Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study

Shahdadian, Sadra; Wang, Xinlong; Kang, Shu; Carter, Caroline; Chaudhari, Akhil; Liu, Hanli

doi:10.1093/texcom/tgac033

Cited by 8 publications

(68 citation statements)

References 82 publications

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“…These metrics are (1) bilateral hemodynamic (i.e., Δ[HbO]) connectivity (bCONHbO), (2) bilateral metabolic (i.e., Δ[CCO]) connectivity (bCONCCO), (3) unilateral hemodynamic-metabolic coupling (uCOP) on the left, and (4) right side of the prefrontal cortex. In addition, we demonstrated that these constant and relatively reproducible metrics can be considered potential features of the human prefrontal cortex in young healthy adults 17 . We have also shown distinct alterations in these metrics across all three frequency bands in response to 1064-nm tPBM 16 …”

Section: Introductionmentioning

confidence: 74%

“…In addition, disturbances in vasomotion have been associated with aging, neurological disorders, and other diseases such as atherosclerosis, 13 cardiovascular disease, 14 and Alzheimer’s disease 15 . In other studies published by our group, we have shown that vasomotion and its frequency-domain characteristics over the prefrontal cortex at rest can be quantified as brain activity features in healthy humans 16 , 17 …”

Section: Introductionmentioning

confidence: 76%

“…As described in Ref. 17, 2-bbNIRS was implemented to measure NIR spectral changes on the bilateral foreheads of the participants under pre-tPBM/sham stimulation (resting-state) and post-tPBM/sham stimulations. Δ[HbO] and Δ[CCO] were quantified based on the absorption and scattering coefficients of the major chromophores in the tissue.…”

Section: Methodsmentioning

confidence: 99%

“…3). Similar to the previous approach, 17 four physiologically interpretable pairs of these signals were formed: bCONHbO, bCONCCO, and unilateral hemodynamic-metabolic coupling on the ipsilateral (uCOIpsi) or contralateral (uCOPContra) side to the tPBM/sham site. In Step 4, the abovementioned three steps were performed for both the pre- and post-stimulation periods separately, and the obtained coherence values were the baseline (or pre-stimulation) subtracted as the fourth step (purple box in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…Our group recently introduced a set of hemodynamic and metabolic characteristics quantified by frequency-domain connectivity analysis of hemodynamic and metabolic ISO activity in the prefrontal cortex, as assessed by dual-channel bbNIRS measurements 16 , 17 . These metrics are (1) bilateral hemodynamic (i.e., Δ[HbO]) connectivity (bCONHbO), (2) bilateral metabolic (i.e., Δ[CCO]) connectivity (bCONCCO), (3) unilateral hemodynamic-metabolic coupling (uCOP) on the left, and (4) right side of the prefrontal cortex.…”

Section: Introductionmentioning

confidence: 99%

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Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults

et al. 2023

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Transcranial photobiomodulation (tPBM) is a noninvasive neuromodulation method that facilitates the improvement of human cognition. However, limited information is available in the literature on the wavelength-and site-specific effects of prefrontal tPBM. Moreover, 2-channel broadband near-infrared spectroscopy (2-bbNIRS) is a new approach for quantifying infra-slow oscillations (ISO; 0.005 to 0.2 Hz) of neurophysiological networks in the resting human brain in vivo.Aim: We aim to prove the hypothesis that the hemodynamic and metabolic activities of the resting prefrontal cortex are significantly modulated by tPBM and that the modulation is wavelength-and site-specific in different ISO bands.Approach: Noninvasive 8-min tPBM with an 800-or 850-nm laser or sham was delivered to either side of the forehead of 26 healthy young adults. A 2-bbNIRS unit was used to record prefrontal ISO activity 7 min before and after tPBM/sham. The measured time series were analyzed in the frequency domain to determine the coherence of hemodynamic and metabolic activities at each of the three ISO frequency bands. Sham-controlled coherence values represent tPBM-induced effects on neurophysiological networks.Results: Prefrontal tPBM by either wavelength and on either lateral side of the forehead (1) increased ipsilateral metabolic-hemodynamic coupling in the endogenic band and (2) desynchronized bilateral activity of metabolism in the neurogenic band and vascular smooth-muscle hemodynamics in the myogenic band. Site-specific effects of laser tPBM were also observed with significant enhancement of bilateral hemodynamic and metabolic connectivity by the right prefrontal 800-nm tPBM.Conclusions: Prefrontal tPBM can significantly modulate neurophysiological networks bilaterally and coupling unilaterally in the human prefrontal cortex. Such modulation effects are site-and wavelength-specific for each ISO band.

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Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults

et al. 2023

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Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation

Shahdadian,

Wang,

Liu

2024

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Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005–0.02 Hz), neurogenic (N; 0.02–0.04 Hz), and myogenic (M; 0.04–0.2 Hz) frequency bands. In this study, we quantified changes in prefrontal concentrations of oxygenated hemoglobin (Δ[HbO]) and redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic and metabolic activity metrics, and electroencephalogram (EEG) powers as electrophysiological activity, using concurrent measurements of 2-channel broadband near-infrared spectroscopy and EEG on the forehead of 22 healthy participants at rest. After preprocessing, the multi-modality signals were analyzed using generalized partial directed coherence to construct unilateral neurophysiological networks among the three neurophysiological metrics (with simplified symbols of HbO, CCO, and EEG) in each E/N/M frequency band. The links in these networks represent neurovascular, neurometabolic, and metabolicvascular coupling (NVC, NMC, and MVC). The results illustrate that the demand for oxygen by neuronal activity and metabolism (EEG and CCO) drives the hemodynamic supply (HbO) in all E/N/M bands in the resting prefrontal cortex. Furthermore, to investigate the effect of transcranial photobiomodulation (tPBM), we performed a sham-controlled study by delivering an 800-nm laser beam to the left and right prefrontal cortex of the same participants. After performing the same data processing and statistical analysis, we obtained novel and important findings: tPBM delivered on either side of the prefrontal cortex triggered the alteration or reversal of directed network couplings among the three neurophysiological entities (i.e., HbO, CCO, and EEG frequency-specific powers) in the physiological network in the E and N bands, demonstrating that during the post-tPBM period, both metabolism and hemodynamic supply drive electrophysiological activity in directed network coupling of the prefrontal cortex (PFC). Overall, this study revealed that tPBM facilitates significant modulation of the directionality of neurophysiological networks in electrophysiological, metabolic, and hemodynamic activities.

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Neuromodulation of brain power topography and network topology by prefrontal transcranial photobiomodulation

et al. 2022

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Objective. Transcranial photobiomodulation (tPBM) has shown promising benefits, including cognitive improvement, in healthy humans and in patients with Alzheimer’s disease. In this study, we aimed to identify key cortical regions that present significant changes caused by tPBM in the electroencephalogram (EEG) oscillation powers and functional connectivity in the healthy human brain. Approach. A 64-channel EEG was recorded from 45 healthy participants during a 13-min period consisting of a 2-min baseline, 8-min tPBM/sham intervention, and 3-min recovery. After pre-processing and normalizing the EEG data at the five EEG rhythms, cluster-based permutation tests were performed for multiple comparisons of spectral power topographies, followed by graph-theory analysis (GTA) as a topological approach for quantification of brain connectivity metrics at global and nodal/cluster levels. Main results. EEG power enhancement was observed in clusters of channels over the frontoparietal regions in the alpha band and the centroparietal regions in the beta band. The global measures of the network revealed a reduction in synchronization, global efficiency, and small-worldness of beta band connectivity, implying an enhancement of brain network complexity. In addition, in the beta band, nodal graphical analysis demonstrated significant increases in local information integration and centrality over the frontal clusters, accompanied by a decrease in segregation over the bilateral frontal, left parietal, and left occipital regions. Significance. Frontal tPBM increased EEG alpha and beta powers in the frontal-central-parietal regions, enhanced the complexity of the global beta-wave brain network, and augmented local information flow and integration of beta oscillations across prefrontal cortical regions. This study sheds light on the potential link between electrophysiological effects and human cognitive improvement induced by tPBM.

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Prefrontal cortical connectivity and coupling of infraslow oscillation in the resting human brain: a 2-channel broadband NIRS study

Cited by 8 publications

References 82 publications

Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults

Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults

Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation

Neuromodulation of brain power topography and network topology by prefrontal transcranial photobiomodulation

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