Vergleich von kontrastmittelunterstützter Low-Mechanical-Index(Low-MI)-Sonographie und nativer B-Mode-Sonographie bei der Differenzierung von Synovitis und Gelenkerguss bei Patienten mit rheumatoider Arthritis

Kleffel, Timm; Demharter, J; Wohlgemuth, WA; Schalm, J.; Bohndorf, Klaus; Kirchhof, Klaus

doi:10.1055/s-2005-858194

Cited by 16 publications

(3 citation statements)

References 6 publications

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“…Although color Doppler ultrasound (CDUS) imaging allows the detection of vascularity, 15–19 its ability to detect slow flow and flow in small vessels is limited. Compared with unenhanced power Doppler ultrasound, contrast-enhanced ultrasound (CEUS) has demonstrated a better ability to characterize the vascularization in the inflamed synovium, 20 because the contrast agent 21 not only improves the detection of the color signal and the extension of vascularization, 22,23 but also allows the quantitative assessment of inflammation. 24…”

Section: Introductionmentioning

confidence: 99%

Value of contrast-enhanced ultrasound for detection of synovial vascularity in experimental rheumatoid arthritis: an exploratory study

et al. 2019

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ObjectiveThis study aimed to examine the associations between contrast-enhanced ultrasound (CEUS) imaging and synovial hypervascularity and synovitis score in a rabbit model of antigen-induced arthritis (AIA), compared with power Doppler ultrasound (PDUS).MethodsWe investigated 50 knee joints in 25 AIA rabbits (AIA group), and 10 knee joints in five sham-injected rabbits (control group). PDUS and CEUS images were evaluated at the 8th week. Ultrasound-guided synovial biopsies were targeted in the area with hypervascularity, and synovial microvessel density (MVD) was evaluated by immunohistochemical staining of CD31.ResultsThe PDUS score was significantly higher in the AIA group (2.61 ± 0.78) compared with the control group (0.50 ± 0.53). CEUS in the AIA group revealed a fast-in/slow-out pattern of contrast enhancement. MVD revealed by CD31+ vessel count and the synovitis score were significantly higher in the AIA group compared with the control group. In the AIA group, CEUS findings showed a better correlation with MVD revealed by CD31+ and synovitis score than PDUS findings.ConclusionCEUS is superior to PDUS for estimating synovial hypervascularity and hyperplasia in experimental rheumatoid arthritis.

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Section: Introductionmentioning

confidence: 99%

Value of contrast-enhanced ultrasound for detection of synovial vascularity in experimental rheumatoid arthritis: an exploratory study

et al. 2019

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“…[43] Apart from synovitis, other specific histological features of inflammatory arthritis, such as bursal involvement, tendon lesions, and bone erosions, can also be detected by CEUS.…”

Section: Sonographic Findings and Histopathologic Features Of Contrasmentioning

confidence: 99%

“…And, CEUS did better than B-mode US, in differentiating synovitis and joint effusions, by demonstrating enhancement pattern of intra-articular vascularization in synovitis. [43] Another research conducted by a group of German scientists, performed CEUS, PDUS, and conventional US in the patients of RA, and evaluated the efficacy of these methods, using MRI results as the standard. A higher correlation rate of CEUS with MRI scoring was demonstrated in this study, which indicated a superior sensitivity of CEUS in detecting synovitis.…”

Section: Comparisons With Other Imaging Techniquesmentioning

confidence: 99%

Role of Contrast-enhanced Ultrasound in the Evaluation of Inflammatory Arthritis

Zhao

Jiang

et al. 2017

Chinese Medical Journal

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Objective:Contrast-enhanced ultrasound (CEUS) is a well-established imaging modality which has been put into clinical use in recent years with the development of second-generation contrast agent and imaging devices, and its applications in the assessment of inflammatory arthritis, such as rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, have provoked abundant discussion and researches among radiologists and rheumatologists. To summarize the achievements of clinical studies on CEUS in the application of arthritis, and to keep up with the latest progresses of the imaging technique, we reviewed the literature in recent years, hoping to establish the role of CEUS in joint diseases.Data Sources:PubMed and EMBASE.Study Selection:We searched the database with the conditions “contrast-enhanced ultrasound AND arthritis” with the time limitation of recent 10 years. Clinical studies applying CEUS in inflammatory arthritis and review articles about development of CEUS in joint diseases in English were selected.Results:As it is proved by most studies in recent years, by delineating microvasculature within the inflamed joints, CEUS can indicate early arthritis with high sensitivity and specificity. Moreover, the imaging of CEUS has been proved to be consistent with histopathological changes of inflammatory arthritis. Quantitative analysis of CEUS permits further evaluation of disease activity. CEUS also plays a significant role in the therapeutic monitoring of the disease, which has been backed up by a number of studies.Conclusions:CEUS may be a new choice for the rheumatologists to evaluate inflammatory arthritis, because of its low price, ability to provide dynamic pictures, and high sensitivity to angiogenesis. It can also be applied in disease classification and therapeutic monitoring. More studies about CEUS need to be done to set up the diagnostic standards.

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Intraoperative Contrast‐Enhanced Ultrasound Imaging of Femoral Head Perfusion in Developmental Dysplasia of the Hip: A Feasibility Study

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Chauvin²,

Ntoulia

et al. 2019

J of Ultrasound Medicine

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Objectives Developmental dysplasia of the hip (DDH) is one of the most common developmental deformities of the lower extremity. Although many children are successfully treated with a brace or harness, some require intraoperative closed or open reduction and spica casting. Surgical reduction is largely successful to relocate the hip; however, iatrogenic avascular necrosis is a major source of morbidity. Recent research showed that postoperative gadolinium‐enhanced magnetic resonance imaging (MRI) can depict hip perfusion, which may predict a future incidence of avascular necrosis. As contrast‐enhanced ultrasound (CEUS) assesses blood flow in real time, it may be an effective intraoperative alternative to evaluate femoral head perfusion. Here we describe our initial experience regarding the feasibility of intraoperative CEUS of the hip for the assessment of femoral head perfusion before and after DDH reduction. Methods This single‐institution retrospective Institutional Review Board–approved study with a waiver of informed consent evaluated intraoperative hip CEUS in children with DDH compared to postoperative contrast‐enhanced MRI. Pediatric radiologists, blinded to prior imaging findings and outcomes, reviewed both CEUS and MRI examinations separately and some time from the initial examination both independently and in consensus. Results Seventeen patients had 20 intraoperative CEUS examinations. Twelve of 17 (70.6%) had prereduction hip CEUS, postreduction hip CEUS, and postreduction gadolinium‐enhanced MRI. Seven of 12 (58.3%) were evaluable retrospectively. All CEUS studies showed blood flow in the femoral epiphysis before and after reduction, and all MRI studies showed femoral head enhancement after reduction. The CEUS and MRI for all 7 patients also showed physeal blood flow. Conclusions Contrast‐enhanced ultrasound is a feasible intraoperative tool for assessing adequate blood flow after hip reduction surgery in DDH.

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Vergleich von kontrastmittelunterstützter Low-Mechanical-Index(Low-MI)-Sonographie und nativer B-Mode-Sonographie bei der Differenzierung von Synovitis und Gelenkerguss bei Patienten mit rheumatoider Arthritis

Abstract: Contrast-enhanced low-MI sonography is superior to non-enhanced B-Mode sonography in differentiating synovitis and joint effusion.

Cited by 16 publications

References 6 publications

Value of contrast-enhanced ultrasound for detection of synovial vascularity in experimental rheumatoid arthritis: an exploratory study

Value of contrast-enhanced ultrasound for detection of synovial vascularity in experimental rheumatoid arthritis: an exploratory study

Role of Contrast-enhanced Ultrasound in the Evaluation of Inflammatory Arthritis

Intraoperative Contrast‐Enhanced Ultrasound Imaging of Femoral Head Perfusion in Developmental Dysplasia of the Hip: A Feasibility Study

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