Incorporation of [U- 14 C]Glucose into Metabolites of Brain, Liver and Blood of Rats Pretreated with Reserpine or Phenothiazines

Abstract

Summary:Parkinsonism was induced in rats by using phenothiazines (Butyrylperazin and Thioproperazin), (P-group), or reserpine, (R-group). [U-14 C)D-glucose was administered when the symptoms of Parkinsonism had become fully developed. Concentrations and radioactivities of different metabolites were studied in brain, liver and blood serum. 3. Both treatments caused a fall in the amino acid concentration of the blood serum. A rise in the specific radioactivity of blood amino acids was observed in the P^group, while a decrease in specific radioactivity was observed in the R-group. A hyperglycemia was induced in the R-group with reduced specific radioactivity of glucose in both P-and R-groups. A reduction in lipid concentration of blood serum was achieved with an increased specific radioactivity in P-group and decreased radioactivity in R-group.4. The changes in amino acids common to both treatments are also observed in human Parkinsonism. Der Einbau von [i/-14