Verruciform xanthoma accompanying a cystic growth: A case report

Hara, Mariko; Kato, Yoichi; Kaku, Yo; Tsujioka, Kaoru

doi:10.1111/cup.13629

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…We found that the overwhelming majority of VXs (92%) occur in males, which is close to the proportion documented (85%) by Stiff et al Our experience suggests that in terms of sites, published case reports have somewhat over-represented (although not statistically significantly; P > 0.3) the less prevalent penile (8% versus 16%) and vulvar cases (8% versus 14%), compared to the most common site of the scrotum. While cases with inverted, endophytic or cystic features have been described, 3,7,[17][18][19] all those we encountered were polypoid and exophytic.…”

Section: Discussionmentioning

confidence: 88%

Genital verruciform xanthoma: lessons from a contemporary multi‐institutional series

Wang¹,

Mochel²,

Randall

et al. 2020

Histopathology

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Aims: Verruciform xanthoma (VX) is an uncommon lesion, seen in the oral mucosa and rarely occurring at cutaneous genital sites. Reports of exceptional VX presentations dominate the literature; herein, we assess the clinical and histological features of a cohort of routine, consecutive cases. Methods and results: Clinicopathological features of genital VXs from four academic centres were reviewed. A cohort of 25 lesions from 24 patients (22 male, two female; median age = 62 years), occurred on the scrotum (84%), penis (8%) and perineum/ vulva (8%). VX was never suspected clinically; considerations ranged from fibroepithelial polyps to squamous cell carcinoma. Classic diagnostic criteria were present at least focally in each lesion, including verrucous architecture, prominent wedge-shaped parakeratosis extending between exophytic epidermal projections and neutrophils in the stratum corneum. Xanthomatous cells were present in all cases, but scattered to rare in 24%. Conclusions: Consecutive genital VXs reliably exhibited classic histopathological features, although the essential finding of xanthomatous cells may be scarce. Our comparison to meta-analyses of published cases found relatively fewer penile and vulvar examples. Additionally, the median age was older than in published series, which have emphasised syndromic associations.

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Section: Discussionmentioning

confidence: 88%

Genital verruciform xanthoma: lessons from a contemporary multi‐institutional series

Wang¹,

Mochel²,

Randall

et al. 2020

Histopathology

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“…In addition to the differential diagnosis, VV has several variants [Figure 2]. Myrmecia, a cutaneous wart associated with HPV 1, usually seen in the skin of hands and feet (palmoplantar), has many histological features similar to VV; however, the presence of red cytoplasmic inclusion bodies helps to distinguish Myrmecia [37] . Condyloma Acuminatum, which is genital warts, histologically showed koilocytosis and papillomatosis [38] ; however, the papillomatosis in Condyloma Acuminatum is more rounded rather than spiked papillomatosis seen in VV [39] .…”

Section: Discussionmentioning

confidence: 99%

Histological differential diagnosis of verruca vulgaris: A systematic review

Alaziz¹,

Najim²

2021

Int. J. Clin. Diagn. Pathol.

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The diagnosis of Verruca Vulgaris is usually clinically, but, in certain situations, confirmation of the diagnosis with biopsy is needed. Several dermatological conditions share microscopic features with Verruca Vulgaris; however, the combination of history, dermatological examination, and histological description would confirm the diagnosis. The purpose of this study is to describe pathological conditions that share histological characteristics with verruca Vulgaris. A systematic review of the literature was used in this study. The histological differential diagnosis of verruca Vulgaris was divided into two categories. First, dermatological conditions that characterized by the presence of vacuolated cells; these conditions are Bowen's Disease and Epidermodysplasia Verruciformis. Second, dermatological conditions that show papillomatosis which includes Verrucous Epidermal Nevus, Hyperkeratotic Seborrheic keratosis, and Acanthosis Nigricans Verruciform xanthoma, Confluent and reticulated papillomatosis.

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“…Despite these limitations, this research has revealed Facebook groups as a relevant source for non-mediated debate and support in the context of mastocytosis. 8 Health benefits such as Syphilis is a sexually transmitted disease caused by Treponema pallidum . 1 In China, serofast is defined as persistently low-level positive RPR titres (≤1:8) after 12 months of follow-up in early syphilis, and serological cure is defined as a negative RPR titre.…”

mentioning

confidence: 99%

Understanding the role of social media to support patients with mastocytosis: Content analysis of Facebook communities

et al. 2020

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Verruciform xanthoma are clinically isolated lesions with a low incidence rate of concomitant hyperlipidaemia, but has been described to be associated with other conditions incuding congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD), recessive dystrophic epidermolysis bullosa, keratitis-ichthyosis-deafness syndrome, epidermal naevus syndrome or human immunodeficiency virus infection. We found only three cases with concomitant skin diseases without an inheritance syndrome. One of these patients was a 44-year-old healthy man with a lesion occurring in an epidermal cyst. There are a few published reports of crateriform verruciform xanthoma or cystic verruciform xanthoma. 8,9 A second patient, a 35-year-old healthy man, had an erythematous papule on the scrotum since childhood. He also complained of fissures on the either side of the scrotum. Histopathology showed marked acanthosis with extensive acantholysis, neutrophilic exocytosis, foamy histiocytes in the papillary dermis and mononuclear cell and neutrophils in the dermis, which is compatible with Hailey-Hailey disease. The third patient, an 82-year-old male had a condyloma accuminatum, though the HPV DNA test was not performed. This study's limitation is that all the cases were from a tertiary hospital and lacked a direct molecular-biologybased analysis. However, elderly Taiwanese men appear to have a higher risk of genital predominance of verruciform xanthoma, and the role of androgen and androgen receptor may be crucial.

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Verruciform xanthoma accompanying a cystic growth: A case report

Cited by 5 publications

References 11 publications

Genital verruciform xanthoma: lessons from a contemporary multi‐institutional series

Genital verruciform xanthoma: lessons from a contemporary multi‐institutional series

Histological differential diagnosis of verruca vulgaris: A systematic review

Understanding the role of social media to support patients with mastocytosis: Content analysis of Facebook communities

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