Vernonanthura polyanthes leaves aqueous extract enhances doxorubicin genotoxicity in somatic cells of Drosophila melanogaster and presents no antifungal activity against Candida spp.

Guerra-Santos, I. J.; Rocha, Jamira Dias; Vale, Camila Regina do; Sousa, Wendel Cruvinel de; Teles, Aristônio Magalhães; Chen-Chen, Lee; Carvalho, Salvador de; Bailão, Elisa Flávia Luiz Cardoso

doi:10.1590/1519-6984.04615

Cited by 9 publications

(5 citation statements)

References 36 publications

(50 reference statements)

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“…A previous study using Drosophila as a model to evaluate the toxic potential of V. polyanthes leaves aqueous extract showed no toxic, genotoxic, and antigenotoxic activity in the experimental conditions tested using the wing somatic mutation and recombination test SMART/wing (Guerra-Santos et al, 2016). Different from that, at the present work we identified a toxic and cytotoxic activity of V. polyanthes.…”

Section: Discussioncontrasting

confidence: 77%

“…In addition to those phytochemical screenings, previous characterization also have been shown that different V. polyanthes leaves extracts present compounds such as: flavones chrysoeriol-7-O-glycuronyl, acacetin-flavones 7-O-glycuronyl, sesquiterpenes, triterpenes, lactones piptocarphin A and piptocarphin B, glaucolide A, chlorogenic acids, coumarins, glycosides, steroids, saponin glycosides, and alkaloids (Gallon et al, 2018;Martucci et al, 2014;Igual at al., 2013;Souza et al, 2008). Despite this variety of metabolites, some studies pointed that flavonoids and terpenoids are the main compounds present in V. polyanthes extracts (Barbastefano et al, 2007;Bohlmann et al, 1981).…”

Section: Discussionmentioning

confidence: 97%

“…After a rest of 20 min, the solution was filtered using the Millipore membrane filter (0.45 μm pore size) and briefly used. The V. polyanthes leaves aqueous extract concentration commonly used in popular medicine is 20 mg/ml (ANVISA, 2011, Guerra-Santos et al, 2016. Then, it was tested five different concentrations in A. salina assay (5, 10, 20, 40, and 80 mg/ml) and three different concentrations in A. cepa assay (10, 20, and 40 mg/ml).…”

Section: Plant Collection and Preparation Of Aqueous Extractmentioning

confidence: 99%

“…In relation to the toxicity, previous study identified that the V. polyanthes aqueous extract showed no toxic, genotoxic, and antigenotoxic activity in the experimental conditions tested using the wing somatic mutation and recombination test SMART/wing (Guerra-Santos et al, 2016). On the other hand, other study demonstrated that the V. polyanthes leaves ethanolic extract was toxic to mice with LD 50 of 2.78 g/kg (Temponi et al, 2012).…”

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Cytotoxic effect of Vernonanthura polyanthes leaves aqueous extracts

et al. 2021

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Vernonanthura polyanthes, popularly known as assa-peixe, is a medicinal plant that has been widely used by Brazilian Cerrado population for treatment of diseases without a detailed evaluation of their effectiveness, toxicity, and proper dosage. Thus, more studies investigating the safety of V. polyanthes aqueous extract before the use are needed. The purpose of this study was to evaluate the toxicity, cytotoxicity and genotoxicity of V. polyanthes leaves aqueous extract using the Artemia salina and Allium cepa assays. For the A. salina assay, three groups of 10 larvae were exposed to V. polyanthes leaves aqueous extract at the concentrations of 5, 10, 20, 40, and 80 mg/ml. For the A. cepa assay, 5 onion bulbs were exposed to V. polyanthes leaves aqueous extract at 10, 20, and 40 mg/ml, and then submitted to macroscopic and microscopic analysis. As result it was identified a toxicity and cytotoxicity of V. polyanthes dependent on the extract concentration. The A. salina assay suggests that the concentration of 24 mg/ml of the V. polyanthes extract is able to kill 50% of naupllis; while the A. cepa assay suggests that V. polyanthes leaves aqueous extract is toxic at concentrations higher than 20 mg/ml; however the cytotoxic effect in A. cepa root cells was observed at 40 mg/ml of the extract. It is important to say that the V. polyanthes leaves aqueous extract concentration commonly used in popular medicine is 20 mg/ml. Thus, the popular concentration used is very close to toxicity limit in A. salina model (24 mg/ml) and is the concentration which showed toxic effect in A. cepa root cells (20 mg/ml). No genotoxic activity of V. polyantes leaves aqueous extract was observed in the conditions used in this study. Because of the antiproliferative action and no genotoxic activity, V. polyanthes leaves aqueous extract may present compounds with potential use for human medicine. However more detailed studies need to be performed to confirm this potential.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 97%

Section: Plant Collection and Preparation Of Aqueous Extractmentioning

confidence: 99%

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Cytotoxic effect of Vernonanthura polyanthes leaves aqueous extracts

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“…V. polyanthes is used therapeutically as an infusion to treat infections of the respiratory tract, muscle pain, kidney treatments, wounds, sprains, bruises, dislocations, hemorrhoids and uterus infections [18], [20], [23]. In addition, there are in vitro and in vivo tests that demonstrate its diuretic, antihypertensive, anti-hemorrhagic, sedative, abortive, anthelmintic, antiulcerogenic, antirheumatic, healing, anti-inflammatory, antinociceptive, antibacterial, antifungal, leishmanicidal and anti-tumor actions [18], [21], [23], [24], [25], [26], [27], [28], [29].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antioxidant, Anti-Cytotoxic and Anticancer Effects of Galinsoga Parviflora and Vernonia Polyanthes (Asteraceae) Extracts

Feleti

Aleluia

Gervásio

et al. 2020

Int. J. Res. Granthaalayah

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The study was designed to investigate the chemical composition and the biological effects of G. parviflora and V. polyanthes ethanolic extracts in vitro. Total content of phenols, flavonoids and tannins was quantified by spectrophotometry; chemical characterization was permed by mass spectrometry (ESI (-) FT-ICR MS and APCI (+) FT-ICR MS analysis). Antioxidant activities were determined by FRAP and Fe2+ chelating methods. Extracts cytotoxicity was evaluated in human lymphocytes, sarcoma-180 (S-180) and human gastric adenocarcinoma (AGS) cells, by MTT assay. V. polyanthes presented higher total content of tannins and G. parviflora presented higher amount of phenols and flavonoids. Chemical characterization showed the presence of flavonoids, phenolic acids and sesquiterpene lactones in V. polyanthes extract, and steroids, phenolic acids and fatty acids (Poly Unsaturated Fatty Acids - PUFA) in G. parviflora extract. V. polyanthes extract stood out in the Fe2+ chelation test. G. parviflora extract did not present outstanding antioxidant results in the tested protocols. Both species showed a tendency to promote cytotoxicity in human lymphocyte cells. Regarding the antiproliferative effect, both species were able to reduce S-180 cell viability and G. parviflora extract showed high antiproliferative potential in the assay with AGS cells. These findings reinforce the medicinal use of these plants, as well as suggest their potential use for the development of new drugs and for the treatment of cancers.

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The impact of the invasive alien plant Vernonanthura polyanthes on conservation and livelihoods in the Chimanimani uplands of Zimbabwe

Kachena,

Shackleton

2024

Biol Invasions

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Biological invasions can have major social-ecological consequences for rural communities across the world. However, the dimensions (characteristics, infestation and socio-ecological impacts) of emerging invasive alien plants are often less known and urgent information is needed to guide policy and management. In light of this, this paper assesses the social-ecological impacts of Vernonanthura polyanthes, an emerging invasive alien plant found in a Zimbabwean upland landscape which supports conservation and livelihoods. The paper employs qualitative methods—community mapping, time series analysis, and key informant interviews—involving individuals from diverse socio-economic backgrounds, to examine the socio-ecological and economic implications of V. polyanthes and its management in Chimanimani, Zimbabwe. We found that there are nuanced perspectives regarding this invasive alien plant among different socio-economic groups in the region who have different experiences of living with V. polyanthes. Some are embracing it for apiculture, firewood, and ethnomedicine while, on the other hand, some see the tree as negatively affecting key livelihoods (crop farming, pastoralism, and tourism) that are common in the region. Local people also identified that V. polyanthes is associated with ecological impacts that include loss of biodiversity, promoting pests, and negatively affecting watersheds and associated water sources. These mixed experiences concerning the plant are leading to different management practices, in turn inducing some conflicts among various actors. Based on our findings, we suggest more should be done to better manage this invasive alien plant in the region before negative impacts become too great, particularly in protected areas.

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Vernonanthura polyanthes leaves aqueous extract enhances doxorubicin genotoxicity in somatic cells of Drosophila melanogaster and presents no antifungal activity against Candida spp.

Cited by 9 publications

References 36 publications

Cytotoxic effect of Vernonanthura polyanthes leaves aqueous extracts

Cytotoxic effect of Vernonanthura polyanthes leaves aqueous extracts

Phytochemical Screening, Antioxidant, Anti-Cytotoxic and Anticancer Effects of Galinsoga Parviflora and Vernonia Polyanthes (Asteraceae) Extracts

The impact of the invasive alien plant Vernonanthura polyanthes on conservation and livelihoods in the Chimanimani uplands of Zimbabwe

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