Verbascoside protects from LPS-induced septic cardiomyopathy via alleviating cardiac inflammation, oxidative stress and regulating mitochondrial dynamics

Zhu, Xuanfeng; Sun, Min; Guo, Hongmei; Gan, Lu; Gu, Jianhua; Zhang, Lingling; Shi, Licheng; Jia, Guanqing; Zhang, Dandan; Wang, Wenjun; Liu, Jiannan; Wang, Xia

doi:10.1016/j.ecoenv.2022.113327

Cited by 26 publications

(23 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In LPS-induced sepsis, AC greatly enhances cardiac functions by amelioration of inflammation and oxidative stress. Specifically, AC increases mitochondrial biogenesis and restores sepsis-induced mitochondrial changes, inhibiting apoptosis in cardiomyocytes [115] ( Fig. 6 , Table 1 ).…”

Section: Cardiovascular Protectionmentioning

confidence: 95%

See 1 more Smart Citation

The pharmacokinetic property and pharmacological activity of acteoside: A review

Xiao¹,

Ren²,

Wu³

2022

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Section: Cardiovascular Protectionmentioning

confidence: 95%

“… [113] H9c2 Increases mitochondrial biogenesis, inhibits apoptosis. [115] Rats Improves the lipid profiles and the organ coefficients by AMPK/mTOR signaling. [118] Anti-diabetes Caco-2 Inhibits SGLT1-mediated glucose absorption.…”

Section: Pharmacokinetic Profilesmentioning

confidence: 99%

The pharmacokinetic property and pharmacological activity of acteoside: A review

Xiao¹,

Ren²,

Wu³

2022

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

“…These results suggest that in addition to the inflammatory response, upregulation of HDAC7/ACTN4 may also be involved in some apoptosis-related pathways. A previous study also reported the involvement of apoptosis in the progression of SIC ( 90 ). Therefore, HDAC7/ACTN4 may be involved in pathways related to inflammatory response and apoptosis, thus influencing the recovery, recurrence, and progression of SIC and affecting the prognosis of patients with SIC.…”

Section: Discussionmentioning

confidence: 68%

MicroRNAs Promote the Progression of Sepsis-Induced Cardiomyopathy and Neurovascular Dysfunction Through Upregulation of NF-kappaB Signaling Pathway-Associated HDAC7/ACTN4

Luo

Guo

et al. 2022

Front. Neurol.

View full text Add to dashboard Cite

IntroductionThe objective of this study was to determine the NF-kappaB pathway, hub genes, and transcription factors (TFs) in monocytes implicated in the progression of neurovascular-related sepsis-induced cardiomyopathy (SIC) as well as potential miRNAs with regulatory functions.Methods: Sepsis-induced cardiomyopathy—and heart failure (HF)-related differentially expressed genes (DEGs) between SIC and HF groups were identified separately by differential analysis. In addition, DEGs and differentially expressed miRNAs (DEmiRNAs) in monocytes between sepsis and the HC group were identified. Then, common DEGs in SIC, HF, and monocyte groups were identified by intersection analysis. Based on the functional pathways enriched by these DEGs, genes related to the NF-kB-inducing kinase (NIK)/NF-kappaB signaling pathway were selected for further intersection analysis to obtain hub genes. These common DEGs, together with sepsis-related DEmiRNAs, were used to construct a molecular interplay network and to identify core TFs in the network.Results: A total of 153 upregulated genes and 25 downregulated genes were obtained from SIC-, HF-, and monocyte-related DEGs. Functional pathway analysis revealed that the upregulated genes were enriched in NF-κB signaling pathway. A total of eight genes associated with NF-κB signaling pathway were then further identified from the 178 DEGs. In combination with sepsis-related DEmiRNAs, HDAC7/ACTN4 was identified as a key transcriptional regulatory pair in the progression of SIC and in monocyte regulation. hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p can regulate the progression of SIC through the regulation of HDAC7/ACTN4. Finally, gene set enrichment analysis (GSEA) suggested that HDAC7/ACTN4 may be associated with apoptosis in addition to the inflammatory response.Conclusion: hsa-miR-23a-3p, hsa-miR-3175, and hsa-miR-23b-3p are involved in SIC progression by regulating NF-κB signaling signaling pathway-related HDAC7/ACTN4 in monocytes and cardiac tissue cells. These mechanisms may contribute to sepsis-induced neurovascular damage.

show abstract

“…Caffeic acid inhibits IL-1β induced inflammation responses through suppression of NF-κB and MAPK related JNK signalling pathways ( 36 ). Verbascoside could also inhibit oxidative stress and inflammation ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanism and Molecular Targets of Ejiao Siwu Decoction for Treating Primary Immune Thrombocytopenia Based on High-Performance Liquid Chromatograph, Network Pharmacology, Molecular Docking and Cytokines Validation

et al. 2022

View full text Add to dashboard Cite

We explored the mechanisms and molecular targets of Ejiao Siwu Decoction (EJSW) for treating primary immune thrombocytopenia (ITP) using network pharmacology and molecular docking. Active compounds of EJSW were identified by high-performance liquid chromatography-diode array detector (HPLC-DAD) and high-performance liquid chromatography-mass spectrometry (HPLC-MS) and their targets were obtained from HERB and SwissTargetPrediction, and ITP targets were obtained from Comparative Toxicogenomics Database (CTD) and GeneCards. STRING and Cytoscape were used for protein-protein interaction (PPI) network analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses by WebGestalt yielded a gene-pathway network, Autodock molecular docking was applied to screen targets and active compounds, and cytokines were detected using a cytometric bead array (CBA) human inflammation kit. We identified 14 compounds and 129 targets, and 1,726 ITP targets. RAC-alpha serine/threonine-protein kinase (AKT1), tumour necrosis factor (TNF), interleukin-6 (IL6), caspase-3 (CASP3) and tumour suppressor protein (TP53) were core targets (nodes and edges). Functional annotation identified cofactor binding and coenzyme binding, and 20 significantly enriched pathways. Active compounds of EJSW were successfully docked with ITP targets. Tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) were upregulated in ITP patients, vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor D (VEGF-D) were downregulated, and EJSW treatment reversed these trends. EJSW may regulate key ITP targets based on the in silico analyses, and protect vascular integrity through AGE-RAGE signalling, complement and coagulation cascades, and VEGF signalling by downregulating TNF-α, IL-1β and other inflammatory factors.

show abstract

Verbascoside protects from LPS-induced septic cardiomyopathy via alleviating cardiac inflammation, oxidative stress and regulating mitochondrial dynamics

Cited by 26 publications

References 41 publications

The pharmacokinetic property and pharmacological activity of acteoside: A review

The pharmacokinetic property and pharmacological activity of acteoside: A review

MicroRNAs Promote the Progression of Sepsis-Induced Cardiomyopathy and Neurovascular Dysfunction Through Upregulation of NF-kappaB Signaling Pathway-Associated HDAC7/ACTN4

Mechanism and Molecular Targets of Ejiao Siwu Decoction for Treating Primary Immune Thrombocytopenia Based on High-Performance Liquid Chromatograph, Network Pharmacology, Molecular Docking and Cytokines Validation

Contact Info

Product

Resources

About