Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma

Matsuo, Koji; Hasegawa, Kosei; Yoshino, Kiyoshi; Murakami, Ryusuke; Hisamatsu, Takeshi; Stone, Rebecca L.; Previs, Rebecca A.; Hansen, Jean M.; Ikeda, Yuji; Miyara, Akiko; Hiramatsu, Kosuke; Enomoto, Takayuki; Fujiwara, Keiichi; Matsumura, Noriomi; Konishi, Ikuo; Roman, Lynda D.; Gabra, Hani; Fotopoulou, Christina; Sood, Anil K.

doi:10.1016/j.ejca.2015.07.012

Cited by 51 publications

(41 citation statements)

References 38 publications

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“…Procoagulant microparticles were found along with venous thromboemboli in cancer patients [258,259]. The impact of IL6 on thrombocytosis has been observed elsewhere and in other cancers [260,261]. …”

Section: Thrombocytosismentioning

confidence: 99%

Platelet “first responders” in wound response, cancer, and metastasis

Menter

Kopetz

Hawk

et al. 2017

Cancer Metastasis Rev

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145

115

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Platelets serve as “First Responders” during normal wounding and homeostasis. Arising from bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence inflammation and immune regulation. Biophysically, platelets are optimized due to size and discoid morphology to distribute near vessel walls, monitor vascular integrity and initiate quick responses to vascular lesions. Adhesion receptors linked to a highly reactive filopodia-generating cytoskeleton maximizes their vascular surface contact allowing rapid response capabilities. Functionally, platelets normally initiate rapid clotting, vasoconstriction, inflammation and wound biology that leads to sterilization, tissue repair and resolution. Platelets also are among the first to sense, phagocytize, decorate, or react to pathogens in the circulation. These platelet first responder properties are commandeered during chronic inflammation, cancer progression and metastasis. Leaky or inflammatory reaction blood vessel genesis during carcinogenesis provides opportunities for platelet invasion into tumors. Cancer is thought of as a non-healing or chronic wound that can be actively aided by platelet mitogenic properties to stimulate tumor growth. This growth ultimately outstrips circulatory support leads to angiogenesis and intravasation of tumor cells into the blood stream. Circulating tumor cells reengage additional platelets, which facilitates tumor cell adhesion, arrest and extravasation and metastasis. This process, along with the hypercoagulable states associated with malignancy is amplified by IL6 production in tumors that stimulate liver thrombopoietin production and elevates circulating platelet numbers by thrombopoiesis in the bone marrow. These complex interactions and the “First Responder” role of platelets during diverse physiologic stresses provides a useful therapeutic target that deserves further exploration.

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Section: Thrombocytosismentioning

confidence: 99%

Platelet “first responders” in wound response, cancer, and metastasis

Menter

Kopetz

Hawk

et al. 2017

Cancer Metastasis Rev

Self Cite

145

115

View full text Add to dashboard Cite

show abstract

“…Patients who developed VTE are likely to have an advanced-stage disease or recurrent progressive tumors. 14,38 Current study and others have demonstrated that survival time after VTE are generally poor among patients diagnosed with VTE. 14 This was practically true after recurrence.…”

Section: Discussionmentioning

confidence: 98%

Signs and Symptoms of Venous Thromboembolism and Survival Outcome of Endometrial Cancer

Machida

Hom

Maeda³

et al. 2016

Int J Gynecol Cancer

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“…This state is marked by increased IL-6 cytokine expression as manifested in patients with type 2 diabetes and hypertension [9,10]. Low dose of omega 3 fish oil used by HIV positive clients have not shown any benefits in reduction of IL-6 expression [11]. Elevated IL-6 expression in chronic conditions is associated with poor progression and clinical outcomes of patients [12,13].…”

Section: Introductionmentioning

confidence: 99%

Cytokine Expression and Hypertension Comorbidity in HIV/AIDS Patients at Kenyatta National Hospital HIV Care Centre, Nairobi, Kenya

Chepchirchir¹,

Nyagol²,

Jaoko³

2018

Int J Cardiovasc Res

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Chronic inflammation in HIV disease is sustained by immune reconstitution that results from use of combination therapy by patients and manifested by increased expression of inflammatory cytokines. Chronic inflammation in HIV disease is associated with endothelial dysfunction of the cardio vasculature giving rise to reduced elasticity resulting in high blood pressure. This state is marked by increased IL-6 cytokine expression as manifested in patients with type 2 diabetes and hypertension. This study sought to establish cytokine expression in HIV seropositive patients with hypertension comorbidity and correlate with HIV/AIDS progression. We hypothesized that chronic inflammation and presence of hypertension comorbidity presents higher levels of expression of selected interleukins namely IL-6, IL-8 and IL-17A. This study demonstrated that the IL-6 cytokine expression have a positive correlation with the release of IL-8 cytokine as patients with higher IL-6 cytokine values were more likely to have higher IL-8 cytokine levels. This shows that a synergistic effect from both cytokines may accelerate the development of atherosclerosis on blood vessels. Therefore routine measurement of these cytokines may increase prediction of risk of development of hypertension in patients on HIV care.

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Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma

Abstract: (243 words)Background: We compared survival outcomes and risk of venous thromboembolism

Cited by 51 publications

References 38 publications

Platelet “first responders” in wound response, cancer, and metastasis

Platelet “first responders” in wound response, cancer, and metastasis

Signs and Symptoms of Venous Thromboembolism and Survival Outcome of Endometrial Cancer

Cytokine Expression and Hypertension Comorbidity in HIV/AIDS Patients at Kenyatta National Hospital HIV Care Centre, Nairobi, Kenya

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