Venous ulcer: epidemiology, physiopathology, diagnosis and treatment

Abbade, Luciana Patrícia Fernandes; Lastória, Sidnei

doi:10.1111/j.1365-4632.2004.02456.x

Cited by 285 publications

(237 citation statements)

References 55 publications

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“…This is the result of vein blockage, incompetency or in some cases both. They are more common in the elderly and female population [4]. To date, various hypothesis have been suggested about the process of ulceration.…”

Section: Discussionmentioning

confidence: 99%

Intermittent Pneumatic Compression in Treatment of Chronic Venous Leg Ulcers: A Case Report and Review of Literature

Kordzadeh¹,

Jonas²,

Panayiotopoulos³

2014

CRCM

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Introduction: The benefit of intermittent pneumatic compression (IPC) for the prevention of venous thromboembolism and lymphedema has been well established in the literature. Recent evidence suggests that IPC plays a beneficial role in circulation, hemodynamic peripheral pump, intravascular coagulation and arterial skin perfusion. Despite such evidence, the use of IPC in the treatment of resistant and chronic venous leg ulcers, has received little attention in practice. Case Presentation: We would like to report the case of successfully treated chronic and bilateral venous leg ulcer in an obese patient with IPC application and a review of the literature. Results: The use of IPC as an adjuvant therapy to the traditional multilayered compression therapy permitted significant resolution of the ulcers, reduced secondary infection incidence and prevented ulcer recurrence. Conclusion: In obese, minimally mobile patients with venous ulcers not responding to the traditional multilayered compression therapy application of IPC, an adjuvant therapy is recommended.

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Section: Discussionmentioning

confidence: 99%

Intermittent Pneumatic Compression in Treatment of Chronic Venous Leg Ulcers: A Case Report and Review of Literature

Kordzadeh¹,

Jonas²,

Panayiotopoulos³

2014

CRCM

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“…According to many authors, the lysis of grafts at autodermoplasty on ready-to-plastic granulation is most often associ-ated with the microbial colonization of wounds [1,3,14,15]. Therefore, the current selection is not only a means effective against pathogenic microorganisms, but also a method of treating postoperative wounds after autodermoplasty.…”

Section: Discussionmentioning

confidence: 99%

“…The low efciency of antibacterial agents, multiple adverse reactions dictate the need of searching for new highly effective remedies. So, researchers often pay attention to herbal substances as sources for biologically active compounds which have a modifying activity against the pathogenic and persistent potential of microbes [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Antimikrobinės atsparumas. Naujos antimikrobinės medžiagos lėtinėms trofinėms opoms gydyti

Frolova¹,

Косинец²

2015

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Background / objectiveThe steady growing number of pathogenic microorganisms resistant not only to antibiotics but also to antiseptics complicates the cure of the wound process. The sensibilization of skin to the majority of locally applicable preparations creates certain difficulties in the treatment of chronic trophic ulcers. The new herbal remedy PhytoMP was developed based on two components (Macleaya microcarpa (Maxim.) Fedde, Papaveraceae family and Plantago major L., Plantaginaceae family). A new atraumatic combined dressing was developed based on polyester curtain nets coated with copper particles 0.2 mcm in size and a linen nonwoven sorbent containing silver nanoparticles stabilized by PhytoMP. The aim of the present study was to investigate the possibility of these developments to improve the effectiveness of the complex therapy of trophic ulcers of the lower limbs. Methods A clinical trial study was conducted in the Republic Center of Surgical Infection, Belarus. Patients (n = 42) with chronic trophic ulcers of the lower limbs participated in the study. The sensitivity of microorganisms to antibiotics, herbal remedy, and metallic fabrics was determined by the method to diffusions in agar. By the method of the dose-and time-dependent killing of pathogens, the minimal inhibitory concentration for PhytoMP and the duration of its antimicrobial effect was evaluated. The total treatment response was evaluated on the basis of changes in the clinical manifestations of the disease, according to the subjective feelings of patients, the degree of bacterial contamination, the terms of the appearance of granulation, epithelialization, healing, and the cytological picture. The parameters were evaluated before the treatment and every third day in the period until complete ulcer healing. The data were analyzed statistically. Results Bacteriological examination revealed that the microflora of trophic ulcers in 37.04% of cases was introduced by S. aureus which was resistant to the majority of antibiotics. A comparative analysis demonstrated the significant differences in terms of a complete cleansing of ulcers from pathogens: with use of PhytoMP on the 7.38 ± 0.65 day, while in the control group it was on 8.30 ± 0.48 day (p < 0.01). The average hospital stay of patients with trophic ulcers from the main group was 30.77 ± 2.01 bed-days and from the control group 35.50 ± 1.72 bed-days (p < 0.01). It was experimentally established that the use of PhytoMP infusion as a matrix for stabilizing silver nanoparticles allows to halve the amount of the metal in a linen nonwoven 32 A . F r o l o v a , A . K o s i n e t s sorbent, and to achieve a strong antimicrobial effect against S. aureus and E. coli. It was noted that, due to the strong antimicrobial effect, the physical properties of the developed combined dressings, their high anti-adhesive activity allowing carrying out the atraumatic change of bandage without moving a flap, successful results of skin plastic were observed. Conclusions This study suggests that the developed ...

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“…1 Sua etiologia, multifatorial, está associada à doença venosa crônica, doença arterial periférica, neuropatia, hipertensão arterial, trauma físico, infecções cutâneas e neoplasias. Indivíduos com diabetes mellitus, quando portadores de úlceras cutâneas nos membros inferiores -principalmente nos pés -ficam mais propensos à amputação do membro afetado, com consequente invalidez e piora da qualidade de vida.…”

Section: Introductionunclassified

Úlcera crônica tratada com gel de papaína 10% na Estratégia Saúde da Família: relato de experiência

Souza

Franco

Oliveira

et al. 2017

Rev Bras Med Fam Comunidade

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a Chronic ulcer treated with 10% papain gel by Family Health Strategy: experience reportAs úlceras em membros inferiores são um problema de saúde pública em razão da significativa incidência, do elevado custo e de frequente recidiva. Frequentemente, a equipe da Estratégia Saúde da Família é o primeiro contato do portador de úlcera, necessitando estar atualizada acerca das opções terapêuticas. Um produto tópico utilizado no tratamento das úlceras cutâneas é o gel de papaína a 10%, devido às suas propriedades bactericida, bacteriostática e desbridante de tecidos necrosados, bem como acelerador de crescimento tecidual. Descreve-se a experiência da equipe da Estratégia Saúde da Família com a utilização de gel de papaína a 10% no tratamento de úlcera cutânea, que regrediu após o uso do gel, destacando-se o matriciamento pelo especialista para a resolutividade do caso. (39)1355 www.rbmfc.org.br CASOS CLÍNICOS Ulcera crónica tratada con papaína gel al 10% en Estrategia Salud de la Familia: informe de experienciaLower body ulcers are a public health problem due to the significant incidence, high cost and frequent recurrence. Often, the Family Strategy Unit team provides first contact care with the ulcer carrier, so is a requirement for the team to be updated about treatment options. A topical product used for treatment of cutaneous ulcers is 10% papain gel, due to its antibacterial and debridant characteristics of necrotic tissues and the promotion of tissue renovation. This report describes the experience of Family Strategy Unit team using 10% papain gel in the treatment of cutaneous ulcers, which regressed after thirty days of this use, with emphasis on the support by the specialist for the resolution of the case. Las úlceras en las piernas son un problema de salud pública debido a las repercusiones significativas del alto costo y la recurrencia frecuente. A menudo, el personal de la Estrategia Salud de la Familia es el contacto inicial. El equipo necesita saber sobre los nuevos tratamientos. El producto tópico utilizado en el tratamiento de úlceras de la piel es el gel de papaína 10% debido a sus propiedades bactericidas, bacteriostáticos y desbridamiento de tejido necrótico y acelerador de crecimiento del tejido. Se describe la experiencia del equipo de Salud de la Familia con el utilización de gel de papaína 10% en el tratamiento de úlceras de la piel, que se resolvió después de usar el gel, la matriz destacando el experto para la resolución del caso.

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Venous ulcer: epidemiology, physiopathology, diagnosis and treatment

Cited by 285 publications

References 55 publications

Intermittent Pneumatic Compression in Treatment of Chronic Venous Leg Ulcers: A Case Report and Review of Literature

Intermittent Pneumatic Compression in Treatment of Chronic Venous Leg Ulcers: A Case Report and Review of Literature

Antimikrobinės atsparumas. Naujos antimikrobinės medžiagos lėtinėms trofinėms opoms gydyti

Úlcera crônica tratada com gel de papaína 10% na Estratégia Saúde da Família: relato de experiência

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