Verruciform xanthoma of the penis: A rare benign lesion that simulates carcinoma

Abstract

Verruciform xanthoma is a rare and benign condition predominantly affecting the oral cavity, but also skin and female anogenital mucosa. It can be flat, papular-warty or crateriform-cystic. Furthermore it can simulate HPV viral lesion such as condyloma and malignant neoplasia such as verrucous squamous cell carcinoma. An accurate diagnosis is important to avoid overtreatment, considering it is a benign lesion that does not require any radical treatment. We present an extremely rare case of a 64 year-old man with a small, slighty raised, gray reddish-dotted lesion on the left portion of the ventral side of his glans.

Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region

“…89 Not surprisingly, the clinical morphology often raises concern for condyloma acuminatum or verrucous carcinoma. 89,90 In a study of 10 vulvar verruciform xanthomas, all were associated with vulvar inflammatory or neoplastic conditions including lichen sclerosus, lichen planus, Paget disease, and radiodermatitis. 89 Although HPV has been proposed in the past as the etiologic agent, multiple studies have failed to confirm a causal relationship.…”

Penile verruciform xanthoma mimicking large genital wart

“…Verruciform xanthoma is rarely seen on the genital area, especially on the penis. The penile verruciform xanthoma was first reported in 1981 by Kraemer et al 1,2 We herein describe a case of penile verruciform xanthoma with a discussion of both clinical and histologic hallmarks.…”

“…A typical lesion of penile verruciform xanthoma is a wart‐like yellowish papule or nodule with a verrucous surface 2,3 . The lesion may present in a broad range of colors, therefore, it is usually misdiagnosed with condyloma acuminatum.…”

“…A typical lesion of penile verruciform xanthoma is a wartlike yellowish papule or nodule with a verrucous surface. 2,3 The lesion may present in a broad range of colors, therefore, it is usually misdiagnosed with condyloma acuminatum. Interestingly, a yellowish hue may be differentiated with other tumoral lesions including condyloma acuminatum.…”

Giant verruciform tumour on the penis

“…Verrucous xanthoma is a rare benign disease that predominantly affects the oral cavity 1. Involvement of the glans penis is uncommon 1.…”