The pharmacokinetic property and pharmacological activity of acteoside: A review

Xiao, Yaosheng; Ren, Qun; Wu, Longhuo

doi:10.1016/j.biopha.2022.113296

Cited by 54 publications

(40 citation statements)

References 158 publications

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“…Structurally, the caffeoyl moiety in the chemical structure of Act shows a great affinity to phospholipid membranes with negative charge; mechanically, the phenyl rings of Act can form hydrogen bonds with other residues, changing the hydrogen-bond network in the structure and combine to the target region with a low binding energy ( Xiao, Ren & Wu, 2022 ). Based on the above characteristics, Act can better pass through the cell membrane and finally exert its pharmacological effects.…”

Section: Discussionmentioning

confidence: 99%

Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway

Mao

et al. 2023

PeerJ

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Purpose Acteoside (Act), a phenylethanoid compound that was first isolated from mullein, has been widely used for the investigation of anti-inflammatory and anti-fibrotic effect. However, the mechanism of Act against unilateral ureteral obstruction (UUO)-mediated renal injury is largely unknown. Therefore, this study aimed to explore the effects of Act on UUO rats and possible mechanisms. Methods A total of 20 Sprague-Dawley (SD) rats were divided randomly into three groups (n ≥ 6): (i) sham-operated group (Sham); (ii) UUO group (UUO+Saline); and (iii) UUO + Act 40 mg/kg/day, (UUO+Act); Continuous gavage administration for 2 weeks postoperatively, while the rats in Sham and UUO+saline groups were given equal amounts of saline. All rats were sacrificed after 14 days, the urine and blood samples were collected for biochemical analysis, the renal tissues were collected for pathological staining and immunohistochemistry. Correlations between individual proteins were analyzed by Pearson correlation analysis. Results The results of renal function indexes and histopathological staining showed that Act could improve renal function by reducing serum creatinine, blood urea nitrogen and urine protein at the same time, Act could alleviate renal inflammation and fibrosis. In addition, the results of immunohistochemistry showed that Act could reduce the expression of inflammation and kidney injury-related proteins F4/80, Mcp-1, KIM-1 proteins, as well as the expression of fibrosis-related protein α-SMA and β-catenin. More importantly, Act can also reduce the expression of HMGN1, TLR4 and TREM-1 proteins. Conclusion These data demonstrate that Act can ameliorate UUO-induced renal inflammation and fibrosis in rats probably through triggering HMGN1/TLR4/TREM-1 pathway.

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Section: Discussionmentioning

confidence: 99%

Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway

Mao

et al. 2023

PeerJ

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“…There are several biological effects underlying the anticancer activity of acteoside, and numerous investigations have disclosed the molecular mechanisms responsible for those effects. The main effects are oxidative stress, apoptosis, and antiproliferative, antiangiogenesis, antimetastasis, anti-invasion, antitumor, and anti-inflammatory effects, and synergistic effects with anticancer drugs [ 24 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is a widely distributed compound in the plant kingdom that was detected in more than 200 plant species representing 23 plant families [ 13 , 22 ]. All scientific information regarding the compound demonstrated a wide range of biological activities, including antioxidant, anti-inflammatory, antiepileptic, neuroprotective, antifungal, antiviral, and anticancer [ 13 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Phenylethanoid Glycosides Isolated from Plantago lanceolata L.

Budzianowska

Totoń

Romaniuk-Drapała

et al. 2023

Life

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The aim of the study is to investigate whether the bioactive compounds isolated from P. lanceolata inflorescences, namely, phenylethanoid glucosides, acteoside, plantamajoside, and a flavonoid, isorhamnetin-3-O-rutinoside-4′-O-glucoside, possessed cytotoxic activity against the selected cancer cell lines. The potential antitumor effects of two phenylethanoid glycosides and one flavonoid were evaluated via MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on seven human carcinoma cell lines (MCF-7, MDA-MB-231, Caco-2, HepG2, OVCAR-3, U138-MG, U251-MG) and one nontumorigenic mammary epithelial cell line (MCF-12A). For the first time, acteoside was studied in ovarian cancer cell line OVCAR-3, and plantamajoside in all cell lines except breast adenocarcinoma MDA-MB-281 and hepatocarcinoma HepG2. The phenylethanoid glycosides showed stronger cytotoxic activity than that of the glycoside flavonoid. Acteoside and plantamajoside, at concentrations of 200 and 300 μM, respectively, had a highly toxic effect on the selected two cancer cell lines of breast adenocarcinoma MDA-MB-231 and MCF-7, ovarian cancer cell line OVCAR-3, glioblastoma cell line U138-MG, and hepatocarcinoma cell line HepG2. Both glycosides were significantly less cytotoxic towards nontumorigenic cell line MCF-12A; the effect appeared at a concentration of 400 μM. For the first time, the activity of acteoside and plantamajoside was compared in one parallel investigation. The results are discussed against a broad background of existing knowledge on biological effects, their mechanisms, and structure–activity relationships. Phenylethanoids may be potential compounds with cytotoxic activity against the selected cancer types.

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“…It was worth noting that the metabolic pathways of pyrrolidine alkaloids were revealed for the first time, mainly including hydrophysis, oxidation, and demethylation. Moreover, acetylene glycosides [22] and phenylpropanoids [23], characteristic components in CR, are generally considered to have poor oral bioavailability. Therefore, in our results, these prototypes and metabolites were not detected in vivo.…”

Section: Sesquiterpene Lactone-metabolites In Biosamplesmentioning

confidence: 99%

Chemical and metabolic profiling of Codonopsis Radix extract with an integrated strategy using ultra‐high‐performance liquid chromatography coupled with mass spectrometry

Tang

Zeng

Wang

et al. 2022

J of Separation Science

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Codonopsis radix was commonly used as food materials or herbal medicines in many countries. However, the comprehensive analysis of chemical constituents, and in vivo xenobiotics of Codonopsis radix remain unclear. In the present study, an integrated strategy with feature-based molecular networking using ultrahigh-performance liquid chromatography coupled with mass spectrometry was established to systematically screen the chemical constituents and the in vivo xenobiotics of Codonopsis radix. A step-by-step manner based on a composition database, visual structure classification, discriminant ions, and metabolite software prediction was proposed to overcome the complexities due to the similar structure of chemical constituents and metabolites of Codonopsis radix. As a result, 103 compounds were tentatively characterized, 20 of which were identified by reference standards. Besides, a total of 50 xenobiotics were detected in vivo, including 26 prototypes and 24 metabolites, while the metabolic features of the pyrrolidine alkaloids were elucidated for the first time. The metabolism reactions of pyrrolidine alkaloids and sesquiterpene lactones included oxidation, methylation, hydration, hydrogenation, demethylation, glucuronidation, and sulfation. This study provided a generally applicable approach to the comprehensive investigation of the chemical and metabolic profile of traditional Chinese medicine and offered reasonable guidelines for further screening of quality control indicators and pharmacodynamics mechanism of Codonopsis radix.

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The pharmacokinetic property and pharmacological activity of acteoside: A review

Cited by 54 publications

References 158 publications

Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway

Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway

Cytotoxic Effect of Phenylethanoid Glycosides Isolated from Plantago lanceolata L.

Chemical and metabolic profiling of Codonopsis Radix extract with an integrated strategy using ultra‐high‐performance liquid chromatography coupled with mass spectrometry

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