Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

Fountoulakis, Kostas N.

doi:10.1007/978-3-642-37216-2_4

Cited by 4 publications

(3 citation statements)

References 372 publications

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“…During the last few decades there were important developments both in our understanding of BD but also in its treatment ( Fountoulakis, 2015a , 2015b , 2015c , 2015d , 2015e , 2015f ). In many instances the accumulation of new knowledge challenged old beliefs that dominated the psychiatric academic thinking and practice for decades.…”

Section: Introductionmentioning

confidence: 99%

The International College of Neuro-Psychopharmacology (CINP) treatment guidelines for Bipolar disorder in adults (CINP-BD-2017), part 3: The clinical guidelines.

Fountoulakis

Grunze

Vieta

et al. 2016

IJNPPY

168

316

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Background:The current paper introduces the actual International College of Neuro-Psychopharmacology clinical guidelines for the treatment of bipolar disorder.Concept and structure of the guidelines:The current clinical guidelines are based on evidence-based data, but they also intend to be clinically useful, while a rigid algorithm was developed on the basis of firm evidence alone. Monotherapy was prioritized over combination therapy. There are separate recommendations for each of the major phases of bipolar disorder expressed as a 5-step algorithm.Discussion:The current International College of Neuro-Psychopharmacology clinical guidelines for the treatment of bipolar disorder are the most up-to-date guidance and are as evidence based as possible. They also include recommendations concerning the use of psychotherapeutic interventions, again on the basis of available evidence. This adherence of the workgroup to the evidence in a clinically oriented way helped to clarify the role of specific antidepressants and traditional agents like lithium, valproate, or carbamazepine. The additional focus on specific clinical characteristics, including predominant polarity, mixed features, and rapid cycling, is also a novel approach. Many issues need further studies, data are sparse and insufficient, and many questions remain unanswered. The most important and still unmet need is to merge all the guidelines that concern different phases of the illness into a single one and in this way consider BD as a single unified disorder, which is the real world fact. However, to date the research data do not permit such a unified approach.

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Section: Introductionmentioning

confidence: 99%

The International College of Neuro-Psychopharmacology (CINP) treatment guidelines for Bipolar disorder in adults (CINP-BD-2017), part 3: The clinical guidelines.

Fountoulakis

Grunze

Vieta

et al. 2016

IJNPPY

168

316

View full text Add to dashboard Cite

show abstract

“…Not only BD is a much more complex disorder than this, but also the outcome varies. The most prominent clinical facets are shown in Table 1 ( Fountoulakis, 2015a , 2015c , 2015d , 2015e , 2015j , 2015n ).…”

Section: Introductionmentioning

confidence: 99%

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Fountoulakis

Young

Yatham

et al. 2016

IJNPPY

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Background:This paper includes a short description of the important clinical aspects of Bipolar Disorder with emphasis on issues that are important for the therapeutic considerations, including mixed and psychotic features, predominant polarity, and rapid cycling as well as comorbidity.Methods:The workgroup performed a review and critical analysis of the literature concerning grading methods and methods for the development of guidelines.Results:The workgroup arrived at a consensus to base the development of the guideline on randomized controlled trials and related meta-analyses alone in order to follow a strict evidence-based approach. A critical analysis of the existing methods for the grading of treatment options was followed by the development of a new grading method to arrive at efficacy and recommendation levels after the analysis of 32 distinct scenarios of available data for a given treatment option.Conclusion:The current paper reports details on the design, method, and process for the development of CINP guidelines for the treatment of Bipolar Disorder. The rationale and the method with which all data and opinions are combined in order to produce an evidence-based operationalized but also user-friendly guideline and a specific algorithm are described in detail in this paper.

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“…Approximately 30-50% of remitted patients do not regain their premorbid level of psychosocial functioning. Research on neurocognitive functioning and emotion regulation may provide further knowledge about mechanisms underlying poor social functioning in BD [6,7] . This paper represents part of a larger project investigating underlying psychological mechanisms of…”

Section: Introductionmentioning

confidence: 99%

Autobiographical Memory in Bipolar Disorder and Its Link to Neuropsychological Functioning

Quinlivan

Dallacker

Renneberg³

et al. 2017

Psychopathology

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Objective: The aim of this study was to examine the specificity of autobiographical memory (AM) in bipolar disorder (BD) and to investigate the association between AM and neuropsychological functions. Method: Twenty bipolar patients and 22 matched healthy controls (HCs) were included in this study. AM was assessed with an extended version of the Autobiographical Memory Test (AMT) including rejection cue words. A neuropsychological test battery was used to examine verbal memory, executive functions, and attention. Results: Across both groups, the number of specific memories in the AMT was significantly smaller in response to rejection cue words and positive cue words than in response to negative cue words. Participants with BD and HCs did not differ significantly in neuropsychological measures. Across both groups, scores of verbal memory, executive functions, and attention were significantly correlated with specificity of retrieved memories. Limitations: Although our clinical sample consisted of clinically stable outpatients, 6 out of 20 patients were not rated as euthymic but as mildly depressed. All BD patients were medicated. Conclusion: Contrary to previous results, patients with BD did not differ in the number of specific memories compared to an HC group. Our findings suggest that neuropsychological functioning is associated with AMT specificity. Further research is required to gain a better understanding of the underlying mechanisms which may influence the ease of memory retrieval.

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Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

Cited by 4 publications

References 372 publications

The International College of Neuro-Psychopharmacology (CINP) treatment guidelines for Bipolar disorder in adults (CINP-BD-2017), part 3: The clinical guidelines.

The International College of Neuro-Psychopharmacology (CINP) treatment guidelines for Bipolar disorder in adults (CINP-BD-2017), part 3: The clinical guidelines.

The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines

Autobiographical Memory in Bipolar Disorder and Its Link to Neuropsychological Functioning

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