Vergleichende biochemische Untersuchungen bei organischen Parkinsonsyndromen und medikamentösem Parkinsonoid

Bruck, H; Gerstenbrand, F; Gnad, H. D.; Gründig, E; P, Prosenz

doi:10.1159/000127287

Cited by 9 publications

(2 citation statements)

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“…This may be explained in the light of previous work (1,2), in which a decrease observed in glutamic acid was compensated by an augmentation of glycine, serine and related amino acids. There is a correlation between glucose utilisation and glutamic acid level in the CNS; thus, the disturbance of glucose metabolism was reported to produce a decrease in the glutamic acid level in the CNS (12).…”

Section: Discussionmentioning

confidence: 61%

“…Parkinson's disease as well as human drug induced Parkinsonism have been reported to exhibit comparable changes in the spectrum of amino acids in cerebrospinal fluid (1). The recorded changes of free amino acids in brains of rats were comparable to those of human CSF, in those cases where the experimental tratment lead to akinesis, rigor and tremor (2).…”

Section: Introductionmentioning

confidence: 83%

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Incorporation of [U- 14 C]Glucose into Metabolites of Brain, Liver and Blood of Rats Pretreated with Reserpine or Phenothiazines

Raheem¹,

Gründig²,

Salvenmoser³

et al. 1979

Clinical Chemistry and Laboratory Medicine

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Summary:Parkinsonism was induced in rats by using phenothiazines (Butyrylperazin and Thioproperazin), (P-group), or reserpine, (R-group). [U-14 C)D-glucose was administered when the symptoms of Parkinsonism had become fully developed. Concentrations and radioactivities of different metabolites were studied in brain, liver and blood serum. 3. Both treatments caused a fall in the amino acid concentration of the blood serum. A rise in the specific radioactivity of blood amino acids was observed in the P^group, while a decrease in specific radioactivity was observed in the R-group. A hyperglycemia was induced in the R-group with reduced specific radioactivity of glucose in both P-and R-groups. A reduction in lipid concentration of blood serum was achieved with an increased specific radioactivity in P-group and decreased radioactivity in R-group.4. The changes in amino acids common to both treatments are also observed in human Parkinsonism. Der Einbau von [i/-14

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 83%