Verbal fluency dysfunction in euthymic bipolar patients: A controlled study

Rocca, Cristiana Castanho de Almeida; Macedo-Soares, Márcia Britto de; Gorenstein, Clarice; Tamada, Renata Sayuri; Isller, Cilly Kluger; Dias, Rebecca; Almeida, Karla Mathias de; Schwartzmann, Angela Maria; Amaral, José Antônio; Lafer, Beny

doi:10.1016/j.jad.2007.07.013

Cited by 26 publications

(15 citation statements)

References 28 publications

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“…Results are consistent with previous findings that indicate a significantly worse functioning of phonetic verbal fluency measured by FAS test in the group of patients during depression compared to healthy subjects [3,8]. Many studies show worse functioning of verbal fluency in patients with severe episode of depression [27] and in patients with bipolar disorder in remission [28].…”

Section: Discussionsupporting

confidence: 91%

“…Archives of Psychiatry and Psychotherapy, 2014; 4 : [27][28][29][30][31][32][33][34][35][36][37] However, the significantly poorer execution of part B can also be caused by disturbances in the main control system, that is in executive functions. Research studies with neurosurgical patients show that the prolonged time in TMT test is associated with impaired functioning in the frontal brain.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive functioning in depression period of bipolar disorder

Świtalska¹,

Borkowska²

2014

Arch Psych Psych

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SummaryAim of the study. Study aims were to compare neuropsychological functioning of depressed bipolar patients and healthy controls and to estimate relationship between severity of depressive symptoms and cognitive functioning. Method. Cognitive functions were examined in 30 depressed bipolar patients aged 6, SD= 12,6; 18 women and 12 men) who fulfilled ICD-10 criteria for depressive episode (Hamilton Depression Rating Scale score ≥11). The comparison group consisted of 30 healthy subjects aged 23-71 (M=46, 20 women and 10 men) matched in age, years of education and gender to bipolar group. A neuropsychological battery assessed executive functions and working memory. Results. The bipolar patients in depression revealed neuropsychological deficits in working memory and some aspects of executive functions in comparison to healthy group. Only in WCST test both groups received similar results. Neuropsychological functioning seems to be independent of the severity of depressive symptoms. Discussion. Different aspects of working memory and executive functions are impaired in depression period of bipolar disorder and they seem independent of the severity of depressive symptoms. These results are consistent with previous reports. Conclusions. In patients with bipolar depression cognitive assessment should be taken into account in the diagnosis and the disturbances in executive functions and working memory should be treated with neuropsychological rehabilitation and / or pharmacotherapy. bipolar disorder / neurocognitive impairment / depression

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Cognitive functioning in depression period of bipolar disorder

Świtalska¹,

Borkowska²

2014

Arch Psych Psych

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“…According to other authors, the performance on the executive function measures was bimodal among euthymic BD patients (one subgroup with relatively normal and one subgroup with impaired executive functioning) (Altshuler et al 2004 ). Some studies report no difference in executive function between BD patients and controls (Paradiso et al 1997 ;de Almeida Rocca et al 2008 ;Fleck et al 2008 ;Olley et al 2005 ;Thompson et al 2007 ;Friedman et al 1977 ), while one study suggested that impairment is present only in the more severe and chronic cases (de Almeida Rocca et al 2008 ).…”

Section: Executive Functionmentioning

confidence: 97%

“…Although verbal skills are reported to be impaired during all phases of BD (Martinez-Aran et al 2004 ;Zubieta et al 2001 ;Docherty et al 1996 ;Kremen et al 2003 ;de Almeida Rocca et al 2008 ;Martinez-Aran et al 2008 ;Simonsen et al 2011 ;Atre-Vaidya et al 1998 ), there are some papers suggesting that this impairment is not present during euthymia (Zalla 4.5 Verbal Skills et al 2004 ;Altshuler et al 2004 ) or during the fi rst mood episode (Barrett et al 2009 ). Errors in speech are reported during the acute manic state, and they are independent from the coexistence of an attentional defi cit (Thomas et al 1996 ).…”

Section: Verbal Skillsmentioning

confidence: 99%

“…In the absence of current psychotic symptoms, a history of psychotic features is also strongly related to worse neurocognitive function (Simonsen et al 2011 ;de Almeida Rocca et al 2008 ) especially concerning measures of executive functioning and verbal and spatial working memory (Glahn et al 2007 ;Martinez-Aran et al 2008 ). However, this effect is modest, and there does not seem to exist a complete categorical distinction between psychotic and nonpsychotic BD (Bora et al 2010b ).…”

Section: The Effect Of Psychotic Symptomsmentioning

confidence: 99%

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