimetry for melting endotherms of polycaprolactone and high crystalline structure of PGP, and thermogravimetric analysis and derivative thermogravimetric analysis for thermal stability of PGP. Fabrication of water‐dispersed carboxylic functionalized CNTs coupled with PGP films was performed by casting technique in the presence of Ca2+ as cross‐linker. The thin films were tested for π‐plasmon absorbance using UV‐Vis spectrometry. Different fractions of carboxylic functionalized CNTs and PGP films demonstrated π‐plasmon absorbance broad peaks at λmax = 232 nm, which corresponded to 5.36 eV. The fabrication of novel films from renewable recycled PGP platform and advanced carboxylic functionalized CNTs properties will be the key features for many of next forthcoming technologies. The PGP considered as environment‐friendly and easily degradable platforms will be a successful alternative for conventional nondegradable electronic platforms, and water‐dispersed carboxylic functionalized CNTs with advanced properties will be finding accelerating executive applications.

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Section: Resultssupporting

confidence: 87%

“…In previous works, amorphous or low-crystalline pectin grafted polymers showed split of decomposition peaks of pectin and other polymers. [50][51][52] Such results came in accordance with high percentage of crystallinity of PGP determined in DSC results and also with ATR-FTIR results.…”

Section: High Crystalline and High Thermally Stable Pgpsupporting

confidence: 88%

π‐Plasmon absorbance films of carboxylic functionalized CNTs coupled with renewable PGP platforms

Fares

2018

Polymers for Advanced Techs

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“…Pectin is a polyuronate heteropolysaccharide naturally found in the primary cell walls of terrestrial plants, which consists of partially esterified D-galacturonic acid residues in α-(1 → 4) chains. 24 Due to its simple, fast, and cytocompatible gelling mechanism, pectin has been widely used for drug delivery [25][26][27] and bone tissue engineering applications. [28][29][30][31][32] Pectin composites have been shown to exhibit high cytocompatibility in vitro, and to support the proliferation of various cell types such as NIH3T3 33 and L929 mouse fibroblasts, 34 as well as human dermal fibroblasts (HDF).…”

Section: Introductionmentioning

confidence: 99%

Interpenetrating network gelatin methacryloyl (GelMA) and pectin-g-PCL hydrogels with tunable properties for tissue engineering

et al. 2018

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The design of new hydrogel-based biomaterials with tunable physical and biological properties is essential for the advancement of applications related to tissue engineering and regenerative medicine. For instance, interpenetrating polymer network (IPN) and semi-IPN hydrogels have been widely explored to engineer functional tissues due to their characteristic microstructural and mechanical properties. Here, we engineered IPN and semi-IPN hydrogels comprised of a tough pectin grafted polycaprolactone (pectin-g-PCL) component to provide mechanical stability, and a highly cytocompatible gelatin methacryloyl (GelMA) component to support cellular growth and proliferation. IPN hydrogels were formed by calcium ion (Ca2+)-crosslinking of pectin-g-PCL chains, followed by photocrosslinking of the GelMA precursor. Conversely, semi-IPN networks were formed by photocrosslinking of the pectin-g-PCL and GelMA mixture, in the absence of Ca2+ crosslinking. IPN and semi-IPN hydrogels synthesized with varying ratios of pectin-g-PCL to GelMA, with and without Ca2+-crosslinking, exhibited a broad range of mechanical properties. For semi-IPN hydrogels, the aggregation of microcrystalline cores led to formation of hydrogels with compressive moduli ranging from 3.1 to 10.4 kPa. For IPN hydrogels, the mechanistic optimization of pectin-g-PCL, GelMA, and Ca2+ concentrations resulted in hydrogels with comparatively higher compressive modulus, in the range of 39 kPa-5029 kPa. Our results also showed that IPN hydrogels were cytocompatible in vitro and could support the growth of three-dimensionally (3D) encapsulated MC3T3-E1 preosteoblasts in vitro. The simplicity, technical feasibility, low cost, tunable mechanical properties, and cytocompatibility of the engineered semi-IPN and IPN hydrogels highlight their potential for different tissue engineering and biomedical applications.

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“…Poly( N -isopropylacrylamide) grafted pectin was studied as a potential device for colon targeted delivery of theophylline (Figure ). The gels were prepared by using ceric ammonium nitrate as initiator and N , N ′-methylenebis(acrylamide) as cross-linker. The hydrogel showed maximum drug release at pH 7.4 and minimum at pH 5.5, without thermosensitive behavior.…”

Section: Edible Polymers Based Hydrogelsmentioning

confidence: 99%

Recent Advances in Edible Polymer Based Hydrogels as a Sustainable Alternative to Conventional Polymers

Ali

Ahmed²

2018

J. Agric. Food Chem.

219

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The over increasing demand of eco-friendly materials to counter various problems, such as environmental issues, economics, sustainability, biodegradability, and biocompatibility, open up new fields of research highly focusing on nature-based products. Edible polymer based materials mainly consisting of polysaccharides, proteins, and lipids could be a prospective contender to handle such problems. Hydrogels based on edible polymer offer many valuable properties compared to their synthetic counterparts. Edible polymers can contribute to the reduction of environmental contamination, advance recyclability, provide sustainability, and thereby increase its applicability along with providing environmentally benign products. This review is highly emphasizing on toward the development of hydrogels from edible polymer, their classification, properties, chemical modification, and their potential applications. The application of edible polymer hydrogels covers many areas including the food industry, agricultural applications, drug delivery to tissue engineering in the biomedical field and provide more safe and attractive products in the pharmaceutical, agricultural, and environmental fields, etc.

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Versatile Pectin Grafted Poly (N-isopropylacrylamide); Modulated Targeted Drug Release

Cited by 20 publications

References 36 publications

π‐Plasmon absorbance films of carboxylic functionalized CNTs coupled with renewable PGP platforms

π‐Plasmon absorbance films of carboxylic functionalized CNTs coupled with renewable PGP platforms

Interpenetrating network gelatin methacryloyl (GelMA) and pectin-g-PCL hydrogels with tunable properties for tissue engineering

Recent Advances in Edible Polymer Based Hydrogels as a Sustainable Alternative to Conventional Polymers

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