Verbal memory performance improved via an acute administration of <scp>D</scp>‐amphetamine

Zeeuws, Inge; Soetens, Eric

doi:10.1002/hup.848

Cited by 35 publications

(45 citation statements)

References 50 publications

(55 reference statements)

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“…These initial studies were later confirmed by studies showing enhanced memory consolidation (Soetens et al 1993), memory recall (Zeeuws and Soetens 2007), attention and psychomotor performance (Johnson et al 2000;Silber et al 2006), information processing (Halliday et al 1994), logical reasoning (Johnson et al 2000), and working memory (Mattay et al 2000) by amphetamine and its derivatives such as dextroamphetamine in humans. Because of its attention-improving properties amphetamine was used to treat ADHD but then this treatment was replaced by drugs with fewer psychoactive side effects (Wilens et al 2008).…”

Section: Amphetaminementioning

confidence: 82%

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

2016

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It has long been hypothesized that conditioning mechanisms play major roles in addiction. Specifically, the associations between rewarding properties of drugs of abuse and the drug context can contribute to future use and facilitate the transition from initial drug use into drug dependency. On the other hand, the self-medication hypothesis of drug abuse suggests that negative consequences of drug withdrawal result in relapse to drug use as an attempt to alleviate the negative symptoms. In this review, we explored these hypotheses and the involvement of the hippocampus in the development and maintenance of addiction to widely abused drugs such as cocaine, amphetamine, nicotine, alcohol, opiates, and cannabis. Studies suggest that initial exposure to stimulants (i.e., cocaine, nicotine, and amphetamine) and alcohol may enhance hippocampal function and, therefore, the formation of augmented drug-context associations that contribute to the development of addiction. In line with the self-medication hypothesis, withdrawal from stimulants, ethanol, and cannabis results in hippocampus-dependent learning and memory deficits, which suggest that an attempt to alleviate these deficits may contribute to relapse to drug use and maintenance of addiction. Interestingly, opiate withdrawal leads to enhancement of hippocampus-dependent learning and memory. Given that a conditioned aversion to drug context develops during opiate withdrawal, the cognitive enhancement in this case may result in the formation of an augmented association between withdrawalinduced aversion and withdrawal context. Therefore, individuals with opiate addiction may return to opiate use to avoid aversive symptoms triggered by the withdrawal context. Overall, the systematic examination of the role of the hippocampus in drug addiction may help to formulate a better understanding of addiction and underlying neural substrates.Addiction is a major worldwide health problem that results in maladaptive behavioral changes, some that can last a lifetime. This behavioral plasticity, often times maladaptive, must be associated changes in neural plasticity. In fact, it has been noted multiple times that there is a high degree of overlap between the neurobiology of learning and memory and the neurobiology of addiction

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Section: Amphetaminementioning

confidence: 82%

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

2016

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“…Although research shows practically no cognitive benefit of either methylphenidate or amphetamine on acquisition (Advokat, 2010), there is some evidence that stimulants might improve retention of previously acquired information ( Izquierdo et al, 2008;Soetens et al, 1993;Zeeuws & Soetens, 2007). In a series of experiments by Soetens and colleagues, nonADHD adult males received placebo and amphetamine, in a within-subject experimental procedure.…”

Section: Wwwintechopencommentioning

confidence: 99%

Do Stimulant Medications for Attention-Deficit/Hyperactivity Disorder (ADHD) Enhance Cognition?

Advokat¹,

Vinci²

2012

Current Directions in ADHD and Its Treatment

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“…Moreover, it has been found that amphetamine also modulates the retrieval phase of memory processes in healthy subjects. More specifically, an enhancement of memory retrieval in nonstress condition has been reported (Sara and Deweer 1982;Altman and Quatermain 1983;Quatermain et al 1988;Quatermain and Jung 1989) even though negative findings have also been described (Zeeuws and Soetens 2007). Whereas the effects of amphetamine on memory storage in stress condition have been extensively described (Kant 1993;Cabib and Castellano 1997;Reid et al 1998; Barr et al 2002;Matuszewich and Yamamoto 2004), there are as yet to our knowledge no available data concerning the combined effects of amphetamine and acute stress on memory retrieval pattern.…”

Section: Introductionmentioning

confidence: 90%

“…Numerous studies have already well established that amphetamine interacts with cognitive functions (Barch and Carter 2005), mainly with memory storage and memory consolidation processes (Strupp et al 1991;Soetens et al 1993;Zeeuws and Soetens 2007). Moreover, it has been found that amphetamine also modulates the retrieval phase of memory processes in healthy subjects.…”

Section: Introductionmentioning

confidence: 96%

Combined effects of acute stress and amphetamine on serial memory retrieval pattern in mice

Piérard¹,

Tronche

Liscia³

et al. 2008

Psychopharmacology

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Results showed that: (1) vehicle group expressed in both tasks a similar memory retrieval pattern, D2 being better retrieved than D1; (2) 2 mg/kg amphetamine significantly enhanced D1 but not D2 performance in both tasks, whereas 4 mg/kg amphetamine enhanced D2 but not D1 retrieval. Thus, amphetamine more specifically modulates serial order memory retrieval in a context-independent manner. In a further step, we studied the effect of an acute stress (electric foot shocks 5 min before retrieval) specifically on D1 performance of the CSD task in 2 mg/kg amphetamine-treated mice. Immediately after testing, blood was sampled to measure plasma corticosterone levels. Results showed that acute stress significantly improved D1 performance in vehicles but blocked the memory-enhancing effect of 2 mg/kg amphetamine, as compared to the nonstress condition. However, statistical analysis failed to evidence a significant interaction between treatments and conditions (stress vs nonstress) on corticosterone levels, contrary to another vigilance-enhancing drug, modafinil (Béracochéa, Psychopharmacology 196:1-13, 2008).

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Verbal memory performance improved via an acute administration of D‐amphetamine

Cited by 35 publications

References 50 publications

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction

Do Stimulant Medications for Attention-Deficit/Hyperactivity Disorder (ADHD) Enhance Cognition?

Combined effects of acute stress and amphetamine on serial memory retrieval pattern in mice

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