Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery

Abstract

Purpose To evaluate the potential risk factors of posterior capsule opacification (PCO) after cataract surgery. Methods Data on PCO patients diagnosed from September 2015 to May 2017 were obtained from the Department of Ophthalmology at Qingdao Municipal Hospital, Qingdao, China. The factors associated with PCO were assessed using Pearson's χ2 test for univariate analyses and logistic regression for multivariate analyses. Results Eyes (652) from 550 patients were enrolled in this study. All patients were diagnosed with PCO/non-PCO and had <3 years of follow-up after surgery. The numbers of PCO and non-PCO were 108 eyes and 544 eyes, respectively. Statistically significant associations with PCO were found for age at the time of surgery (χ2 = 78.504; p < 0.001), diabetes (χ2 = 4.829; p=0.028), immune diseases (χ2 = 4.234; p=0.004), high myopia (χ2 = 5.753; p=0.016), lens nucleus hardness (χ2 = 11.046; p=0.026), surgery type (χ2 = 11.354; p=0.001), a history of vitrectomy (χ2 = 4.212; p=0.004), ocular inflammation (χ2 = 6.01; p=0.009), and the intraocular lens (IOL) type (χ2 = 8.696; p=0.003). Multivariable data analyses using logistic regression analyses of the variables showed that age at the time of surgery <60 years, diabetes, lens nucleus hardness of III–V, extracapsular cataract extraction (ECCE), postvitrectomy, and hydrophilic IOLs were significant independent risk factors associated with PCO. Conclusions Age <60 years, diabetes, lens nucleus hardness of III–V, ECCE, postvitrectomy, and a hydrophilic IOL were significantly associated with the formation of PCO. Estimation of the incidence of and risk factors for PCO should help in patients counseling and in the design of treatment protocols to reduce or prevent its development.

Dexamethasone Intracanalicular Insert: A Review in Treating Post-Surgical Ocular Pain and Inflammation

“…Corticosteroid eye drops may be prescribed following ophthalmic surgery, as inflammation is a risk factor for complications such as pain [3] and conditions associated with visual degradation such as cystoid macular oedema [3] or posterior capsule opacification [4] following cataract surgery. However, adherence with corticosteroid eye drops may decrease due to the dosing frequency (multiple administrations daily) [3], and may be exacerbated by generally poor administration techniques with eye drops, as seen in an observational study (≈ 20-30% of glaucoma patients successfully instilled a drop without touching the tip of the bottle) [5].…”

Optic shrinkage and retraction in opacified hydrophilic acrylic intraocular lens: an anterior segment optical CT-based observation

“…However, it is to be remembered that both increased rates of IOL opacification and PCO have been independently associated with postoperative inflammation and hydrophilic IOLs, and there may be chances that an advanced form of IOL opacification and formation of Elschnig’s pearls in our patient could have occurred due to these common underlying factors 4 11. Nevertheless, it is unlikely that such asymmetrical PC changes and IOL opacification occur due to the same material in the same patient operated by the same surgeon.…”

PREVENTION AND MANAGEMENT OF Diabetes-Related Eye Disease

“…Approximately 30% of people who have cataract surgery will develop a PCO in the months or years after their procedure (76). Younger people have a higher rate of PCOs (76).…”

“…Approximately 30% of people who have cataract surgery will develop a PCO in the months or years after their procedure (76). Younger people have a higher rate of PCOs (76). There are conflicting reports of whether PCOs are more common in patients with diabetes (76).…”

“…Younger people have a higher rate of PCOs (76). There are conflicting reports of whether PCOs are more common in patients with diabetes (76). However, we know that many patients with diabetes are younger at the time of their cataract surgery, so many of them will end up with a PCO sometime after surgery.…”