Venous thromboembolism in cancer patients: Still looking for answers (Review)

Iorga, Roua Anamaria; Bratu, Ovidiu Gabriel; Marcu, Radu Dragos; Constantin, Traian; Mischianu, Dan; Socea, Bogdan; Găman, Mihnea‐Alexandru; Diaconu, Camelia Cristina

doi:10.3892/etm.2019.8019

Cited by 28 publications

(33 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cases with early cervical cancer treated primary by surgical approach should continue with adjuvant therapy in the presence of findings that suggests an increased risk of recurrence. The benefit of surgery compared with radiotherapy is the possibility of ovarian conservation through surgery avoiding premature menopause and offering possibilities for reproduction technologies (42).…”

Section: Discussionmentioning

confidence: 99%

Impact of histological subtype on the response to chemoradiation in locally advanced cervical cancer and the possible role of surgery

et al. 2020

View full text Add to dashboard Cite

Cervical cancer is one of the most common cancers in women in developing countries, second only to breast cancer, with more than 450.000 new cases every year. Romania has the highest incidence of cervical cancer in Europe; more than four times the incidence found in Western Europe. Radiotherapy with or without chemotherapy is considered in most countries the gold standard for locally advanced cervical cancer. In Romania, if downstaging occurs after radiotherapy, adjuvant surgery is routinely performed. Thus, in the present study, we investigated the rate of residual cancer in patients with locally advanced cervical cancer who underwent surgery after concurrent chemoradiotherapy and to determine the impact of tumor histological subtype on the chemoradiotherapy response. Of a total of 461 patients with locally advanced cervical cancer that underwent chemoradiotherapy and adjuvant surgery, 254 had a partial response defined as the presence of residual tumor at pathology examination. Depending on the histological subtype of the cervical cancer, partial response was obtained in 50.6% of squamous cell carcinoma cases and in 77.6% of adenocarcinoma or adenosquamous carcinoma cases. The present study demonstrated that cervical cancer patients with adenocarcinomas and adenosquamous carcinomas had a significantly poorer treatment response to chemoradiotherapy than those with squamous cell carcinomas. We consider that in such cases where residual tumor is present, adjuvant surgery is mandatory for improving the survival rates.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of histological subtype on the response to chemoradiation in locally advanced cervical cancer and the possible role of surgery

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, systemic metastasis is not a contraindication to reconstruct the breast. A proper therapeutic management must be done [17,18]. In our clinic, we had one patient with stage IV breast cancer, with bone metastasis, who had chemoradiotherapy prior to the reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Timing between Breast Reconstruction and Oncologic Mastectomy—One Center Experience

et al. 2020

View full text Add to dashboard Cite

Background and objectives: Breast cancer is the most common cancer in women. The immunohistochemical profile, but also the stage of the tumor determines the therapeutic management, which varies from conservative surgery to mastectomy associated with chemotherapy, hormonal and biological therapy and/or radiotherapy. Mastectomy remains one of the most radical surgical intervention for women, having great consequences on quality of life, which can be improved by realizing immediate or delayed breast reconstruction. The objective of the study was to evaluate the period of time between the mastectomy and the breast reconstruction. Material and methods: We performed a retrospective study on 57 female patients admitted to the Plastic Surgery Department of the Clinical Emergency Hospital “Prof. Dr. Agrippa Ionescu”, Bucharest, Romania. All the patients underwent immediate or delayed breast reconstruction after mastectomy for confirmed breast cancer. Descriptive data analysis was realized with evaluation of type of breast reconstruction considering the staging of the tumor, the invaded lymph nodes, and the necessity of adjuvant chemoradiotherapy. Moreover, the median period between mastectomy and reconstruction was evaluated. Results: The immediate breast reconstruction was performed in patients with stage I, in patients with stage II, delayed reconstruction was performed after minimum six months, and the patients with stage III had the breast reconstructed with free flap (50%), 8–43 months post-mastectomy. Radiotherapy determines the type of breast reconstruction, in most of the cases the latissimus dorsi flap was used with implant (22.6%). Conclusions: Breast reconstruction is an important step in increasing the quality of life for women who underwent mastectomy after breast cancer. The proper timing for breast reconstruction must be settled by a team formed by the patient, the plastic surgeon, and the oncologist.

show abstract

“…Recently, Găman et al, [ 32 ] also found that oxidative stress levels were higher and thrombotic events were more frequent in ET patients who had an old age at diagnosis, higher haematocrit levels or leukocytosis. Further, Iorga et al, [ 33 ] reported that patients with cancer have a greater risk of both venous thromboembolism (VTE) and bleeding. A Danish retrospective study showed that patients that had VTE 1 year before the cancer diagnosis had a slightly increased risk of distant metastasis at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%