Veränderungen des Linsenepithels bei Diabetikern und Nichtdiabetikern mit verschiedenen Trübungsformen einer altersassoziierten Katarakt12

Struck, H.-G.; Heider, C.; Lautenschläger, Christine

doi:10.1055/s-2000-10545

Cited by 11 publications

(5 citation statements)

References 13 publications

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“…Zaczek and Zetterstrom [ 14 ] reported similar findings at 2 years. A possible explanation for the lower PCO in diabetic patients may be the decreased density of LECs in the diabetic capsular bag [ 15 ] and/or the detrimental effects of accumulating intracellular sorbitol [ 16 ] and fructose, free radicals, and oxidative stress on their survival and proliferative capacities [ 17 ]. These effects may explain the decrease in the incidence of PCO in diabetic patients at longer follow-up periods.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery

Tong

Lin

et al. 2018

Journal of Ophthalmology

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Purpose To evaluate the potential risk factors of posterior capsule opacification (PCO) after cataract surgery. Methods Data on PCO patients diagnosed from September 2015 to May 2017 were obtained from the Department of Ophthalmology at Qingdao Municipal Hospital, Qingdao, China. The factors associated with PCO were assessed using Pearson's χ2 test for univariate analyses and logistic regression for multivariate analyses. Results Eyes (652) from 550 patients were enrolled in this study. All patients were diagnosed with PCO/non-PCO and had <3 years of follow-up after surgery. The numbers of PCO and non-PCO were 108 eyes and 544 eyes, respectively. Statistically significant associations with PCO were found for age at the time of surgery (χ2 = 78.504; p < 0.001), diabetes (χ2 = 4.829; p=0.028), immune diseases (χ2 = 4.234; p=0.004), high myopia (χ2 = 5.753; p=0.016), lens nucleus hardness (χ2 = 11.046; p=0.026), surgery type (χ2 = 11.354; p=0.001), a history of vitrectomy (χ2 = 4.212; p=0.004), ocular inflammation (χ2 = 6.01; p=0.009), and the intraocular lens (IOL) type (χ2 = 8.696; p=0.003). Multivariable data analyses using logistic regression analyses of the variables showed that age at the time of surgery <60 years, diabetes, lens nucleus hardness of III–V, extracapsular cataract extraction (ECCE), postvitrectomy, and hydrophilic IOLs were significant independent risk factors associated with PCO. Conclusions Age <60 years, diabetes, lens nucleus hardness of III–V, ECCE, postvitrectomy, and a hydrophilic IOL were significantly associated with the formation of PCO. Estimation of the incidence of and risk factors for PCO should help in patients counseling and in the design of treatment protocols to reduce or prevent its development.

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Section: Discussionmentioning

confidence: 99%

Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery

Tong

Lin

et al. 2018

Journal of Ophthalmology

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“…Struck et al sought to investigate this issue in their study of lens epithelial cell densities in type-II diabetics vs. non-diabetics undergoing cataract surgery [22]. They collected capsulotomy specimens from 59 human subjects and analyzed the cell density of the LEC with respect to diabetic status and cataract type.…”

Section: Discussionmentioning

confidence: 99%

Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens

Zablocki

Ruzycki

Overturf

et al. 2011

Chemico-Biological Interactions

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Cataract is a key factor in the morbidity associated with diabetes. While the pathogenesis of diabetic cataract formation is poorly understood, previous research has identified aldose reductase (ALR2) as a key player. To elucidate a potential role for this enzyme in diabetic cataract formation, we created a series of transgenic mice designed for expression of human ALR2 (AKR1B1) in epithelial and outer cortical fiber cells of the lens. One of the founder lines, designated PAR39, developed an early onset cataract that involved formation of a plaque of cells at the anterior aspect of the lens. These cells appear to separate from the anterior epithelium and undergo a dramatic change that is reminiscent of the epithelial to mesenchymal transition (EMT). We characterized this phenotype in the PAR39 strain by examining rates of cell proliferation and by immunostaining for markers of EMT. Incorporation of the thymidine analog bromodeoxyuridine (BrdU) was used to estimate cell proliferation in two functional areas of the lens epithelium: the mitotically active germinative zone (GZ) and the less proliferative center zone (CZ). Staining cell nuclei with diamido 4',6-diamidino-2-phenylindole (DAPI) was used to establish a total cell count in the demarcated areas. Lens epithelium in PAR39 transgenic mice demonstrated a decrease in the percentage of BrdU/DAPI staining within the GZ as compared to nontransgenic littermate controls (8.1% vs. 10.9%). A similar decrease in BrdU/DAPI was observed in the CZ (0.6% compared to 3.3%). However, cell density was greater within the GZ of PAR39 mice as compared with nontransgenic controls, while it was not significantly different in the CZ among the two groups. Furthermore, cells associated with the epithelial plaque did not stain positive for BrdU, but were strongly positive for alpha-smooth muscle actin, a classical marker for EMT. These findings suggest that ALR2 over-expression is associated with an alteration in the balance between proliferation and apoptosis of epithelial cells in the mouse lens, and that cells associated with epithelial plaques in the PAR39 lens have features in common with cells undergoing EMT.

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“…age-related cataract, the first changes are -according to the absolute morphological criteriadamages of the fibres of the lens [17]. Tests by Struck et al [30,31] showed the first evidences of damage of the lens epithelium within the scope of the cataractous effect of diabetes mellitus type II. Hence, studies of histomorphological and metabolic changes of the clinically clear human lens are of great importance.…”

Section: Introductionmentioning

confidence: 99%

Changes in the lens epithelium with respect to cataractogenesis—light microscopic and Scheimpflug densitometric analysis of the cataractous and the clear lens of diabetics and non-diabetics

Tkachov

Lautenschläger

Ehrich

et al. 2005

Graefe's Arch Clin Exp Ophthalmo

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Veränderungen des Linsenepithels bei Diabetikern und Nichtdiabetikern mit verschiedenen Trübungsformen einer altersassoziierten Katarakt12

Cited by 11 publications

References 13 publications

Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery

Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery

Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens

Changes in the lens epithelium with respect to cataractogenesis—light microscopic and Scheimpflug densitometric analysis of the cataractous and the clear lens of diabetics and non-diabetics

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