Verrucous Carcinoma of the Pyriform Sinus

Thomas, John R.; Snyderman, Sanford C.; Giffin, Charles S.; Goin, Donald W.

doi:10.1001/archotol.1973.00780010502014

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…As to the larynx, it can be asserted that metastases to the cervical nodeshave never occurred. Prophylactic radical neck dissection is therefore not indicated in the surgical treatment of the verrucous squamous cell carcinoma (29,30,39).…”

Section: Discussionmentioning

confidence: 99%

Histological Appearances and Nuclear DNA Content of Verrucous Squamous Cell Carcinoma of the Larynx

Ferlito¹,

Antonutto²,

Silvestri³

1976

ORL

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Of the 12 cases of verrucous squamous cell carcinoma of the larynx encountered since 1968 at the Department of Otolaryngology of Padua University (including the Verona Section) and the Department of Pathologic Anatomy of the University of Trieste, three are reported, together with an investigation of the nuclear DNA content of the tumour cells. It is suggested that such a study may assist with early detection of verrucous carcinoma. The laryngeal localization of the neoplasm has been evidenced only in some centres. The difficulties in establishing a correct diagnosis for this variant of squamous cell carcinoma are emphasized and the pathomorphological features, as well as the microscopic and macroscopic appearances, are discussed. The prognosis is excellent and the therapy of choice must be only surgical, as radiation has not only proven ineffective, but in some cases has induced anaplasia, leading to a rapid dissemination of the tumour.

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Section: Discussionmentioning

confidence: 99%

Histological Appearances and Nuclear DNA Content of Verrucous Squamous Cell Carcinoma of the Larynx

Ferlito¹,

Antonutto²,

Silvestri³

1976

ORL

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Ackerman's tumor (verrucous carcinoma) of the larynx. A clinicopathologic study of 77 cases

Ferlito

Recher

1980

Cancer

152

103

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A series of 77 cases of verrucous carcinoma of the larynx is presented. The tumor is relatively rare and the present series has been selected from 2,398 primary and recurrent malignant neoplasms of the larynx and hypopharynx evaluated at the Department of Otolaryngology of Padua University during the period from January 1966 to December 1978. The median age of patients was 58 years. The tumor appears to be exophytic, broadly implanted and fungating in aspect, with papillary fronds and a locally invasive character. It is composed of highly differentiated epithelial squamous cells covered by a thick keratinized layer arranged in deeply invaginated folds. Cellular response in tumor stroma is marked, and the neoplasm has a low‐grade malignancy. Close cooperation between the pathologist and the clinician is needed in order to establish the nature of the lesion, which looks clinically malignant but may appear histologically benign. Benign responses such as hyperkeratosis, acanthosis, or the presence of a benign papillomatous area necessitate further investigation with another biopsy examination from deeper layers. The elective treatment is surgery, as irradiation may cause anaplastic transformation with metastatic spread. Neck dissection is not indicated as this laryngeal tumor has so far never metastasized to cervical lymph nodes or to other organs.

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