Serum Protein-bound Hexose in Diabetes: The Effect of Glycemic Control

Kennedy, Allan Laurence; Kandell, Thomas W; Merimee, Thomas J.

doi:10.2337/diab.28.11.1006

Cited by 16 publications

(4 citation statements)

References 12 publications

(8 reference statements)

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“…Similarly, the significant correlation between FPG and GHb observed in this study is consistent with previous reports (1)(2)(3)(15)(16)(17). Although the absence of significant correlations between FPG, GP, and GA fractions appears surprising, our data are consistent with previous reports that showed significant relationships between FPG and GP fractions only in patients with diabetes mellitus and not in normal subjects (5,6). Finally, the lack of a significant relationship between age and GP and GA fractions observed in this study may concur with the belief that healthy elderly subjects may not manifest impaired glucose tolerance and hence may not demonstrate increased GP and GA concentrations.…”

Section: Discussionsupporting

confidence: 94%

Glycosylation of Proteins: Lack of Influence of Aging

Kabadi

1988

Diabetes Care

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In elderly nondiabetic individuals, increased glycosylation of hemoglobin has been reported. Most elderly subjects suffer from chronic disorders and consume one or more medications. Thus, it is conceivable that the increased glycosylation of hemoglobin may be secondary to factors other than old age. Furthermore, the data are sparse regarding the effect of aging on glycosylation of other proteins. In this study, glycosylated hemoglobin (GHb), glycosylated protein (GP), glycosylated albumin (GA), and fasting plasma glucose (FPG) concentrations were determined in 93 healthy nondiabetic subjects after an overnight fast. Strict criteria were observed to define the healthy status of these subjects to eliminate the influence of all other factors known to facilitate glycosylation of hemoglobin. No significant correlations were noted between age and FPG, GHb, GP, or GA (P greater than .05 for all correlations). Furthermore, no significant differences were observed between groups according to age for any of the parameters studied. Therefore, this study demonstrates that aging may not influence glycosylation of proteins in healthy subjects, and the previously observed increase in GHb concentrations in elderly populations may be related to associated factors rather than old age.

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Section: Discussionsupporting

confidence: 94%

Glycosylation of Proteins: Lack of Influence of Aging

Kabadi

1988

Diabetes Care

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“…Same has been reported by various workers including Gabbay et al (1976) 9 and Elkeles et al (1978). 10 Kennedy et al (1979) 11 found correlation between FBS and HbA 1 C levels were satisfactory while Nabarro et al (1979) 12 found correlation between HbA 1 C and FBS were not satisfactory. However, in some individual cases, there was no correlation between HbA 1 C and FBS.…”

Section: Discussionsupporting

confidence: 58%

Correlation between Fasting Blood Sugar Level, HbA1C Level and Serum Lipid Levels in Type 2 Diabetes Mellitus Patients

Dave¹,

Gupta²,

Patel³

et al. 2019

IJCMR

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Introduction: Diabetes Mellitus is one of the most common endocrinal diseases in the world. Incidences of this disease are increasing worldwide and this disease is called disease of this millennium. This study was undertaken to correlate fasting blood sugar level, Glycosylated haemoglobin (HbA 1 C) level and serum lipid levels in patients with diabetes mellitus. Material and Methods: This study was a cross sectional study conducted on 100 patients of diabetes mellitus came to M.B Govt. Hospital, Udaipur. The fasting blood sugar (FBS) levels, HbA 1 C levels and serum lipid levels were performed and then correlated fasting blood sugar level with HbA 1 C levels and FBS and HbA 1 C with serum lipid levels. There was a significant positive correlation between FBS and HbA 1 C, and FBS and HbA 1 C with serum cholesterol and serum triglycerides level and negative correlation with serum HDLcholesterol levels. Results: This study demonstrated that HbA 1 C level was increased in diabetics and it showed correlation with the status of control of diabetes. Conclusion: Diabetics have got increased level of serum cholesterol, triglycerides and decreased levels of serum HDL-cholesterol. HbA 1 C showed stronger correlation with serum cholesterol and triglycerides as compared to FBS. HDL-cholesterol showed stronger correlation with FBS than HbA 1 C.

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“…These classes of proteins could be modified post-translationally in diabetes so that they become larger, more acidic and/or carbohydrate-containing. For example, nonenzymic glycosylation of proteins from erythrocytes (Bunn et al, 1978;Miller et al, 1980) or serum (Kennedy et al, 1979;Day et al, 1980) occurs in proportion to the diabetic hyperglycaemia.…”

Section: Discussionmentioning

confidence: 99%

Selective depletion of small basic non-glycosylated proteins in diabetes

Samaniego¹,

Berry²,

Dice³

1981

Biochemical Journal

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Degradative rates of small basic non-glycosylated proteins are preferentially enhanced in rat liver cytosol during severe streptozotocin-induced diabetes. Synthetic rates of these classes of proteins are not selectively enhanced in diabetes, so small basic non-glycosylated proteins should be depleted from liver cytosol as a consequence of this disease. To test this hypothesis, proteins were analysed from normal animals, from diabetic animals receiving insulin and from diabetic animals after insulin withdrawal for 3 days. The proteins were separated according to subunit molecular weight by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis, according to isoelectric point by isoelectric focusing and according to carbohydrate content by affinity chromatography with concanavalin A linked to agarose. Severe uncontrolled diabetes is associated with the predicted depletion of small basic non-glycosylated proteins from liver cytosol. The preferential degradation and loss of these protein classes may be of considerable physiological importance to the animal.

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Serum Protein-bound Hexose in Diabetes: The Effect of Glycemic Control

Cited by 16 publications

References 12 publications

Glycosylation of Proteins: Lack of Influence of Aging

Glycosylation of Proteins: Lack of Influence of Aging

Correlation between Fasting Blood Sugar Level, HbA1C Level and Serum Lipid Levels in Type 2 Diabetes Mellitus Patients

Selective depletion of small basic non-glycosylated proteins in diabetes

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