Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens

Silverman, Mark K.; Golomb, Frederick M.; Kopf, Alfred W.; Grin-Jorgensen, Caron; Vossaert, Katrien; Doyle, Joyce; Levenstein, Marcia

doi:10.1016/0190-9622(92)70173-d

Cited by 68 publications

(61 citation statements)

References 14 publications

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“…Many surgeons have observed the problem of margin shrinkage at other sites. In a study on cutaneous malignant melanoma, Silverman et al [9] reported 15%-25% shrinkage in the margins depending on the patient age. In studies on rectal cancer Goldenstein et al [10] and Sondenna et al [11] noticed 50% or more shrinkage of margins, most of these occurring immediately after resection.…”

Section: Discussionmentioning

confidence: 97%

“…This is largely attributed to the margin shrinkage following resection and less commonly to the presence of microscopic neoplastic foci beyond the palpable and visual margins [8]. The problem of margin shrinkage has been dealt with at other sites, but has not been analyzed and quantified in oral cavity cancers [9][10][11][12]. The only study addressing margin shrinkage in oral cavity was an animal experiment on dogs [8].…”

Section: Introductionmentioning

confidence: 97%

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Post-resection mucosal margin shrinkage in oral cancer: Quantification and significance

2005

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Post-resection mucosal margin shrinkage in oral cancer: Quantification and significance

2005

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“…Ex vivo specimen measurement may result in underestimation of lesion diameter by as much as 20%. 22,23 The rigor of our study design allows much greater insight into the relationship between lesion diameter and diagnosis than any previous study by using accurate lesion measurements rather than the rough estimates not uncommon in dermatologic practice. The goal of this study was to determine if a diameter measurement of greater than 6 mm was still a useful guideline in the diagnosis of melanoma.…”

Section: Commentmentioning

confidence: 99%

Utility of Lesion Diameter in the Clinical Diagnosis of Cutaneous Melanoma

Abbasi¹,

Yancovitz²,

Gutkowicz–Krusin³

et al. 2008

Arch Dermatol

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“…Thus, in a study by Silverman et al [27] on 199 cutaneous malignant melanoma reported of a shrinkage of a 15 to 25% on margins of surgical specimens depending on the patient's age. Likewise, Weese et al [28] observed in ten patients who underwent colonic resection that resected rectal margin could shrink up to 50% or more after processing histologic of surgical piece.…”

Section: Discussionmentioning

confidence: 99%

The tissue shrinkage phenomenon on surgical margins in oral and oropharyngeal squamous cell carcinoma

González-Ballester¹

2016

PAR

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Aim: One of the most important factors associated with recurrence rate and overall survival is the status of surgical margin of resection free of disease. However, sometimes, the margins measured intra-operatively at the time of surgery differ of those measured by the pathologist in the histopathologic analysis. Faced with this dilemma, a literature review of the best available evidence was conducted in an attempt to determine how the phenomenon of tissue shrinkage may influence on the surgical margin of resection in patients undergoing oral and oropharyngeal squamous cell carcinoma (SCC). Methods: An electronic and manual search was conducted by one reviewer. A combination of controlled Medical Subjects Headings and keywords were used as search strategy. Inclusion and exclusion criteria were established. Results: Finally, after an exhaustive selection process, four articles fulfilled the inclusion criteria and were analyzed. All articles reported a decrease of surgical margin after resection. The tumor site and tumor stage seem to influence in degree of margin shrinkage. Conclusion: Tissue shrinkage on surgical margins of resection in oral SCC is a tangible phenomenon. There is a significant discrepancy between margins measured intraoperatively previous to resection and margins measured by pathologist after histologic processing. The highest percentage of retraction occurs at the time of resection. Margin shrinkage based on tumor site and tumor stage should be considered by any oncologic surgeon to ensure adequate margins of resection cleared of tumor.

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Verification of a formula for determination of preexcision surgical margins from fixed-tissue melanoma specimens

Cited by 68 publications

References 14 publications

Post-resection mucosal margin shrinkage in oral cancer: Quantification and significance

Post-resection mucosal margin shrinkage in oral cancer: Quantification and significance

Utility of Lesion Diameter in the Clinical Diagnosis of Cutaneous Melanoma

The tissue shrinkage phenomenon on surgical margins in oral and oropharyngeal squamous cell carcinoma

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