Combined effects of acute stress and amphetamine on serial memory retrieval pattern in mice

Piérard, Christophe; Tronche, Christophe; Liscia, Pierrette; Chauveau, Frédéric; Béracochéa, Daniel

doi:10.1007/s00213-008-1391-5

Cited by 8 publications

(4 citation statements)

References 32 publications

(44 reference statements)

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“…However, although elevated levels of plasma CORT have been largely hypothesized to contribute to age-related memory decline (Cameron and Gould, 1994; Lupien et al, 1998; Yau and Seckl, 2012), few studies focus on the measurement of intrahippocampal CORT levels in aged rodents in relation to memory retrieval performance. Interestingly, it has been recently shown that stress-induced intrahippocampal CORT rise in middle-aged rats was associated with memory impairments in a hippocampal-dependent memory task (Chauveau et al, 2009b) that has been previously shown to be affected in middle-aged mice (Celerier et al, 2004; Beracochea et al, 2008a,b; Chauveau et al, 2009a,b; Pierard et al, 2009; Tronche et al, 2010). The magnitude of intracellular CORT action in the rodent hippocampus is thought to be determined by the hippocampal activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that regenerates active CORT within cells, but also by free CORT circulating in blood and delivered to the brain (Seckl, 1997).…”

Section: Introductionmentioning

confidence: 99%

Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory

Bonhomme

Pallet

Dominguez

et al. 2014

Front. Aging Neurosci.

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It is now established that vitamin A and its derivatives, retinoic acid (RA), are required for cognitive functions in adulthood. RA hyposignaling and hyperactivity of glucocorticoid (GC) pathway appear concomitantly during aging and would contribute to the deterioration of hippocampal synaptic plasticity and functions. Furthermore, recent data have evidenced counteracting effects of retinoids on GC signaling pathway. In the present study, we addressed the following issue: whether the stimulation of RA pathway could modulate intrahippocampal corticosterone (CORT) levels in middle-aged mice and thereby impact on hippocampal plasticity and cognitive functions. We firstly investigated the effects of vitamin A supplementation and RA treatment in middle-aged mice, on contextual serial discrimination task, a paradigm which allows the detection of early signs of age-related hippocampal-dependent memory dysfunction. We then measured intrahippocampal CORT concentrations by microdialysis before and after a novelty-induced stress. Our results show that both RA treatment and vitamin A supplementation improve “episodic-like” memory in middle-aged mice but RA treatment appears to be more efficient. Moreover, we show that the beneficial effect of RA on memory is associated to an increase in hippocampal PSD-95 expression. In addition, intrahippocampal CORT levels are reduced after novelty-induced stress in RA-treated animals. This effect cannot be related to a modulation of hippocampal 11β-HSD1 expression. Interestingly, RA treatment induces a modulation of RA receptors RARα and RARβ expression in middle-aged mice, a finding which has been correlated with the amplitude of intrahippocampal CORT levels after novelty-induced stress. Taken together, our results suggest that the preventive action of RA treatment on age-related memory deficits in middle-aged mice could be, at least in part, due to an inhibitory effect of retinoids on GC activity.

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Section: Introductionmentioning

confidence: 99%

Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory

Bonhomme

Pallet

Dominguez

et al. 2014

Front. Aging Neurosci.

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“…This task allowed to evidence a hippocampal-dependent memory impairment in stressed (Celerier et al, 2004; Piérard et al, 2009) as well as in middle-aged (Tronche et al, 2010a) and aged subjects (Tronche et al, 2010b). More precisely, the CSD task involves two serial discriminations (D1 and D2) learned on two different contexts.…”

Section: Introductionmentioning

confidence: 99%

Interaction between Diazepam and Hippocampal Corticosterone after Acute Stress: Impact on Memory in Middle-Aged Mice

Béracochéa

Tronche²,

Coutan³

et al. 2011

Front. Behav. Neurosci.

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Benzodiazepines (BDZ) are widely prescribed in the treatment of anxiety disorders associated to aging. Interestingly, whereas a reciprocal interaction between the GABAergic system and HPA axis has been evidenced, there is to our knowledge no direct evaluation of the impact of BDZ on both hippocampus (HPC) corticosterone concentrations and HPC-dependent memory in stressed middle-aged subjects. We showed previously that an acute stress induced in middle-aged mice severe memory impairments in a hippocampus-dependent task, and increased in parallel hippocampus corticosterone concentrations, as compared to non-stressed middle-aged controls (Tronche et al., 2010). Based on these findings, the aims of the present study were to evidence the impact of diazepam (a positive allosteric modulator of the GABA-A receptor) on HPC glucocorticoids concentrations and in parallel on HPC-dependent memory in acutely stressed middle-aged mice. Microdialysis experiments showed an interaction between diazepam doses and corticosterone concentrations into the HPC. From 0.25 to 0.5 mg/kg, diazepam dose-dependently reduces intra-HPC corticosterone concentrations and in parallel, dose-dependently increased hippocampal-dependent memory performance. In contrast, the highest (1.0 mg/kg) diazepam dose induces a reduction in HPC corticosterone concentration, which was of greater magnitude as compared to the two other diazepam doses, but however decreased the hippocampal-dependent memory performance. In summary, our study provides first evidence that diazepam restores in stressed middle-aged animals the hippocampus-dependent response, in relation with HPC corticosterone concentrations. Overall, our data illustrate how stress and benzodiazepines could modulate cognitive functions depending on hippocampus activity.

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“…Given the data concerning the relationship between the retinoid pathway and GCs, the question of the involvement of the HPA axis in the mediation of these retinoid effects and their repercussions on memory is crucial. Indeed, it has been recently shown that the rise in intrahippocampal corticosterone levels in middle-aged mice is associated with memory impairments in a hippocampus-dependent memory task [80] known to be affected in midlife [81][82][83][84][85][86]. RA treatment in middle-aged mice reduces and delays the increase in intrahippocampal corticosterone after exposure to a novel environment, and restores memory performance in this task [87].…”

Section: Ra Treatment: a Strategy To Modulate Hippocampal Gc Availabimentioning

confidence: 99%

Vitamin A and cognitive processes

Pallet

Touyarot

2015

NUA

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Vitamin A and its derivatives, the retinoids, essential for human health, modulate several physiological processes through their interactions with the nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). They are involved in the modulation of cerebral plasticity including hippocampal neurogenesis and synaptic plasticity, known to underlie cognitive processes. Interestingly, retinoic acid (RA) hyposignaling, which contributes to the deterioration of hippocampal plasticity and function during aging, can be reversed by vitamin A supplementation or RA treatment. However, it is still not clear how vitamin A status modulates plasticity and memory. It is commonly accepted that RA, by binding to its specific nuclear receptors, regulates gene expression, including the expression of plasticity-related genes. Moreover, recent studies suggest that vitamin A could participate in the maintenance of neurobiological functions indirectly, through the glucocorticoid pathway. Here, we present data supporting the importance of vitamin A status in the maintenance of memory processes, and the contribution of naturally occurring RA hyposignaling during aging to the etiology of cognitive decline. We propose that vitamin A supplementation or RA treatment could be a potent way to prevent age-related cognitive impairments by maintaining normal vitamin A and glucocorticoid (GC) status in seniors.

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Combined effects of acute stress and amphetamine on serial memory retrieval pattern in mice

Cited by 8 publications

References 32 publications

Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory

Retinoic acid modulates intrahippocampal levels of corticosterone in middle-aged mice: consequences on hippocampal plasticity and contextual memory

Interaction between Diazepam and Hippocampal Corticosterone after Acute Stress: Impact on Memory in Middle-Aged Mice

Vitamin A and cognitive processes

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