Venous Vasomotion

Helden, Dirk F. van; Imtiaz, Mohammad

doi:10.1007/978-981-13-5895-1_13

Cited by 10 publications

(4 citation statements)

References 130 publications

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“…Furthermore, computational models have proposed LMC sarcoplasmic reticulum (SR) Ca 2+ release as the oscillator mechanism driving pacemaking (Imtiaz et al, 2007). SR Ca 2+ release has also been implicated in pericyte regulation of arterioles (Hashitani et al, 2015; van Helden and Imtiaz, 2019), in microvascular vasomotion (Boedtkjer et al, 2008; Aalkjaer et al, 2011; van Helden and Imtiaz, 2019), and in the contraction waves of atypical muscle cells of the lower urinary tract (Grainger et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions

Zawieja,

Pea,

Broyhill

et al. 2023

Preprint

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Collecting lymphatic vessels (cLVs) exhibit spontaneous contractions with a pressure-dependent frequency, but the identity of the lymphatic pacemaker cell is still debated. By analogy to pacemakers in the GI and lower urinary tracts, proposed cLV pacemaker cells include interstitial cells of Cajal like cells (ICLC), pericytes, as well as the lymphatic muscle (LMCs) cells themselves. Here we tested the extent to which these cell types are invested into the mouse cLV wall and if any cell type exhibited morphological and functional processes characteristic of pacemaker cells: a contiguous network; spontaneous Ca2+ transients; and depolarization-induced propagated contractions. We employed inducible Cre (iCre) mouse models routinely used to target these specific cell populations including: c-kitCreERT2 to target ICLC; PdgfrβCreERT2 to target pericytes; PdgfrαCreERTM to target CD34+ adventitial fibroblast-like cells or ICLC; and Myh11CreERT2 to target LMCs. These specific inducible Cre lines were crossed to the fluorescent reporter ROSA26mT/mG, the genetically encoded Ca2+ sensor GCaMP6f, and the light-activated cation channel rhodopsin2 (ChR2). c-KitCreERT2 labeled both a sparse population of LECs and round adventitial cells that responded to the mast cell activator compound 48-80. PdgfrβCreERT2 drove recombination in both adventitial cells and LMCs, limiting its power to discriminate a pericyte specific population. PdgfrαCreERTM labeled a large population of interconnected, oak leaf-shaped cells primarily along the adventitial surface of the vessel. Titrated induction of the smooth muscle-specific Myh11CreERT2 revealed a LMC population with heterogeneous morphology. Only LMCs consistently, but heterogeneously, displayed spontaneous Ca2+ events during the diastolic period of the contraction cycle, and whose frequency was modulated in a pressure-dependent manner. Optogenetic depolarization through the expression of ChR2 by Myh11CreERT2, but not PdgfrαCreERTM or c-KitCreERT2, resulted in a propagated contraction. These findings support the conclusion that LMCs, or a subset of LMCs, are responsible for mouse cLV pacemaking.

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Section: Introductionmentioning

confidence: 99%

Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions

Zawieja,

Pea,

Broyhill

et al. 2023

Preprint

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“…2011 ; Vermeij et al. 2014 ; van Helden and Imtiaz 2019 ). Vasomotion is a spontaneous oscillation that originates from the blood vessel wall with an infraslow oscillation (ISO) of 0.005–0.2 Hz ( Wiedeman 1957 ; Buerk and Riva 1998 ).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study

Shahdadian

Wang

Kang

et al. 2022

Cerebral Cortex Communications

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The resting-state infra-slow oscillation (ISO) of the cerebral cortex reflects the neurophysiological state of the human brain. ISO results from distinct vasomotion with endogenic (E), neurogenic (N), and myogenic (M) frequency bands. Quantification of prefrontal ISO in cortical haemodynamics and metabolism in the resting human brain may facilitate the identification of objective features characteristic of certain brain disorders. The goal of this study was to explore and quantify the prefrontal ISO of the cortical concentrations of oxygenated hemoglobin (Δ[HbO]) and redox-state cytochrome-c-oxidase (Δ[CCO]) as hemodynamic and metabolic activity metrics in all three E/N/M bands. Two-channel broadband near-infrared spectroscopy (2-bbNIRS) enabled measurements of the forehead of 26 healthy young participants in a resting state once a week for five weeks. After quantifying the ISO spectral amplitude (SA) and coherence at each E/N/M band, several key and statistically reliable metrics were obtained as key features: (1) SA of Δ[HbO] at all E/N/M bands, (2) SA of Δ[CCO] in the M band, (3) bilateral connectivity of hemodynamics and metabolism across the E and N bands, and (4) unilateral hemodynamic-metabolic coupling at both E and M bands. These features have promising potential to be developed as objective biomarkers for clinical applications in the future.

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“… 3 , 4 Previous studies have demonstrated the role of intrinsic rhythmic relaxation-contraction (i.e., vasomotion) of vascular walls in human cerebral metabolic and hemodynamic activity. 5 – 9 Vasomotion consists of spontaneous infra-slow oscillations (ISO) in the frequency range of 0.005 and 0.2 Hz, 10 , 11 which are related to different human brain functions. 12 In addition, disturbances in vasomotion have been associated with aging, neurological disorders, and other diseases such as atherosclerosis, 13 cardiovascular disease, 14 and Alzheimer’s disease.…”

Section: Introductionmentioning

confidence: 99%

Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults

et al. 2023

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Transcranial photobiomodulation (tPBM) is a noninvasive neuromodulation method that facilitates the improvement of human cognition. However, limited information is available in the literature on the wavelength-and site-specific effects of prefrontal tPBM. Moreover, 2-channel broadband near-infrared spectroscopy (2-bbNIRS) is a new approach for quantifying infra-slow oscillations (ISO; 0.005 to 0.2 Hz) of neurophysiological networks in the resting human brain in vivo.Aim: We aim to prove the hypothesis that the hemodynamic and metabolic activities of the resting prefrontal cortex are significantly modulated by tPBM and that the modulation is wavelength-and site-specific in different ISO bands.Approach: Noninvasive 8-min tPBM with an 800-or 850-nm laser or sham was delivered to either side of the forehead of 26 healthy young adults. A 2-bbNIRS unit was used to record prefrontal ISO activity 7 min before and after tPBM/sham. The measured time series were analyzed in the frequency domain to determine the coherence of hemodynamic and metabolic activities at each of the three ISO frequency bands. Sham-controlled coherence values represent tPBM-induced effects on neurophysiological networks.Results: Prefrontal tPBM by either wavelength and on either lateral side of the forehead (1) increased ipsilateral metabolic-hemodynamic coupling in the endogenic band and (2) desynchronized bilateral activity of metabolism in the neurogenic band and vascular smooth-muscle hemodynamics in the myogenic band. Site-specific effects of laser tPBM were also observed with significant enhancement of bilateral hemodynamic and metabolic connectivity by the right prefrontal 800-nm tPBM.Conclusions: Prefrontal tPBM can significantly modulate neurophysiological networks bilaterally and coupling unilaterally in the human prefrontal cortex. Such modulation effects are site-and wavelength-specific for each ISO band.

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Venous Vasomotion

Cited by 10 publications

References 130 publications

Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions

Characterization of the cellular components of mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells regulating lymphatic contractions

Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study

Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults

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