Vergleichende Studie zur Therapie des Trockenen Auges bedingt durch Lipidphasenstörungen mit lipidhaltigen Tränenpräparaten

Dausch, D; Lee, S.; Dausch, Sabine; Kim, J. C.; Schwert, G.; Michelson, W.

doi:10.1055/s-2006-927266

Cited by 45 publications

(21 citation statements)

References 50 publications

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“…Our results are in good agreement with the results of Korb and others [11][12][13][14][15][16][17] that artificial tears containing phosphatidylcholine and other phospholipids strongly increase the thickness and the non-invasive break-up time of TF in vivo.…”

Section: Discussionsupporting

confidence: 92%

“…At present they are used as compounds of artificial tears (Tears Again, Soothe, Refresh Dry Eye Therapy, FreshKote, Refresh Endura) targeted to replenish the TF lipid layer of patients with Dry Eye Syndrome. Although the number of lipid-containing artificial tears on the market still remains relatively limited, in vivo studies demonstrated that formulations containing phospholipids and other PLs significantly increase the non-invasive break-up time of TF in laboratory animals and humans [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Georgiev

Kutsarova

Jordanova

et al. 2010

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tThe surface interactions of Meibomian gland secretion (MGS) with polar lipid (PL), Egg Sphingomyelin (SM) or Dipalmitoylphosphatidylcholine (DPPC), are studied in mixed pseudo-binary films formed at the air/water interface of Langmuir surface balance. The behavior of the mixed films during slow quasi-equilibrium compression and during fast dynamic compression-decompression is registered by measurements of surface pressure and surface potential, and by monitoring film morphology with Brewster Angle Microscopy (BAM). Quasi-equilibrium compression isotherms are used to calculate the excess Gibbs and Helmholtz energy of mixing between MGS and PLs and thus to evaluate the interactions between the lipid compounds at the interface. The effects of PLs on the mixed film's elastic moduli of area compressibility, morphology and capability to attain high surface pressures are also examined.PLs interact with MGS with different strength and in different manner: MGS-SM interaction is weak and might lead to interfacial disaggregation of the thick meibium domains when SM is in excess, while MGS-DPPC interaction is strong and results in the formation of thick lipid aggregates. Both PLs increase the mixed films reciprocal compressibility and capability to achieve higher surface pressures. The results demonstrate that in vitro studies of the surface interactions between MGS and PLs might be beneficial in the selection of PLs for artificial tear formulations and for examination on molecular scale of the possible role of PLs at the ocular surface.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Georgiev

Kutsarova

Jordanova

et al. 2010

Colloids and Surfaces B: Biointerfaces

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“…Similar to the findings by Böhm et al [6], the safety and tolerability of the treatment investigated here can be assessed as good, since no treatment-related adverse events or serious adverse events occurred. These results are consistent with those from previous studies evaluating the effect of LS for dry eye [8, 10] and with findings from studies assessing liposomal nasal spray [13, 15]. …”

Section: Discussionsupporting

confidence: 92%

“…The results of the patients’ perception of the treatment are comparable to those reported in studies exploring the application of liposomes for dry eye and in studies assessing liposomal nasal spray for treating seasonal allergic rhinitis. Subjective improvement of symptoms was observed in these studies [6-8, 11, 14]. For example, according to Lee et al [11], 72% of patients indicated noticeable relief of dry eye symptoms after the application of LS.…”

Section: Discussionmentioning

confidence: 97%

Liposomal Eye Spray Is as Effective as Antihistamine Eye Drops in Patients with Allergic Rhinoconjunctivitis Induced by Conjunctival Provocation Testing

Grzella

Schleicher

Shah‐Hosseini

et al. 2019

Int Arch Allergy Immunol

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Background: Liposomal eye spray (LS) has been introduced for the treatment of dry eye. Whether LS can also relieve symptoms due to allergic rhinoconjunctivitis (ARC) has not yet been sufficiently investigated. Objectives: The aim of this study was to assess the onset of action, the reduction of allergy symptoms, and the safety of LS – a nonpharmacological treatment option – compared with those of antihistamine eye drops (AD). Methods: In this open, prospective, controlled, monocenter noninterventional study, adults with ARC received either LS or AD for the relief of eye irritation after a positive conjunctival provocation test (CPT). All patients completed a questionnaire before and after the CPT. Eye irritation was rated on a visual analogue scale (VAS) at 6 time points. Conjunctival redness was analyzed using objective digital analysis based on images taken during the study visit. Results: Data were collected from 40 patients (20 per group). In both groups, 80% of patients perceived an onset of action within 0–2 min after application of LS or AD following the CPT. Relief of eye irritation (as determined by VAS) increased throughout the visit for both groups. In the digital analysis, the mean proportion of redness of the eye decreased from 10.3 to 7.0% for LS and from 10.4 to 6.5% for AD, with the largest difference observed 10 min after application (LS: 8.9%; AD: 6.0%; p = 0.094). Conclusions: LS is a nonpharmacological treatment option for ARC, showing no significant difference or relevant numerical inferiority to AD in any parameter studied. It was generally safe and well tolerated.

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Section: Introductionmentioning

confidence: 99%

In VitroApplication of Langmuir Monolayer Model to StudyIn VivoBiological Systems

Tsanova

Georgiev

Lalchev

2012

Biotechnology & Biotechnological Equipment

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Vergleichende Studie zur Therapie des Trockenen Auges bedingt durch Lipidphasenstörungen mit lipidhaltigen Tränenpräparaten

Abstract: The treatment with phospholipids liposomes shows statistically significant clinical advantages and proves to be favourably and explicitly superior compared to the conventional standard treatment all in all.

Cited by 45 publications

References 50 publications

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Liposomal Eye Spray Is as Effective as Antihistamine Eye Drops in Patients with Allergic Rhinoconjunctivitis Induced by Conjunctival Provocation Testing

In VitroApplication of Langmuir Monolayer Model to StudyIn VivoBiological Systems

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