Verruciform xanthoma of the lip: A rarity

Pereira, Treville; Shetty, Subraj; Dodal, Shashibhushan; Tamgadge, Avinash

doi:10.4103/2229-5178.182356

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Importantly, oral VX are rarely reported to extend to cutaneous surfaces, areas not as likely to be traumatized. However, along with other studies, our study also had rare cutaneous VX [21][22][23][24][25][26]. Floor of the mouth is an even more unusual location for VX [21] with 1.42% (n = 3) lesions seen in here.…”

Section: Intra-oral Locationsupporting

confidence: 78%

Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature

Belknap

Islam

Bhattacharyya

et al. 2020

Head and Neck Pathol

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Verruciform xanthoma (VX) of the oral cavity is an uncommon, reactive lesion of unknown etiology. In this study, we present a large series of VX with analysis of demographics, clinical appearance, histologic presentation and extensive review of literature. To the best of our knowledge, this is the largest series of oral VX reported to date. Following IRB approval, all cases diagnosed as VX found in the archives of the University of Florida Oral Pathology Biopsy Service were included. Patient age, gender, location, clinical appearance, clinical impression, and duration of each lesion was collected. A total of 212 cases were included in our database with a mean age of 61 years (range of 9-94), and a female: male ratio of 1.06:1. The most common location in descending order was the gingiva (n = 110, 51.2%), followed by palate (n = 41, 19.3%), buccal mucosa (n = 18, 8.5%), tongue (n = 20, 9.4%), vestibule (n = 13, 6.1%), lip (n = 4, 1.9%), floor of mouth (n = 3, 1.4%), and unspecified (n = 1, 0.5%). The lesions were most frequently pink in color, and most often described as bumpy, rough, verrucoid and/or papillary. Clinical impression in descending order was papillary (n = 67, 31.6%), not specified or unknown (n = 41, 19.3%), hyperkeratosis (n = 24, 11.3%), fibroma (n = 20, 9.4%), leukoplakia (n = 17, 8.0%), dysplastic lesion (n = 13, 6.1%), pyogenic granuloma (n = 7, 3.3%), granulomatous reaction (n = 5, 2.4%), lichen planus, VX (n = 4 each, 2.0%), pigmented, other lesions (n = 3 each, 1.4%), and salivary and periapical lesions (n = 2 each, 0.9%). Three of the lesions were recurrences. The demographics and clinical parameters of this case series were in concordance with that of previously published reports. In our series, only 4 cases were suspected as VX, demonstrating the lack of familiarity clinicians have with this lesion.

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Section: Intra-oral Locationsupporting

confidence: 78%

Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature

Belknap

Islam

Bhattacharyya

et al. 2020

Head and Neck Pathol

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“…There are only 5 articles published in the English-language literature. This study reports the sixth case of cutaneous verruciform xanthoma of the lower lip published worldwide to date [ 1 , 2 , 3 , 9 , 10 ]. We present the characteristics of these cases with addition of the present study in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

Verruciform Xanthoma of a Lower Lip Lesion: A New Case and Review of the Literature

et al. 2017

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A non-smoking man in his seventh decade presented with a lesion he had had for about 5 years on the right external surface of the lip 1 mm from the vermilion border. On physical examination, a yellowish-coloured, non-tender, verrucous mass of 0.5 × 0.7 cm was observed. A histopathological examination of the first 3-mm punch biopsy was non-diagnostic. The histopathological evaluation of a second, 5-mm-deep punch biopsy made by a pathology expert in oral lesions revealed a diagnosis of verruciform xanthoma. The key to the diagnosis of verruciform xanthoma is to recognize xanthoma cells. However, these cells may be insufficient in number in small and superficial biopsy material and overlooked by a pathologist especially when lacking knowledge of this uncommon lesion. Verruciform xanthoma of the lower lip at the vermilion border is an extremely rare entity described in 5 cases worldwide to date. We aimed to bring verruciform xanthoma to readers’ attention for a differential diagnosis of lower lip diseases and to prevent overdiagnosis and overtreatment of this lesion unfamiliar to otorhinolaryngologists.

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Introduction to Oral Cancer

Panta

Andreadis

2019

Oral Cancer Detection

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Verruciform xanthoma of the lip: A rarity

Cited by 5 publications

References 11 publications

Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature

Oral Verruciform Xanthoma: A Series of 212 Cases and Review of the Literature

Verruciform Xanthoma of a Lower Lip Lesion: A New Case and Review of the Literature

Introduction to Oral Cancer

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