Phytochemical Screening, Antioxidant, Anti-Cytotoxic and Anticancer Effects of Galinsoga Parviflora and Vernonia Polyanthes (Asteraceae) Extracts

Feleti, Sula M. V.; Aleluia, Renê Lemos; Gervásio, Suiany Vitorino; Dutra, Jean Carlos Vencioneck; Oliveira, José Roberto de; Gonçalves, Rita de Rita de Cássia R.; Jamal, Cláudia Masrouah; Küster, Ricardo Machado; Brasileiro, Beatriz Gonçalves; Batitucci, Maria do Carmo Pimentel

doi:10.29121/granthaalayah.v8.i10.2020.1782

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Many authors attribute the antioxidant activity of plant extracts to the levels of phenolic compounds [11,12,[29][30][31][32]. Regarding the DPPH assay, the ethanol fraction from the study by Oliveira et al [27] showed better antioxidant power than that observed in our study using the crude ethanol extract of L. alba, reaching 30.33 to 99.96% of radical inhibition.…”

Section: Discussionmentioning

confidence: 44%

In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba

Dutra¹,

Kohls²,

Pereira³

et al. 2022

JPP

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Lippia alba is a herb widely distributed in Latin America used in the traditional medicine. Considering that medicinal plants present anticancer action, the aim of the work was to verify the in vitro antioxidant, cytotoxic, anti-cytotoxic and anticancer effects of L. alba extract, correlating the results with phytochemical content. Phytochemicals were evaluated by spectrophotometry; antioxidant activity was evaluated by DPPH, ABTS and Fe 2+ chelating activity. In vitro cytotoxicity and anti-cytotoxicity were evaluated in human lymphocytes and anticancer action was evaluated in sarcoma-180 cells. L. alba extract presents good antioxidant, antiproliferative and anti-cytotoxic effects. Total flavonoid content was correlated to the antiproliferative effect; total tannin content was correlates to ABTS antioxidant activity and to health cells maintenance. Tannins were also correlated to the prevention of cisplatin-induced damage. Our finds support the use of L. alba as a source of natural antioxidants and as a potent anticancer and anti-cytotoxic agent, reinforcing the use of natural products for health promotion.

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Section: Discussionmentioning

confidence: 44%

In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba

Dutra¹,

Kohls²,

Pereira³

et al. 2022

JPP

View full text Add to dashboard Cite

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Phytochemical Composition and Protective Effect of Vernonanthura polyanthes Leaf against In Vivo Doxorubicin-Mediated Toxicity

et al. 2022

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Vernonanthura polyanthes (Spreng.) A.J. Vega & Dematt. (syn.: Vernonia polyanthes Less) is popularly known as “assa-peixe” and its leaves are used in folk medicine mainly to treat respiratory diseases. In this study, we evaluated the cytogenotoxic and anticytogenotoxic potential of the V. polyanthes leaf aqueous extract (VpLAE) and its n-butanol fraction (n-BF) in the presence or absence of doxorubicin (DXR) (pre-, co-, and post-treatments) on a murine model for 24 h or 120 h. The micronucleus test (MN) and the comet assay were used to assess the cytogenotoxic and anticytogenotoxic potential of VpLAE and n-BF (250, 500, and 1000 mg/kg) administered via gavage to Swiss Webster mice. The chemical profiles of VpLAE and n-BF were assessed by liquid chromatography coupled to mass spectrometry, and their metabolites were putatively identified. Lastly, the possible biological activities related to the (anti) cytogenotoxicity of the compounds were predicted using the PASS online webserver. The in vivo results showed that different doses of VpLAE and n-BF did not present cytotoxic activity; however, the MN test revealed a slight mutagenic activity for the 24 h treatments. Moderate genotoxic effects were demonstrated for all treatments in the comet assay. Regarding anticytotoxicity and antimutagenicity, VpLAE and n-BF presented a high cytoprotective potential against DXR toxic effects. In the co-treatment, VpLAE reduced the DXR genotoxicity by ~27%, and n-BF did not demonstrate antigenotoxic potential. In contrast, an antigenotoxic effect was observed for both VpLAE and n-BF in the pre- and post-treatments, reducing DXR genotoxicity by ~41% and ~47%, respectively. Chemical analysis of VpLAE and n-BF showed the presence of eight phenolic compounds, including seven chlorogenic acids and a flavonoid. The PASS online tool predicted antimutagenic, anticancer, antineoplastic, chemoprotective, antioxidant, and radical scavenging activities for all constituents identified in VpLAE and n-BF. V. polyanthes leaves presented a protective effect against DXR cytogenotoxicity. In general, VpLAE and n-BF showed a greater antigenotoxic potential in the pre- and post-treatments. The metabolites putatively identified in VpLAE and n-BF exhibited antioxidant and chemoprotective potential according to computational prediction analysis. Altogether, our results highlight the potential application of V. polyanthes to protect against toxic manifestations induced by DXR.

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Phytochemical Screening, Antioxidant, Anti-Cytotoxic and Anticancer Effects of Galinsoga Parviflora and Vernonia Polyanthes (Asteraceae) Extracts

Cited by 2 publications

References 57 publications

In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba

In Vitro Antioxidant, Anticancer and Anti-cytotoxic Activity of Lippia alba

Phytochemical Composition and Protective Effect of Vernonanthura polyanthes Leaf against In Vivo Doxorubicin-Mediated Toxicity

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