Verbal working memory in schizophrenia: The role of syntax in facilitating serial recall

Li, Adrienne; Viñas-Guasch, Nestor; Hui, Christy Lai Ming; Chang, Wing Chung; H, Lee; Chen, Eric

doi:10.1016/j.schres.2017.04.008

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…This cognitive impairment emerges during adolescence, indicating a potential neurodevelopmental cognitive marker [7]. Interestingly, EVM is an important predictor of daily-life functioning in SZ, including performance at work, social behavior, and the capacity for daily-life activities [8, 9]. Furthermore, first-degree relatives of individuals with SZ show deficits in all memory domains, especially verbal memory, compared to healthy controls (HC) [10-12].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings

Rebouças

Rabelo‐da‐Ponte

Massuda

et al. 2018

Neuroimmunomodulation

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Background: Verbal memory impairment may be considered an endophenotype in schizophrenia (SZ), also affecting the siblings of SZ subjects. Furthermore, the immune-inflammatory system response has an important modulatory effect on brain processes, especially on memory circuits. Objective: Investigating the relationship between TNF-α and IL-6 and memory performance in patients with SZ, their unaffected siblings (SB) and healthy controls (HC). Methods: 35 subjects with SZ, 36 SB, and 47 HC underwent a neurocognitive assessment for verbal memory by means of the revised Hopkins Verbal Learning Test (HVLT-R) in addition to serum cytokines analyses. Results: SZ patients performed worse in HVLT-R than SB and HC, but SB and HC were not different. Regarding the biomarker levels, we found significant results of TNF-α for both groups. However, we did not find differences between groups after multiple-comparisons analysis. There were no significant correlations between episodic verbal memory, TNF-α, and IL-6. Conclusion: The results are compatible with the hypothesis that deficits in verbal memory of individuals with SZ could be secondary to inadequate functioning of cognitive processing areas, such as proactive cognitive control.

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Section: Introductionmentioning

confidence: 99%

The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings

Rebouças

Rabelo‐da‐Ponte

Massuda

et al. 2018

Neuroimmunomodulation

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“…Healthy subjects show increased delta-band power during working memory encoding of syntactically structured relative to unstructured word sequences (Bonhage et al, 2017). In contrast, working memory encoding in schizophrenia patients does not benefit much from syntactic structure (Li et al, 2018).…”

Section: Prosody and Syntax: Abnormal Delta-band Oscillations?mentioning

confidence: 85%

“…Martin, 2020). Schizophrenia patients do not reliably detect syntactic errors (Moro et al, 2015) and their working memory benefits less from syntactic structure (i.e., no sentence superiority effect; Bonhage et al, 2017;Li et al, 2018). Alternatively, syntactic rules might be intact, but their top-down influence on perception is temporally distorted (Rochester et al, 1973).…”

Section: Prosody and Syntax: Abnormal Delta-band Oscillations?mentioning

confidence: 99%

Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)?

Meyer¹,

Lakatos²,

He³

2020

Preprint

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Deficits in language production and comprehension are characteristic of schizophrenia. To date, it remains unclear whether these deficits arise from dysfunctional linguistic knowledge, or dysfunctional predictions derived from the linguistic context. Alternatively, the deficits could be a result of dysfunctional neural tracking of auditory information resulting in decreased auditory information fidelity and even distorted information. Here, we discuss possible ways for clinical neuroscientists to employ neural tracking methodology to independently characterize deficiencies on the auditory–sensory and abstract linguistic levels. This might lead to a mechanistic understanding of the deficits underlying language related disorder(s) in schizophrenia. We propose to combine naturalistic stimulation, measures of speech–brain synchronization, and computational modeling of abstract linguistic knowledge and predictions. This orthogonal assessment may be exploited for an objective and differential diagnosis of schizophrenia, as well as a better understanding of the disorder on the functional level—illustrating the potential of neural tracking methodology as translational tool in a range of psychotic populations.

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“…Thus, the artificiality of many experiments has consequently led to some researchers questioning whether their findings can be generalized to real life. Second, we have not used semantic clustering in order to quantify how memory recall was organized, a very interesting measure since previous research has confirmed FEP differed in how they organized memories (Murty et al, 2018), and other possible linguistic impairments that make utilizing syntactic information difficult (Li et al, 2018). Third, by using structural MRI, we reported in patients decreased regional gray matter volumes in specific frontal and occipital regions related to forgetting, proactive and retroactive interference, as potential regions contributing to verbal memory deficit.…”

Section: Discussionmentioning

confidence: 99%

Verbal memory and voxel based morphometry in first episode non-affective psychosis: A process oriented approach.

Ayesa-Arriola¹,

Tordesillas‐Gutiérrez²,

Setién-Suero³

et al. 2019

Neuropsychology

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Objective: The present study aimed to comprehensively study the specific neurocognitive constructs underlying verbal memory deficits and their neuroanatomical correlates in first episode psychosis (FEP) patients. Method: A total of 218 FEP patients and 145 healthy participants were examined with the Rey Auditory Verbal Learning Test (a widely used verbal memory measure that provides a range of performance indexes to evaluate memory) and voxel-based morphometry (a neuroimaging analysis technique that allows investigation of focal differences in brain anatomy). Results: The analyses showed that the FEP group presented significantly lower scores on acquisition/learning, F(1, 566) = 40.7; p < .001, and delayed recall, F(1, 570) = 74.12; p < .001, as well as higher rates of forgetting, F(1, 566) = 20.03; p < .001. They also exhibited a significant sensitivity to retroactive, F(1, 554) = 8.74; p = .003, but not to proactive interference. Neuroimaging analyses found significant interactions between bilateral frontal lobe morphometry and proactive interference (ρFWE = 0.023). Rate of forgetting also significantly interacted with right occipital cortex morphometry (ρFWE = 0.033). Patients with higher rates of forgetting, proactive and retroactive interference demonstrated further gray matter reductions in frontal and occipital cortical areas. Conclusions: These findings emphasize the anterior orbitofrontal cortex as the brain region that contributes to verbal memory deficits in FEP patients, and suggest specific relationships between different neuroanatomical structures and discrete verbal memory processes.

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Verbal working memory in schizophrenia: The role of syntax in facilitating serial recall

Cited by 7 publications

References 37 publications

The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings

The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings

Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)?

Verbal memory and voxel based morphometry in first episode non-affective psychosis: A process oriented approach.

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