Ver�nderungen der Serumeiwei?k�rper und der proteingebundenen Kohlenhydrate bei Diabetes mellitus

McMillan, D. E.

doi:10.1007/bf00418228

Cited by 34 publications

(10 citation statements)

References 38 publications

(40 reference statements)

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“…The plasma volume decreases more rapidly in diabetes in these circumstances (9). In contrast to the elevated serum protein levels found in ambulatory outpatient diabetics in this study (Table III), hospitalized diabetics have depressed serum protein levels (27). The control subjects and diabetic and nondiabetic patients in this study came from their residence to the laboratory, usually by automobile.…”

Section: Discussionmentioning

confidence: 55%

Disturbance of Serum Viscosity in Diabetes Mellitus

McMillan¹

1974

J. Clin. Invest.

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112

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A B S T R A C T The serum viscosity of diabetic patients has been found to be increased. The elevation averaged 8% above healthy subjects and 6% above nondiabetic patients. The serum viscosity elevation was greater when diabetic sequelae associated with microangiopathy were present. No relation of serum viscosity to age, sex, obesity, duration of disease, or type of treatment was demonstrated. Serum total protein and glucose levels were found to be correlated with serum viscosity, and increases in their serum concentrations were observed in diabetes. Analysis demonstrated that their elevation did not explain either the viscosity increase or the difference in viscosity between diabetics with and without sequelae.Intrinsic viscosity, abbreviated [n], is a concentrationindependent solute property related to molecular shape.[n] was found to be 7% higher in diabetic than in normal serum. The [X7] difference accounted for at least half of the serum viscosity elevation. The rest of the increase was due to increased serum protein level and increased nonprotein solids, presumably glucose and lipid. Associated with increased [n] was a decline in albumin: globulin ratio and elevation of the acute phase reactant proteins, al-acid glycoprotein, al-antitrypsin, haptoglobin, and ceruloplasmin. Studies comparing diabetic and normal serum fractionated by using 21.5% sodium sulfate showed that changes in [n] were attributable to changes in serum protein composition rather than an inherent qualitative disturbance of protein present in one of the fractions.

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Section: Discussionmentioning

confidence: 55%

Disturbance of Serum Viscosity in Diabetes Mellitus

McMillan¹

1974

J. Clin. Invest.

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112

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“…Other workers have shown a relationship between an increased a2-globulin level and the presence of diabetic vascular complications [12,13,14]. In juvenile diabetic patients raised levels of serum haptoglobin have been reported in patients with angiopathy and increased haptoglobin levels have been shown to be associated with diabetic complications, but not with the duration of the diabetic state [15].…”

Section: Discussionmentioning

confidence: 96%

Blood glycoprotein levels in diabetes mellitus

Jónsson

Wales

1976

Diabetologia

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Summary. Five glycoproteins have been measured in the blood of 145 diabetic patients with and without clinical evidence of complications. Patients with diabetic complications have higher glycoprotein levels particularly when expressed as a ratio to serum albumin levels. In 32 pairs of patients matched for age, sex, body weight, duration and treatment of diabetes, significantly higher haptoglobin, fibrinogen and caeruloplasmin levels were associated with the presence of diabetic complications, but blood glucose levels were not significantly different, fi-lipoprotein levels were positively correlated with age and a2-macroglobulin levels with the duration of clinical disease, but the type of antidiabetic therapy administered did not significantly alter glycoprotein levels. It is suggested that rising levels of certain glycoproteins in the blood of diabetic patients may indicate the development of diabetic vascular complications, but a prospective study is required before it can be decided whether this change predates the clinical appearance of the complications.

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“…5 Since then, much interest has focused on the glycosylated hemoglobins, HbA 1(a+b+c) , both as a reliable index of overall glycemic control during the preceding weeks to months and as a model of nonenzymatic, postsynthetic protein modification. 6 In this report we describe a relationship between one protein-bound carbohydrate, hexose, and glycemic control not previously established by other means and discuss the possible bearing this may have on the underlying mechanisms of protein-bound carbohydrate abnormality seen in diabetes.…”

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confidence: 99%

Serum Protein-bound Hexose in Diabetes: The Effect of Glycemic Control

1979

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To determine whether the carbohydrate content of serum proteins is related to overall glycemic control, we studied serum protein-bound hexose and glycosylated hemoglobin [HbA1(a+b+c)] in 37 ambulant diabetic patients and 32 nondiabetic controls. Protein-bound hexose was correlated with HbA1(a+b+c) in the diabetic patients (r = 0.36, P less than 0.025). The mean protein-bound hexose level of the diabetic patients was greater than that of the controls (190.8 versus 174.7 mg/dl, P less than 0.01), but diabetic patients with HbA1(a+b+c) less than 12% had a mean protein-bound hexose similar to the controls. In nine of the diabetic patients, mean protein-bound hexose and HbA1(a+b+c) were significantly reduced during a period of intensive outpatient care, while two major serum glycoproteins, haptoglobins and alpha-1-antitrypsin, were unchanged. Our findings support the hypothesis that increased glycosylation of serum proteins may occur in diabetes mellitus; this abnormality in serum protein-bound hexose may be corrected by close attention to overall glycemic control.

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Ver�nderungen der Serumeiwei?k�rper und der proteingebundenen Kohlenhydrate bei Diabetes mellitus

Cited by 34 publications

References 38 publications

Disturbance of Serum Viscosity in Diabetes Mellitus

Disturbance of Serum Viscosity in Diabetes Mellitus

Blood glycoprotein levels in diabetes mellitus

Serum Protein-bound Hexose in Diabetes: The Effect of Glycemic Control

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