Venous thromboembolism in the trauma patient

Tai, Stephen; Buddhdev, Pranai; Baskaradas, Aroon; Sivarasan, Nishanth; Tai, Nigel

doi:10.1016/j.mporth.2013.08.013

Cited by 5 publications

(2 citation statements)

References 62 publications

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“…Современные клинические рекомендации по профилактике ВТЭО позволяют уменьшить количество флеботромбозов и ТЭЛА у хирургических пациентов с высоким риском их развития на 40-60 %. Однако все существующие в настоящее время протоколы профилактики венозных тромбоэмболических осложнений признаются недостаточно эффективными при наличии трёх и более факторов риска развития ВТЭО у пациентов с хирургической патологией [27].…”

Section: материалы и методыunclassified

A modern approach to the study of the problem of pathogenesis and prevention venous thromboembolic complications in patients with trauma (literature review)

Lega,

Stolyarov,

Supilnikov

2024

vmirvz

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Relevance. Patients with trauma are at increased risk of venous thromboembolic complications (VTE), which includes deep vein thrombosis of the lower extremities (DVT) and pulmonary embolism (PE). Within surgical and trauma clinics, thromboembolic complications are the most common preventable cause of in-hospital mortality. Numerous studies have shown that the incidence rate of deep vein thrombosis (DVT) in trauma patients without prevention varies from 5 to 80%.Aim. To analyze the pathogenesis of the development of venous thrombosis and explore existing approaches to prevent VTE in trauma patients.Materials and methods. In the course of the work, topical literary sources of domestic and foreign authors on a given topic were analyzed.Results. The mechanism of thrombus formation in trauma involves slowing blood flow, damage to the vessel wall and impaired blood clotting in the form of hypercoagulation. The state of hypercoagulation combined with prolonged immobility increases the risk of VTE. LMWH is the treatment of choice for the prevention of VTE in trauma. Today, there are ongoing studies related to the correction of preventive doses of LMWH and the search for a single standard, depending on numerous factors.Conclusion. Severity and multiplicity of lesions correlate with severity of systemic inflammation, hypercoagulation, and incidence of venous thrombosis. However, this correlation has not been sufficiently studied in the scientific literature. The search for specific methods for the prevention of deep vein thrombosis leading to PE is an urgent problem of surgery of injuries both peaceful and wartime.

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Section: материалы и методыunclassified

A modern approach to the study of the problem of pathogenesis and prevention venous thromboembolic complications in patients with trauma (literature review)

Lega,

Stolyarov,

Supilnikov

2024

vmirvz

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“…Base deficit represents one of the most important parameters in monitoring patients with multiple trauma and hemorrhagic shock. Base excess (BE) less than - 6 mmol/L indicates a possible intra-abdominal disease with massive blood loss or acute pulmonary failure [ 27 ]. Moreover there is a strong relationship between mortality and base excess in patients with multiple trauma and blood loss more than 50 % [ 28 ].…”

Section: Reviewmentioning

confidence: 99%

New perspectives of volemic resuscitation in polytrauma patients: a review

et al. 2016

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Nowadays, fluid resuscitation of multiple trauma patients is still a challenging therapy. Existing therapies for volume replacement in severe haemorrhagic shock can lead to adverse reactions that may be fatal for the patient. Patients presenting with multiple trauma often develop hemorrhagic shock, which triggers a series of metabolic, physiological and cellular dysfunction. These disorders combined, lead to complications that significantly decrease survival rate in this subset of patients. Volume and electrolyte resuscitation is challenging due to many factors that overlap. Poor management can lead to post-resuscitation systemic inflammation causing multiple organ failure and ultimately death. In literature, there is no exact formula for this purpose, and opinions are divided. This paper presents a review of modern techniques and current studies regarding the management of fluid resuscitation in trauma patients with hemorrhagic shock. According to the literature and from clinical experience, all aspects regarding post-resuscitation period need to be considered. Also, for every case in particular, emergency therapy management needs to be rigorously respected considering all physiological, biochemical and biological parameters.

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